Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HSD11B1
  • Mouse genes Hsd11b1
  • Rat genes Hsd11b1
  • Zfish genes hsd11b1la,hsd11b1lb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hsd11b1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	HSD11B1	IDA		Human	PMID:10497248
Molecular Function	GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	HSD11B1	IDA		Human	PMID:15152005
Molecular Function	GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	HSD11B1	IDA		Human	PMID:17070044
Molecular Function	GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	HSD11B1	IDA		Human	PMID:17919905
Molecular Function	GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	Hsd11b1	IDA		Mouse	PMID:8940387
Molecular Function	GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	Hsd11b1	IMP	MGI:MGI:2385796	Mouse	PMID:12439781
Molecular Function	GO:0050661	NADP binding	HSD11B1	IDA		Human	PMID:15513927
Molecular Function	GO:0050661	NADP binding	HSD11B1	IDA		Human	PMID:17919905
Molecular Function	GO:0050661	NADP binding	HSD11B1	IDA		Human	PMID:18069989
Molecular Function	GO:0050661	NADP binding	HSD11B1	IDA		Human	PMID:18485702
Molecular Function	GO:0050661	NADP binding	HSD11B1	IDA		Human	PMID:18553955
Molecular Function	GO:0050661	NADP binding	HSD11B1	IDA		Human	PMID:19217779
Molecular Function	GO:0050661	NADP binding	Hsd11b1	IDA		Rat	PMID:15761036|RGD:1625105
Molecular Function	GO:0042803	protein homodimerization activity	HSD11B1	IDA		Human	PMID:15513927
Molecular Function	GO:0042803	protein homodimerization activity	HSD11B1	IDA		Human	PMID:17919905
Molecular Function	GO:0042803	protein homodimerization activity	HSD11B1	IDA		Human	PMID:18069989
Molecular Function	GO:0042803	protein homodimerization activity	HSD11B1	IDA		Human	PMID:18485702
Molecular Function	GO:0042803	protein homodimerization activity	HSD11B1	IDA		Human	PMID:18553955
Molecular Function	GO:0042803	protein homodimerization activity	HSD11B1	IDA		Human	PMID:19217779
Molecular Function	GO:0005496	steroid binding	Hsd11b1	IPI	CHEBI:16827	Rat	PMID:15761036|RGD:1625105
Cellular Component	GO:0045177	apical part of cell	Hsd11b1	IDA		Rat	PMID:12810566|RGD:1625059
Cellular Component	GO:0005737	cytoplasm	Hsd11b1	IDA		Rat	PMID:12810566|RGD:1625059
Cellular Component	GO:0005789	endoplasmic reticulum membrane	HSD11B1	IDA		Human	PMID:10497248
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Hsd11b1	IDA		Rat	PMID:16234247|RGD:1625062
Cellular Component	GO:0016020	membrane	HSD11B1	HDA		Human	PMID:19946888
Cellular Component	GO:0031965	nuclear membrane	Hsd11b1	IDA		Rat	PMID:11250946|RGD:1625110
Cellular Component	GO:0005791	rough endoplasmic reticulum	Hsd11b1	IDA		Rat	PMID:11250946|RGD:1625110
Biological Process	GO:0071392	cellular response to estradiol stimulus	Hsd11b1	IEP		Rat	PMID:19380458|RGD:4891036
Biological Process	GO:0006704	glucocorticoid biosynthetic process	Hsd11b1	IDA		Rat	PMID:12460758|RGD:1625060
Biological Process	GO:0006713	glucocorticoid catabolic process	Hsd11b1	IDA		Rat	PMID:12460758|RGD:1625060
Biological Process	GO:0030324	lung development	Hsd11b1	IMP	MGI:MGI:2385796	Mouse	PMID:12439781
Biological Process	GO:0008212	mineralocorticoid metabolic process	Hsd11b1	IDA		Rat	PMID:2808402|RGD:728825
Biological Process	GO:0043456	regulation of pentose-phosphate shunt	Hsd11b1	IDA		Rat	PMID:16234247|RGD:1625062
Biological Process	GO:0031667	response to nutrient levels	Hsd11b1	IEP		Rat	PMID:16941667|RGD:4891037

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern