Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HSD11B2
  • Mouse genes Hsd11b2
  • Rat genes Hsd11b2
  • Zfish genes hsd11b2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hsd11b2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070523	11-beta-hydroxysteroid dehydrogenase (NAD+) activity	HSD11B2	IMP		Human	PMID:8538347
Molecular Function	GO:0070523	11-beta-hydroxysteroid dehydrogenase (NAD+) activity	hsd11b2	IDA		Zfish	PMID:33387577
Molecular Function	GO:0051287	NAD binding	Hsd11b2	IDA		Rat	PMID:15761036|RGD:1625105
Molecular Function	GO:0005496	steroid binding	Hsd11b2	IPI	CHEBI:16827	Rat	PMID:15761036|RGD:1625105
Cellular Component	GO:0005737	cytoplasm	Hsd11b2	IDA		Rat	PMID:15761036|RGD:1625105
Cellular Component	GO:0005737	cytoplasm	Hsd11b2	IDA		Rat	PMID:18620340|RGD:152025256
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	HSD11B2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Hsd11b2	IDA		Rat	PMID:15761036|RGD:1625105
Biological Process	GO:0034650	cortisol metabolic process	HSD11B2	IMP		Human	PMID:8538347
Biological Process	GO:0034650	cortisol metabolic process	hsd11b2	IDA		Zfish	PMID:23042946
Biological Process	GO:0007565	female pregnancy	Hsd11b2	IMP		Mouse	PMID:23677469
Biological Process	GO:0007565	female pregnancy	Hsd11b2	IEP		Rat	PMID:19050325|RGD:2308933
Biological Process	GO:0008211	glucocorticoid metabolic process	Hsd11b2	IDA		Rat	PMID:11755176|RGD:727334
Biological Process	GO:0008211	glucocorticoid metabolic process	Hsd11b2	IDA		Rat	PMID:16763064|RGD:1625084
Biological Process	GO:0033555	multicellular organismal response to stress	hsd11b2	IDA		Zfish	PMID:23349977
Biological Process	GO:0002017	regulation of blood volume by renal aldosterone	Hsd11b2	IMP		Rat	PMID:15718388|RGD:1625109
Biological Process	GO:0032094	response to food	Hsd11b2	IEP		Rat	PMID:18548384|RGD:2308938
Biological Process	GO:0051384	response to glucocorticoid	Hsd11b2	IEP		Rat	PMID:19490994|RGD:2308927
Biological Process	GO:0001666	response to hypoxia	Hsd11b2	IEP		Rat	PMID:19470702|RGD:2308928
Biological Process	GO:0032868	response to insulin	Hsd11b2	IEP		Rat	PMID:9495277|RGD:2308926
Biological Process	GO:0048545	response to steroid hormone	Hsd11b2	IEP		Rat	PMID:18032797|RGD:2308921
Biological Process	GO:0009410	response to xenobiotic stimulus	Hsd11b2	IEP		Rat	PMID:10792625|RGD:2308925

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern