Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HSD17B10
  • Mouse genes Hsd17b10
  • Rat genes Hsd17b10
  • Zfish genes hsd17b10
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hsd17b10

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	HSD17B10	IDA		Human	PMID:12917011
Molecular Function	GO:0047015	3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity	HSD17B10	IDA		Human	PMID:18996107
Molecular Function	GO:0047015	3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity	HSD17B10	IDA		Human	PMID:19706438
Molecular Function	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	HSD17B10	IDA		Human	PMID:12917011
Molecular Function	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	HSD17B10	IDA		Human	PMID:23042678
Molecular Function	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	HSD17B10	IDA		Human	PMID:25925575
Molecular Function	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	HSD17B10	IDA		Human	PMID:28888424
Molecular Function	GO:0018454	acetoacetyl-CoA reductase activity	Hsd17b10	IDA		Rat	PMID:11023795|RGD:2302237
Molecular Function	GO:0001540	amyloid-beta binding	Hsd17b10	IDA		Rat	PMID:11023795|RGD:2302237
Molecular Function	GO:0106281	chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity	HSD17B10	IDA		Human	PMID:12917011
Molecular Function	GO:0008709	cholate 7-alpha-dehydrogenase activity	HSD17B10	IDA		Human	PMID:12917011
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	Hsd17b10	IDA		Rat	PMID:11023795|RGD:2302237
Molecular Function	GO:0042802	identical protein binding	Hsd17b10	IPI	RGD:69231	Rat	PMID:11023795|RGD:2302237
Molecular Function	GO:0106282	isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity	HSD17B10	IDA		Human	PMID:12917011
Molecular Function	GO:0051287	NAD binding	Hsd17b10	IDA		Rat	PMID:11023795|RGD:2302237
Molecular Function	GO:0030331	nuclear estrogen receptor binding	Hsd17b10	IPI	RGD:2581	Rat	PMID:19422801|RGD:4890964
Molecular Function	GO:0005515	protein binding	HSD17B10	IPI	UniProtKB:Q7L0Y3	Human	PMID:18984158
Molecular Function	GO:0005515	protein binding	HSD17B10	IPI	UniProtKB:Q7L0Y3	Human	PMID:23042678
Molecular Function	GO:0005515	protein binding	HSD17B10	IPI	UniProtKB:Q7L0Y3	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	HSD17B10	IPI	UniProtKB:Q7L0Y3	Human	PMID:29040705
Molecular Function	GO:0005515	protein binding	HSD17B10	IPI	UniProtKB:P13639	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	HSD17B10	IPI	UniProtKB:Q12931	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	HSD17B10	IPI	UniProtKB:Q7L0Y3	Human	PMID:29880640
Molecular Function	GO:0005515	protein binding	HSD17B10	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSD17B10	IPI	UniProtKB:P05067:PRO_0000000092	Human	PMID:32825572
Molecular Function	GO:0005515	protein binding	HSD17B10	IPI	UniProtKB:P05067	Human	PMID:9338779
Molecular Function	GO:0003723	RNA binding	HSD17B10	HDA		Human	PMID:22681889
Molecular Function	GO:0005496	steroid binding	Hsd17b10	IDA		Rat	PMID:11023795|RGD:2302237
Molecular Function	GO:0047035	testosterone dehydrogenase (NAD+) activity	HSD17B10	IDA		Human	PMID:12917011
Molecular Function	GO:0030283	testosterone dehydrogenase [NAD(P)] activity	HSD17B10	IDA		Human	PMID:28888424
Molecular Function	GO:0000049	tRNA binding	HSD17B10	IDA		Human	PMID:29040705
Molecular Function	GO:0106283	ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity	HSD17B10	IDA		Human	PMID:12917011
Cellular Component	GO:0005783	endoplasmic reticulum	Hsd17b10	IDA		Mouse	PMID:15962010
Cellular Component	GO:0005743	mitochondrial inner membrane	Hsd17b10	HDA		Mouse	PMID:12865426
Cellular Component	GO:0042645	mitochondrial nucleoid	HSD17B10	IDA		Human	PMID:24703694
Cellular Component	GO:0042645	mitochondrial nucleoid	Hsd17b10	IDA		Mouse	PMID:24703694
Cellular Component	GO:0030678	mitochondrial ribonuclease P complex	HSD17B10	IPI		Human	PMID:29880640
Cellular Component	GO:0030678	mitochondrial ribonuclease P complex	HSD17B10	IDA		Human	PMID:25925575
Cellular Component	GO:0030678	mitochondrial ribonuclease P complex	HSD17B10	IDA		Human	PMID:28888424
Cellular Component	GO:0005739	mitochondrion	HSD17B10	IDA		Human	PMID:23042678
Cellular Component	GO:0005739	mitochondrion	HSD17B10	IDA		Human	PMID:29880640
Cellular Component	GO:0005739	mitochondrion	Hsd17b10	IDA		Mouse	MGI:MGI:2682130|PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Hsd17b10	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Hsd17b10	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Hsd17b10	IDA		Mouse	PMID:24703694
Cellular Component	GO:0005739	mitochondrion	Hsd17b10	IDA		Rat	PMID:11165016|RGD:68798
Cellular Component	GO:0043527	tRNA methyltransferase complex	HSD17B10	IPI		Human	PMID:23042678
Biological Process	GO:0008209	androgen metabolic process	HSD17B10	IDA		Human	PMID:12917011
Biological Process	GO:0006699	bile acid biosynthetic process	HSD17B10	IDA		Human	PMID:12917011
Biological Process	GO:0062173	brexanolone metabolic process	HSD17B10	IDA		Human	PMID:19706438
Biological Process	GO:0008207	C21-steroid hormone metabolic process	HSD17B10	IDA		Human	PMID:12917011
Biological Process	GO:0008210	estrogen metabolic process	HSD17B10	IDA		Human	PMID:12917011
Biological Process	GO:0006635	fatty acid beta-oxidation	HSD17B10	IDA		Human	PMID:12917011
Biological Process	GO:0006550	isoleucine catabolic process	HSD17B10	IDA		Human	PMID:18996107
Biological Process	GO:0006550	isoleucine catabolic process	HSD17B10	IDA		Human	PMID:19706438
Biological Process	GO:0033327	Leydig cell differentiation	Hsd17b10	IEP		Rat	PMID:12810569|RGD:2302236
Biological Process	GO:0008584	male gonad development	Hsd17b10	IEP		Rat	PMID:12810569|RGD:2302236
Biological Process	GO:1990180	mitochondrial tRNA 3'-end processing	HSD17B10	IDA		Human	PMID:29040705
Biological Process	GO:0097745	mitochondrial tRNA 5'-end processing	HSD17B10	IDA		Human	PMID:24549042
Biological Process	GO:0097745	mitochondrial tRNA 5'-end processing	HSD17B10	IDA		Human	PMID:25925575
Biological Process	GO:0097745	mitochondrial tRNA 5'-end processing	HSD17B10	IDA		Human	PMID:28888424
Biological Process	GO:0097745	mitochondrial tRNA 5'-end processing	HSD17B10	IDA		Human	PMID:29040705
Biological Process	GO:0097745	mitochondrial tRNA 5'-end processing	HSD17B10	IDA		Human	PMID:29880640
Biological Process	GO:0070901	mitochondrial tRNA methylation	HSD17B10	IDA		Human	PMID:23042678
Biological Process	GO:0070901	mitochondrial tRNA methylation	HSD17B10	IDA		Human	PMID:25925575
Biological Process	GO:0070901	mitochondrial tRNA methylation	HSD17B10	IDA		Human	PMID:28888424
Biological Process	GO:0007005	mitochondrion organization	HSD17B10	IMP		Human	PMID:20077426
Biological Process	GO:0051289	protein homotetramerization	HSD17B10	IDA		Human	PMID:25925575

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern