Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HSD17B3
  • Mouse genes Hsd17b3
  • Rat genes Hsd17b3
  • Zfish genes hsd17b3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hsd17b3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	Hsd17b3	IDA		Rat	PMID:10433209|RGD:727276
Molecular Function	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity	HSD17B3	IDA		Human	PMID:26545797
Molecular Function	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity	hsd17b3	IDA		Zfish	PMID:16216911
Molecular Function	GO:0047035	testosterone dehydrogenase (NAD+) activity	Hsd17b3	IDA		Rat	PMID:19818404|RGD:2326078
Cellular Component	GO:0005783	endoplasmic reticulum	HSD17B3	IDA		Human	PMID:26545797
Cellular Component	GO:0005783	endoplasmic reticulum	hsd17b3	IDA		Zfish	PMID:16216911
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Hsd17b3	IDA		Rat	PMID:17936465|RGD:4889109
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Hsd17b3	IDA		Rat	PMID:19818404|RGD:2326078
Biological Process	GO:0006702	androgen biosynthetic process	hsd17b3	IDA		Zfish	PMID:16216911
Biological Process	GO:0018879	biphenyl metabolic process	Hsd17b3	IEP		Rat	PMID:18502095|RGD:4783624
Biological Process	GO:0071236	cellular response to antibiotic	Hsd17b3	IEP		Rat	PMID:18655822|RGD:4777466
Biological Process	GO:0071371	cellular response to gonadotropin stimulus	Hsd17b3	IEP		Rat	PMID:20963569|RGD:4842495
Biological Process	GO:0032870	cellular response to hormone stimulus	Hsd17b3	IEP		Rat	PMID:20204307|RGD:4890944
Biological Process	GO:0021766	hippocampus development	Hsd17b3	IEP		Rat	PMID:21047951|RGD:4145527
Biological Process	GO:0017143	insecticide metabolic process	Hsd17b3	IEP		Rat	PMID:18401575|RGD:4890969
Biological Process	GO:0033327	Leydig cell differentiation	Hsd17b3	IEP		Rat	PMID:18502897|RGD:4781870
Biological Process	GO:0006082	organic acid metabolic process	Hsd17b3	IEP		Rat	PMID:17400581|RGD:4889129
Biological Process	GO:0018958	phenol-containing compound metabolic process	Hsd17b3	IEP		Rat	PMID:19429456|RGD:4890959
Biological Process	GO:0014823	response to activity	Hsd17b3	IEP		Rat	PMID:18923565|RGD:4890966
Biological Process	GO:0046685	response to arsenic-containing substance	Hsd17b3	IEP		Rat	PMID:16483355|RGD:4889531
Biological Process	GO:0046686	response to cadmium ion	Hsd17b3	IEP		Rat	PMID:20957662|RGD:4890460
Biological Process	GO:0051412	response to corticosterone	Hsd17b3	IEP		Rat	PMID:18335507|RGD:4831835
Biological Process	GO:0043627	response to estrogen	Hsd17b3	IEP		Rat	PMID:19439821|RGD:4890957
Biological Process	GO:0045471	response to ethanol	Hsd17b3	IEP		Rat	PMID:17193892|RGD:4889530
Biological Process	GO:0070542	response to fatty acid	Hsd17b3	IEP		Rat	PMID:19130109|RGD:4889519
Biological Process	GO:0060992	response to fungicide	Hsd17b3	IEP		Rat	PMID:17485193|RGD:4890971
Biological Process	GO:0009635	response to herbicide	Hsd17b3	IEP		Rat	PMID:20667998|RGD:4145533
Biological Process	GO:0017085	response to insecticide	Hsd17b3	IEP		Rat	PMID:20211256|RGD:4890943
Biological Process	GO:0033591	response to L-ascorbic acid	Hsd17b3	IEP		Rat	PMID:17280759|RGD:4891016
Biological Process	GO:0010288	response to lead ion	Hsd17b3	IEP		Rat	PMID:19652923|RGD:4890953
Biological Process	GO:0010038	response to metal ion	Hsd17b3	IEP		Rat	PMID:17822870|RGD:4890970
Biological Process	GO:0031667	response to nutrient levels	Hsd17b3	IEP		Rat	PMID:17936465|RGD:4889109
Biological Process	GO:0031667	response to nutrient levels	Hsd17b3	IEP		Rat	PMID:19130109|RGD:4889519
Biological Process	GO:0014070	response to organic cyclic compound	Hsd17b3	IEP		Rat	PMID:18001809|RGD:4831842
Biological Process	GO:0048545	response to steroid hormone	Hsd17b3	IEP		Rat	PMID:19961867|RGD:4145605
Biological Process	GO:0033197	response to vitamin E	Hsd17b3	IEP		Rat	PMID:17280759|RGD:4891016
Biological Process	GO:0006694	steroid biosynthetic process	Hsd17b3	IDA		Rat	PMID:19818404|RGD:2326078

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern