Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HSD17B4
  • Mouse genes Hsd17b4
  • Rat genes Hsd17b4
  • Zfish genes hsd17b4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hsd17b4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity	Hsd17b4	IDA		Rat	PMID:9084892|RGD:10411901
Molecular Function	GO:0018812	3-hydroxyacyl-CoA dehydratase activity	Hsd17b4	IDA		Rat	PMID:8902630|RGD:10411904
Molecular Function	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	HSD17B4	IDA		Human	PMID:10706581
Molecular Function	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	HSD17B4	IDA		Human	PMID:15060085
Molecular Function	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	HSD17B4	IDA		Human	PMID:9089413
Molecular Function	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	HSD17B4	IDA		Human	PMID:9482850
Molecular Function	GO:0004300	enoyl-CoA hydratase activity	HSD17B4	IDA		Human	PMID:10706581
Molecular Function	GO:0004300	enoyl-CoA hydratase activity	HSD17B4	IDA		Human	PMID:15060085
Molecular Function	GO:0004300	enoyl-CoA hydratase activity	HSD17B4	IDA		Human	PMID:9482850
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	HSD17B4	IDA		Human	PMID:7487879
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	Hsd17b4	IDA		Rat	PMID:12225901|RGD:10411898
Molecular Function	GO:0042802	identical protein binding	Hsd17b4	IPI	RGD:621806	Rat	PMID:20566640|RGD:10411882
Molecular Function	GO:0016508	long-chain-enoyl-CoA hydratase activity	HSD17B4	IDA		Human	PMID:10400999
Molecular Function	GO:0016508	long-chain-enoyl-CoA hydratase activity	HSD17B4	IDA		Human	PMID:9089413
Molecular Function	GO:0016508	long-chain-enoyl-CoA hydratase activity	HSD17B4	IDA		Human	PMID:9482850
Molecular Function	GO:0005515	protein binding	Hsd17b4	IPI	UniProtKB:P42858	Mouse	MGI:MGI:6467711|PMID:32814053
Molecular Function	GO:0042803	protein homodimerization activity	HSD17B4	IDA		Human	PMID:15644212
Molecular Function	GO:0042803	protein homodimerization activity	HSD17B4	IDA		Human	PMID:9089413
Cellular Component	GO:0016020	membrane	HSD17B4	HDA		Human	PMID:16210410
Cellular Component	GO:0005739	mitochondrion	Hsd17b4	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Hsd17b4	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005778	peroxisomal membrane	HSD17B4	HDA		Human	PMID:21525035
Cellular Component	GO:0005777	peroxisome	HSD17B4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005777	peroxisome	HSD17B4	IDA		Human	PMID:15599942
Cellular Component	GO:0005777	peroxisome	Hsd17b4	IDA		Mouse	PMID:12897163
Cellular Component	GO:0005777	peroxisome	Hsd17b4	IDA		Rat	PMID:14561759|RGD:1580664
Cellular Component	GO:0005777	peroxisome	Hsd17b4	IDA		Rat	PMID:16484321|RGD:1599970
Biological Process	GO:0007568	aging	Hsd17b4	IEP		Rat	PMID:25019473|RGD:10411881
Biological Process	GO:0008209	androgen metabolic process	HSD17B4	IDA		Human	PMID:7487879
Biological Process	GO:0071407	cellular response to organic cyclic compound	Hsd17b4	IEP		Rat	PMID:12706301|RGD:10411897
Biological Process	GO:0048568	embryonic organ development	hsd17b4	IMP	ZFIN:ZDB-MRPHLNO-160907-3	Zfish	PMID:24552713
Biological Process	GO:0008210	estrogen metabolic process	HSD17B4	IDA		Human	PMID:7487879
Biological Process	GO:0006635	fatty acid beta-oxidation	HSD17B4	IDA		Human	PMID:10400999
Biological Process	GO:0006635	fatty acid beta-oxidation	HSD17B4	IDA		Human	PMID:10706581
Biological Process	GO:0006635	fatty acid beta-oxidation	HSD17B4	IDA		Human	PMID:15060085
Biological Process	GO:0006635	fatty acid beta-oxidation	HSD17B4	IDA		Human	PMID:9482850
Biological Process	GO:0006635	fatty acid beta-oxidation	Hsd17b4	IMP	MGI:MGI:2385822	Mouse	PMID:17442273
Biological Process	GO:0036112	medium-chain fatty-acyl-CoA metabolic process	HSD17B4	IDA		Human	PMID:9089413
Biological Process	GO:0048666	neuron development	hsd17b4	IMP	ZFIN:ZDB-MRPHLNO-160907-3	Zfish	PMID:24552713
Biological Process	GO:0001649	osteoblast differentiation	HSD17B4	HDA		Human	PMID:16210410
Biological Process	GO:0014070	response to organic cyclic compound	Hsd17b4	IEP		Rat	PMID:16038268|RGD:10411895
Biological Process	GO:0048545	response to steroid hormone	Hsd17b4	IEP		Rat	PMID:25603467|RGD:10411879
Biological Process	GO:0009410	response to xenobiotic stimulus	Hsd17b4	IEP		Rat	PMID:9209713|RGD:10411902
Biological Process	GO:0060009	Sertoli cell development	Hsd17b4	IMP	MGI:MGI:2385822	Mouse	PMID:16484321
Biological Process	GO:0000038	very long-chain fatty acid metabolic process	Hsd17b4	IMP	MGI:MGI:2385822	Mouse	PMID:16484321
Biological Process	GO:0036111	very long-chain fatty-acyl-CoA metabolic process	HSD17B4	IDA		Human	PMID:9482850

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern