Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hsd3b1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HSD3B1,HSD3B2
- Mouse genes Hsd3b1
- Rat genes Hsd3b1,Hsd3b3
- Zfish genes hsd3b1,hsd3b2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hsd3b1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	HSD3B2	IDA		Human	PMID:1944309
Molecular Function	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	HSD3B2	IMP		Human	PMID:25322271
Molecular Function	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	Hsd3b1	IDA		Rat	PMID:1537836\|RGD:13825195
Molecular Function	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	Hsd3b1	IDA		Rat	PMID:1955079\|RGD:1625116
Molecular Function	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	hsd3b2	IDA		Zfish	PMID:25974401
Molecular Function	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	hsd3b1	IDA		Zfish	PMID:25974401
Molecular Function	GO:0035410	dihydrotestosterone 17-beta-dehydrogenase activity	Hsd3b1	IDA		Rat	PMID:1309351\|RGD:4889582
Molecular Function	GO:0051287	NAD binding	Hsd3b1	IDA		Rat	PMID:1955079\|RGD:1625116
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:Q7RTY0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:P27797	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:P36957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:Q8TDX7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSD3B2	IPI	UniProtKB:Q53GS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSD3B2	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005496	steroid binding	Hsd3b1	IPI	CHEBI:16581	Rat	PMID:1955079\|RGD:1625116
Molecular Function	GO:0005496	steroid binding	Hsd3b1	IPI	CHEBI:28689	Rat	PMID:1955079\|RGD:1625116
Molecular Function	GO:0005496	steroid binding	Hsd3b1	IPI	CHEBI:28750	Rat	PMID:1955079\|RGD:1625116
Molecular Function	GO:0004769	steroid delta-isomerase activity	HSD3B2	IDA		Human	PMID:1944309
Molecular Function	GO:0004769	steroid delta-isomerase activity	HSD3B2	IMP		Human	PMID:25322271
Molecular Function	GO:0004769	steroid delta-isomerase activity	Hsd3b1	IDA		Rat	PMID:1537836\|RGD:13825195
Molecular Function	GO:0004769	steroid delta-isomerase activity	Hsd3b1	IDA		Rat	PMID:1985917\|RGD:632871
Cellular Component	GO:0005783	endoplasmic reticulum	HSD3B1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	HSD3B2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	HSD3B2	IMP		Human	PMID:25322271
Cellular Component	GO:0045171	intercellular bridge	HSD3B1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045171	intercellular bridge	HSD3B2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Hsd3b1	IDA		Rat	PMID:17936465\|RGD:4889109
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Hsd3b1	IDA		Rat	PMID:1944305\|RGD:632872
Cellular Component	GO:0030061	mitochondrial crista	Hsd3b1	IDA		Rat	PMID:9065457\|RGD:4889558
Cellular Component	GO:0005743	mitochondrial inner membrane	HSD3B1	IDA		Human	PMID:8274411
Cellular Component	GO:0005758	mitochondrial intermembrane space	HSD3B1	IDA		Human	PMID:8274411
Cellular Component	GO:0005739	mitochondrion	Hsd3b1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005730	nucleolus	HSD3B1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	HSD3B2	IDA		Human	GO_REF:0000052
Biological Process	GO:0030325	adrenal gland development	Hsd3b1	IEP		Rat	PMID:1935797\|RGD:4889583
Biological Process	GO:0006702	androgen biosynthetic process	HSD3B2	IMP		Human	PMID:25322271
Biological Process	GO:0018879	biphenyl metabolic process	Hsd3b1	IEP		Rat	PMID:19071209\|RGD:4768197
Biological Process	GO:0008207	C21-steroid hormone metabolic process	Hsd3b1	IDA		Rat	PMID:19190754\|RGD:4889515
Biological Process	GO:0071236	cellular response to antibiotic	Hsd3b1	IEP		Rat	PMID:18655822\|RGD:4777466
Biological Process	GO:0071320	cellular response to cAMP	Hsd3b1	IEP		Rat	PMID:1312436\|RGD:4889580
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Hsd3b1	IEP		Rat	PMID:20075416\|RGD:4145599
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	Hsd3b1	IEP		Rat	PMID:17494997\|RGD:2289861
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	Hsd3b1	IEP		Rat	PMID:20810564\|RGD:4145531
Biological Process	GO:0071333	cellular response to glucose stimulus	Hsd3b1	IEP		Rat	PMID:18353182\|RGD:4785271
Biological Process	GO:0071371	cellular response to gonadotropin stimulus	Hsd3b1	IEP		Rat	PMID:8142315\|RGD:4889560
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Hsd3b1	IEP		Rat	PMID:16374549\|RGD:4889541
Biological Process	GO:0032869	cellular response to insulin stimulus	Hsd3b1	IEP		Rat	PMID:2177628\|RGD:4889586
Biological Process	GO:0071373	cellular response to luteinizing hormone stimulus	Hsd3b1	IEP		Rat	PMID:1312436\|RGD:4889580
Biological Process	GO:0071288	cellular response to mercury ion	Hsd3b1	IEP		Rat	PMID:2253967\|RGD:4889587
Biological Process	GO:0071406	cellular response to methylmercury	Hsd3b1	IEP		Rat	PMID:2253967\|RGD:4889587
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Hsd3b1	IEP		Rat	PMID:18511507\|RGD:4781450
Biological Process	GO:0018894	dibenzo-p-dioxin metabolic process	Hsd3b1	IEP		Rat	PMID:18637154\|RGD:4778755
Biological Process	GO:0016101	diterpenoid metabolic process	Hsd3b1	IEP		Rat	PMID:1312436\|RGD:4889580
Biological Process	GO:0048598	embryonic morphogenesis	hsd3b2	IMP	ZFIN:ZDB-MRPHLNO-060301-5	Zfish	PMID:25974401
Biological Process	GO:0008585	female gonad development	Hsd3b1	IEP		Rat	PMID:8439611\|RGD:4889563
Biological Process	GO:0030851	granulocyte differentiation	Hsd3b1	IEP		Rat	PMID:18401763\|RGD:4784626
Biological Process	GO:0021766	hippocampus development	Hsd3b1	IEP		Rat	PMID:21047951\|RGD:4145527
Biological Process	GO:0017143	insecticide metabolic process	Hsd3b1	IEP		Rat	PMID:18401575\|RGD:4890969
Biological Process	GO:0033327	Leydig cell differentiation	Hsd3b1	IEP		Rat	PMID:18502897\|RGD:4781870
Biological Process	GO:0008584	male gonad development	Hsd3b1	IEP		Rat	PMID:18772241\|RGD:2303053
Biological Process	GO:0060135	maternal process involved in female pregnancy	Hsd3b1	IEP		Rat	PMID:17257522\|RGD:4889524
Biological Process	GO:0006082	organic acid metabolic process	Hsd3b1	IEP		Rat	PMID:17400581\|RGD:4889129
Biological Process	GO:0030728	ovulation	Hsd3b1	IEP		Rat	PMID:19775733\|RGD:4888508
Biological Process	GO:0018958	phenol-containing compound metabolic process	Hsd3b1	IEP		Rat	PMID:19429456\|RGD:4890959
Biological Process	GO:0046470	phosphatidylcholine metabolic process	Hsd3b1	IEP		Rat	PMID:2590715\|RGD:4889588
Biological Process	GO:0043473	pigmentation	hsd3b1	IMP	ZFIN:ZDB-MRPHLNO-151022-4	Zfish	PMID:25974401
Biological Process	GO:0006701	progesterone biosynthetic process	Hsd3b1	IDA		Rat	PMID:1955079\|RGD:1625116
Biological Process	GO:0014823	response to activity	Hsd3b1	IEP		Rat	PMID:18923565\|RGD:4890966
Biological Process	GO:0043279	response to alkaloid	Hsd3b1	IEP		Rat	PMID:18772241\|RGD:2303053
Biological Process	GO:0046685	response to arsenic-containing substance	Hsd3b1	IEP		Rat	PMID:16483355\|RGD:4889531
Biological Process	GO:0046686	response to cadmium ion	Hsd3b1	IEP		Rat	PMID:18972398\|RGD:4890965
Biological Process	GO:0051592	response to calcium ion	Hsd3b1	IEP		Rat	PMID:16472573\|RGD:4891020
Biological Process	GO:0051412	response to corticosterone	Hsd3b1	IEP		Rat	PMID:18335507\|RGD:4831835
Biological Process	GO:0032355	response to estradiol	Hsd3b1	IEP		Rat	PMID:16020475\|RGD:4889552
Biological Process	GO:0045471	response to ethanol	Hsd3b1	IEP		Rat	PMID:17193892\|RGD:4889530
Biological Process	GO:0070542	response to fatty acid	Hsd3b1	IEP		Rat	PMID:19130109\|RGD:4889519
Biological Process	GO:0060992	response to fungicide	Hsd3b1	IEP		Rat	PMID:17485193\|RGD:4890971
Biological Process	GO:0009635	response to herbicide	Hsd3b1	IEP		Rat	PMID:20045047\|RGD:4890945
Biological Process	GO:0033591	response to L-ascorbic acid	Hsd3b1	IEP		Rat	PMID:17280759\|RGD:4891016
Biological Process	GO:0010288	response to lead ion	Hsd3b1	IEP		Rat	PMID:18972398\|RGD:4890965
Biological Process	GO:0010226	response to lithium ion	Hsd3b1	IEP		Rat	PMID:14972747\|RGD:4889553
Biological Process	GO:0010038	response to metal ion	Hsd3b1	IEP		Rat	PMID:17822870\|RGD:4890970
Biological Process	GO:0031667	response to nutrient levels	Hsd3b1	IEP		Rat	PMID:19130109\|RGD:4889519
Biological Process	GO:0014070	response to organic cyclic compound	Hsd3b1	IEP		Rat	PMID:18606229\|RGD:4781442
Biological Process	GO:0014070	response to organic cyclic compound	Hsd3b1	IEP		Rat	PMID:28208728\|RGD:151893505
Biological Process	GO:0010033	response to organic substance	Hsd3b1	IEP		Rat	PMID:18804513\|RGD:4772578
Biological Process	GO:0033197	response to vitamin E	Hsd3b1	IEP		Rat	PMID:17280759\|RGD:4891016
Biological Process	GO:0009410	response to xenobiotic stimulus	Hsd3b1	IEP		Rat	PMID:18772241\|RGD:2303053
Biological Process	GO:0006694	steroid biosynthetic process	HSD3B2	IDA		Human	PMID:1944309
Biological Process	GO:0006694	steroid biosynthetic process	HSD3B2	IMP		Human	PMID:25322271
Biological Process	GO:0006694	steroid biosynthetic process	hsd3b2	IMP	ZFIN:ZDB-MRPHLNO-060301-5	Zfish	PMID:16437115
Biological Process	GO:0008202	steroid metabolic process	Hsd3b1	IDA		Rat	PMID:1955079\|RGD:1625116
Biological Process	GO:0061370	testosterone biosynthetic process	Hsd3b1	IEP		Rat	PMID:16467141\|RGD:4889544
Biological Process	GO:0018970	toluene metabolic process	Hsd3b1	IEP		Rat	PMID:19110042\|RGD:4766784

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.