Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HSD3B1,HSD3B2
  • Mouse genes Hsd3b6
  • Rat genes Hsd3b2
  • Zfish genes hsd3b1,hsd3b2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hsd3b6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	HSD3B2	IDA		Human	PMID:1944309
Molecular Function	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	HSD3B2	IMP		Human	PMID:25322271
Molecular Function	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	Hsd3b2	IDA		Rat	PMID:1985917|RGD:632871
Molecular Function	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	hsd3b2	IDA		Zfish	PMID:25974401
Molecular Function	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	hsd3b1	IDA		Zfish	PMID:25974401
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:Q7RTY0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:P27797	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:P36957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSD3B1	IPI	UniProtKB:Q8TDX7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSD3B2	IPI	UniProtKB:Q53GS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSD3B2	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0004769	steroid delta-isomerase activity	HSD3B2	IDA		Human	PMID:1944309
Molecular Function	GO:0004769	steroid delta-isomerase activity	HSD3B2	IMP		Human	PMID:25322271
Molecular Function	GO:0004769	steroid delta-isomerase activity	Hsd3b2	IDA		Rat	PMID:1985917|RGD:632871
Cellular Component	GO:0005783	endoplasmic reticulum	HSD3B1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	HSD3B2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	HSD3B2	IMP		Human	PMID:25322271
Cellular Component	GO:0045171	intercellular bridge	HSD3B1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045171	intercellular bridge	HSD3B2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005743	mitochondrial inner membrane	HSD3B1	IDA		Human	PMID:8274411
Cellular Component	GO:0005758	mitochondrial intermembrane space	HSD3B1	IDA		Human	PMID:8274411
Cellular Component	GO:0005730	nucleolus	HSD3B1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	HSD3B2	IDA		Human	GO_REF:0000052
Biological Process	GO:0006702	androgen biosynthetic process	HSD3B2	IMP		Human	PMID:25322271
Biological Process	GO:0006702	androgen biosynthetic process	Hsd3b2	IDA		Rat	PMID:1985917|RGD:632871
Biological Process	GO:0006700	C21-steroid hormone biosynthetic process	Hsd3b2	IDA		Rat	PMID:1985917|RGD:632871
Biological Process	GO:0048598	embryonic morphogenesis	hsd3b2	IMP	ZFIN:ZDB-MRPHLNO-060301-5	Zfish	PMID:25974401
Biological Process	GO:0021766	hippocampus development	Hsd3b2	IEP		Rat	PMID:21047951|RGD:4145527
Biological Process	GO:0033327	Leydig cell differentiation	Hsd3b2	IEP		Rat	PMID:18502897|RGD:4781870
Biological Process	GO:0034757	negative regulation of iron ion transport	Hsd3b2	IMP		Rat	PMID:16116051|RGD:1599701
Biological Process	GO:0043473	pigmentation	hsd3b1	IMP	ZFIN:ZDB-MRPHLNO-151022-4	Zfish	PMID:25974401
Biological Process	GO:0046686	response to cadmium ion	Hsd3b2	IEP		Rat	PMID:18972398|RGD:4890965
Biological Process	GO:0051412	response to corticosterone	Hsd3b2	IEP		Rat	PMID:8027581|RGD:4889559
Biological Process	GO:0034698	response to gonadotropin	Hsd3b2	IEP		Rat	PMID:16139340|RGD:4145663
Biological Process	GO:0010288	response to lead ion	Hsd3b2	IEP		Rat	PMID:18972398|RGD:4890965
Biological Process	GO:0006694	steroid biosynthetic process	HSD3B2	IDA		Human	PMID:1944309
Biological Process	GO:0006694	steroid biosynthetic process	HSD3B2	IMP		Human	PMID:25322271
Biological Process	GO:0006694	steroid biosynthetic process	hsd3b2	IMP	ZFIN:ZDB-MRPHLNO-060301-5	Zfish	PMID:16437115

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern