Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HSF4
  • Mouse genes Hsf4
  • Rat genes Hsf4
  • Zfish genes hsf4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hsf4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Hsf4	IDA		Mouse	MGI:MGI:3821682|PMID:18755693
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Hsf4	IMP		Mouse	MGI:MGI:3821682|PMID:18755693
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	HSF4	IDA		Human	PMID:8972228
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Hsf4	IDA		Mouse	MGI:MGI:3821682|PMID:18755693
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Hsf4	IMP		Mouse	MGI:MGI:3821682|PMID:18755693
Molecular Function	GO:0042802	identical protein binding	Hsf4	IPI	RGD:1310808	Rat	PMID:15308659|RGD:1599777
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	HSF4	IDA		Human	PMID:8972228
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Hsf4	IDA		Mouse	MGI:MGI:3821682|PMID:18755693
Molecular Function	GO:0043565	sequence-specific DNA binding	Hsf4	IDA		Rat	PMID:15308659|RGD:1599777
Molecular Function	GO:0043565	sequence-specific DNA binding	hsf4	IDA		Zfish	PMID:22528049
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	HSF4	IDA		Human	PMID:28473536
Cellular Component	GO:0000785	chromatin	HSF4	IDA		Human	PMID:8972228
Cellular Component	GO:0016607	nuclear speck	HSF4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Hsf4	IDA		Rat	PMID:15308659|RGD:1599777
Biological Process	GO:0070306	lens fiber cell differentiation	hsf4	IMP		Zfish	PMID:33854238|ZFIN:ZDB-PUB-210416-4
Biological Process	GO:0070306	lens fiber cell differentiation	hsf4	IMP	ZFIN:ZDB-GENO-180410-2	Zfish	PMID:32061775
Biological Process	GO:0070306	lens fiber cell differentiation	hsf4	IMP	ZFIN:ZDB-MRPHLNO-120716-1	Zfish	PMID:23507146
Biological Process	GO:0002089	lens morphogenesis in camera-type eye	hsf4	IMP	ZFIN:ZDB-MRPHLNO-120716-1	Zfish	PMID:22587838
Biological Process	GO:0036438	maintenance of lens transparency	hsf4	IMP	ZFIN:ZDB-GENO-210204-2	Zfish	PMID:31786107
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hsf4	IMP		Rat	PMID:17196161|RGD:1599779
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HSF4	IDA		Human	PMID:8972228
Biological Process	GO:0032077	positive regulation of deoxyribonuclease activity	hsf4	IMP	ZFIN:ZDB-MRPHLNO-120716-1	Zfish	PMID:23507146
Biological Process	GO:1902746	regulation of lens fiber cell differentiation	hsf4	IMP	ZFIN:ZDB-GENO-180410-2	Zfish	PMID:28981088

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern