Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hspa1b

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HSPA1B
- Mouse genes Hspa1b
- Rat genes Hspa1a,Hspa1b
- Zfish genes hsp70.1,hsp70.2,hsp70.3,hsp70l,hspa1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hspa1b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	HSPA1B	IDA		Human	PMID:23921388
Molecular Function	GO:0016887	ATP hydrolysis activity	HSPA1B	IDA		Human	PMID:21231916
Molecular Function	GO:0140545	ATP-dependent protein disaggregase activity	HSPA1B	IDA		Human	PMID:23921388
Molecular Function	GO:0055131	C3HC4-type RING finger domain binding	HSPA1B	IPI	UniProtKB:Q6ZRF8	Human	PMID:25281747
Molecular Function	GO:0019899	enzyme binding	HSPA1B	IPI	UniProtKB:Q8WXB1	Human	PMID:23921388
Molecular Function	GO:0001664	G protein-coupled receptor binding	HSPA1B	IDA		Human	PMID:12150907
Molecular Function	GO:0031072	heat shock protein binding	HSPA1B	IPI	UniProtKB:Q8WXX5	Human	PMID:17182002
Molecular Function	GO:0031072	heat shock protein binding	HSPA1B	IPI	UniProtKB:O60884	Human	PMID:21231916
Molecular Function	GO:0031072	heat shock protein binding	HSPA1B	IPI	UniProtKB:O75190	Human	PMID:21231916
Molecular Function	GO:0031072	heat shock protein binding	HSPA1B	IPI	UniProtKB:O75953	Human	PMID:21231916
Molecular Function	GO:0031072	heat shock protein binding	HSPA1B	IPI	UniProtKB:P25685	Human	PMID:21231916
Molecular Function	GO:0031072	heat shock protein binding	HSPA1B	IPI	UniProtKB:P25686	Human	PMID:21231916
Molecular Function	GO:0031072	heat shock protein binding	HSPA1B	IPI	UniProtKB:P31689	Human	PMID:21231916
Molecular Function	GO:0031072	heat shock protein binding	HSPA1B	IPI	UniProtKB:Q7Z6W7	Human	PMID:21231916
Molecular Function	GO:0031072	heat shock protein binding	HSPA1B	IPI	UniProtKB:Q8NHS0	Human	PMID:21231916
Molecular Function	GO:0031072	heat shock protein binding	HSPA1B	IPI	UniProtKB:Q8WW22	Human	PMID:21231916
Molecular Function	GO:0031072	heat shock protein binding	HSPA1B	IPI	UniProtKB:Q9UDY4	Human	PMID:21231916
Molecular Function	GO:0031072	heat shock protein binding	HSPA1B	IPI	UniProtKB:P25685	Human	PMID:23921388
Molecular Function	GO:0042826	histone deacetylase binding	HSPA1B	IPI	UniProtKB:Q9BY41	Human	PMID:16809764
Molecular Function	GO:0051059	NF-kappaB binding	Hspa1a	IPI	RGD:70498	Rat	PMID:16135962\|RGD:1598788
Molecular Function	GO:0002020	protease binding	Hspa1a	IPI	RGD:733294	Rat	PMID:16397188\|RGD:1626654
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:Q9UL15	Human	PMID:15603737
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:P37840	Human	PMID:15671022
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:P37840	Human	PMID:18975920
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:Q9CRB9	Human	PMID:21081504
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:Q9Y2D1	Human	PMID:22528486
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:O95568	Human	PMID:23349634
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:Q5VZV1	Human	PMID:23349634
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:Q7Z624	Human	PMID:23349634
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:Q8WXB1	Human	PMID:23349634
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:Q96AZ1	Human	PMID:23349634
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:Q9BUU2	Human	PMID:23349634
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:O95816	Human	PMID:24318877
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:O95817	Human	PMID:24318877
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:Q92598	Human	PMID:24318877
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:Q99933	Human	PMID:24318877
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:O75937	Human	PMID:27133716
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:Q8NHV4	Human	PMID:27137183
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:P41227	Human	PMID:27708256
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:P56524	Human	PMID:27708256
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:Q9BPY8	Human	PMID:27708256
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:Q9UNE7	Human	PMID:27708256
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:P55085	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:Q8WXX5	Human	PMID:33857403
Molecular Function	GO:0005515	protein binding	HSPA1B	IPI	UniProtKB:P19544	Human	PMID:9553041
Molecular Function	GO:0005515	protein binding	Hspa1b	IPI	UniProtKB:P70196	Mouse	MGI:MGI:3629375\|PMID:16697380
Molecular Function	GO:0005515	protein binding	Hspa1b	IPI	UniProtKB:P28301	Mouse	MGI:MGI:5008506\|PMID:21536655
Molecular Function	GO:0005515	protein binding	Hspa1b	IPI	PR:Q99M87	Mouse	PMID:11116152
Molecular Function	GO:0005515	protein binding	Hspa1b	IPI	PR:Q8CI61	Mouse	PMID:11527400
Molecular Function	GO:0005515	protein binding	Hspa1b	IPI	PR:Q99KV1	Mouse	PMID:11584023
Molecular Function	GO:0005515	protein binding	Hspa1b	IPI	PR:Q9JLV1	Mouse	PMID:11527400
Molecular Function	GO:0005515	protein binding	Hspa1b	IPI	UniProtKB:P49952	Rat	PMID:9553041\|RGD:8554177
Molecular Function	GO:0005515	protein binding	Hspa1a	IPI	RGD:3171	Rat	PMID:16135962\|RGD:1598788
Molecular Function	GO:0005515	protein binding	Hspa1a	IPI	UniProtKB:P49952	Rat	PMID:9553041\|RGD:8554177
Molecular Function	GO:0044183	protein folding chaperone	HSPA1B	IDA		Human	PMID:15603737
Molecular Function	GO:0044183	protein folding chaperone	Hspa1b	IDA		Mouse	MGI:MGI:6316406\|PMID:27496612
Molecular Function	GO:0003723	RNA binding	HSPA1B	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	HSPA1B	HDA		Human	PMID:22681889
Molecular Function	GO:0005102	signaling receptor binding	HSPA1B	IPI	UniProtKB:Q9HC29	Human	PMID:24790089
Molecular Function	GO:0031625	ubiquitin protein ligase binding	HSPA1B	IPI	UniProtKB:O60260	Human	PMID:12150907
Molecular Function	GO:0031625	ubiquitin protein ligase binding	HSPA1B	IPI	UniProtKB:O60260	Human	PMID:15603737
Molecular Function	GO:0051082	unfolded protein binding	HSPA1B	IDA		Human	PMID:21231916
Cellular Component	GO:0016235	aggresome	HSPA1B	IDA		Human	PMID:15885686
Cellular Component	GO:0016324	apical plasma membrane	Hspa1a	IDA		Rat	PMID:16609151\|RGD:1626653
Cellular Component	GO:0016323	basolateral plasma membrane	Hspa1a	IDA		Rat	PMID:16609151\|RGD:1626653
Cellular Component	GO:0072562	blood microparticle	HSPA1B	HDA		Human	PMID:22516433
Cellular Component	GO:0044297	cell body	Hspa1b	IDA		Mouse	PMID:21880732
Cellular Component	GO:0005814	centriole	HSPA1B	IDA		Human	PMID:24061851
Cellular Component	GO:0005813	centrosome	HSPA1B	IDA		Human	PMID:27137183
Cellular Component	GO:0005737	cytoplasm	HSPA1B	IDA		Human	PMID:10859165
Cellular Component	GO:0005737	cytoplasm	HSPA1B	IDA		Human	PMID:24061851
Cellular Component	GO:0005737	cytoplasm	HSPA1B	IDA		Human	PMID:24790089
Cellular Component	GO:0005737	cytoplasm	HSPA1B	IDA		Human	PMID:9553041
Cellular Component	GO:0005829	cytosol	HSPA1B	IDA		Human	PMID:21231916
Cellular Component	GO:0005829	cytosol	Hspa1a	IDA		Rat	PMID:16135962\|RGD:1598788
Cellular Component	GO:0005829	cytosol	Hspa1a	IDA		Rat	PMID:16609151\|RGD:1626653
Cellular Component	GO:0070062	extracellular exosome	HSPA1B	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	HSPA1B	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	HSPA1B	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	HSPA1B	HDA		Human	PMID:21423176
Cellular Component	GO:0016234	inclusion body	HSPA1B	IDA		Human	PMID:15603737
Cellular Component	GO:0005622	intracellular anatomical structure	Hspa1b	IDA		Mouse	PMID:9122205
Cellular Component	GO:0045121	membrane raft	Hspa1b	IDA		Rat	PMID:14499952\|RGD:12793007
Cellular Component	GO:0045121	membrane raft	Hspa1a	IDA		Rat	PMID:14499952\|RGD:12793007
Cellular Component	GO:0005739	mitochondrion	Hspa1b	IDA		Mouse	PMID:17376863
Cellular Component	GO:0016607	nuclear speck	HSPA1B	IDA		Human	PMID:9553041
Cellular Component	GO:0005634	nucleus	HSPA1B	IDA		Human	PMID:10205060
Cellular Component	GO:0005634	nucleus	HSPA1B	IDA		Human	PMID:17167422
Cellular Component	GO:0005634	nucleus	Hspa1a	IDA		Rat	PMID:15543931\|RGD:1626659
Cellular Component	GO:0048471	perinuclear region of cytoplasm	HSPA1B	IDA		Human	PMID:10205060
Cellular Component	GO:0048471	perinuclear region of cytoplasm	HSPA1B	IDA		Human	PMID:15603737
Cellular Component	GO:0032991	protein-containing complex	HSPA1B	IDA		Human	PMID:23349634
Cellular Component	GO:0032991	protein-containing complex	Hspa1a	IDA		Rat	PMID:16135962\|RGD:1598788
Cellular Component	GO:1990904	ribonucleoprotein complex	HSPA1B	IDA		Human	PMID:17289661
Cellular Component	GO:0031982	vesicle	HSPA1B	HDA		Human	PMID:19190083
Cellular Component	GO:0002199	zona pellucida receptor complex	Hspa1b	IDA		Mouse	PMID:21880732
Biological Process	GO:0046034	ATP metabolic process	HSPA1B	IDA		Human	PMID:23921388
Biological Process	GO:0007339	binding of sperm to zona pellucida	Hspa1b	IDA		Mouse	PMID:21880732
Biological Process	GO:0001568	blood vessel development	hsp70l	IMP	ZFIN:ZDB-MRPHLNO-121213-3	Zfish	PMID:23139789
Biological Process	GO:0048593	camera-type eye morphogenesis	hsp70.3	IMP	ZFIN:ZDB-MRPHLNO-050726-2	Zfish	PMID:15832949
Biological Process	GO:0048593	camera-type eye morphogenesis	hsp70.1	IMP	ZFIN:ZDB-MRPHLNO-050726-1	Zfish	PMID:15832949
Biological Process	GO:0070370	cellular heat acclimation	HSPA1B	IMP		Human	PMID:21231916
Biological Process	GO:0034605	cellular response to heat	HSPA1B	IDA		Human	PMID:24061851
Biological Process	GO:0006952	defense response	Hspa1a	IDA		Rat	PMID:11820796\|RGD:625446
Biological Process	GO:0060216	definitive hemopoiesis	hsp70l	IMP	ZFIN:ZDB-MRPHLNO-121213-3	Zfish	PMID:24787902
Biological Process	GO:0060216	definitive hemopoiesis	hsp70l	IGI	ZFIN:ZDB-MRPHLNO-121213-3,ZFIN:ZDB-MRPHLNO-160211-6	Zfish	PMID:24787902
Biological Process	GO:0006402	mRNA catabolic process	HSPA1B	IDA		Human	PMID:10205060
Biological Process	GO:0043066	negative regulation of apoptotic process	HSPA1B	IMP		Human	PMID:17167422
Biological Process	GO:0043066	negative regulation of apoptotic process	Hspa1b	IDA		Mouse	PMID:11879190
Biological Process	GO:0043066	negative regulation of apoptotic process	Hspa1b	IMP		Rat	PMID:16394269\|RGD:10402538
Biological Process	GO:0043066	negative regulation of apoptotic process	Hspa1a	IDA		Rat	PMID:16397188\|RGD:1626654
Biological Process	GO:0060548	negative regulation of cell death	HSPA1B	IDA		Human	PMID:12150907
Biological Process	GO:0060548	negative regulation of cell death	HSPA1B	IMP		Human	PMID:21231916
Biological Process	GO:0030308	negative regulation of cell growth	HSPA1B	IMP		Human	PMID:9553041
Biological Process	GO:0008285	negative regulation of cell population proliferation	HSPA1B	IMP		Human	PMID:9553041
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Hspa1b	IDA		Mouse	PMID:11879190
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Hspa1a	IDA		Rat	PMID:16397188\|RGD:1626654
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	HSPA1B	IMP		Human	PMID:17167422
Biological Process	GO:0090084	negative regulation of inclusion body assembly	HSPA1B	IDA		Human	PMID:15603737
Biological Process	GO:0090084	negative regulation of inclusion body assembly	HSPA1B	IDA		Human	PMID:21231916
Biological Process	GO:0031397	negative regulation of protein ubiquitination	HSPA1B	IDA		Human	PMID:12150907
Biological Process	GO:0045906	negative regulation of vasoconstriction	Hspa1a	IMP		Rat	PMID:15381648\|RGD:1626660
Biological Process	GO:0030182	neuron differentiation	Hspa1b	IEP		Rat	PMID:23000394\|RGD:7257594
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	HSPA1B	IMP		Human	PMID:17167422
Biological Process	GO:0010628	positive regulation of gene expression	HSPA1B	IMP		Human	PMID:25281747
Biological Process	GO:0032757	positive regulation of interleukin-8 production	HSPA1B	IMP	UniProtKB:Q9HC29	Human	PMID:24790089
Biological Process	GO:0090063	positive regulation of microtubule nucleation	HSPA1B	IMP		Human	PMID:27137183
Biological Process	GO:0045666	positive regulation of neuron differentiation	Hspa1b	IMP		Rat	PMID:23000394\|RGD:7257594
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	HSPA1B	IMP	UniProtKB:Q9HC29	Human	PMID:24790089
Biological Process	GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	HSPA1B	IMP	UniProtKB:Q9HC29	Human	PMID:24790089
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	Hspa1a	IDA		Rat	PMID:10679071\|RGD:1298959
Biological Process	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	HSPA1B	IMP	UniProtKB:Q9HC29	Human	PMID:24790089
Biological Process	GO:0006457	protein folding	Hspa1b	IDA		Mouse	MGI:MGI:6316406\|PMID:27496612
Biological Process	GO:0042026	protein refolding	HSPA1B	IDA		Human	PMID:15603737
Biological Process	GO:0042026	protein refolding	HSPA1B	IDA		Human	PMID:21231916
Biological Process	GO:0042026	protein refolding	HSPA1B	IMP		Human	PMID:27708256
Biological Process	GO:0050821	protein stabilization	HSPA1B	IMP		Human	PMID:24790089
Biological Process	GO:1901673	regulation of mitotic spindle assembly	HSPA1B	IMP		Human	PMID:27137183
Biological Process	GO:0031396	regulation of protein ubiquitination	HSPA1B	IDA		Human	PMID:16809764
Biological Process	GO:0046686	response to cadmium ion	hsp70l	IDA		Zfish	PMID:17706735
Biological Process	GO:0046686	response to cadmium ion	hsp70.1	IEP		Zfish	PMID:16799861
Biological Process	GO:0045471	response to ethanol	Hspa1b	IEP		Rat	PMID:23047067\|RGD:7257599
Biological Process	GO:0009408	response to heat	Hspa1b	IDA		Mouse	PMID:18755693
Biological Process	GO:0009408	response to heat	hsp70l	IDA		Zfish	PMID:10751183
Biological Process	GO:0009408	response to heat	hsp70.1	IDA		Zfish	PMID:10751183
Biological Process	GO:0002931	response to ischemia	Hspa1b	IEP		Rat	PMID:22526757\|RGD:7257595
Biological Process	GO:0009612	response to mechanical stimulus	Hspa1b	IEP		Rat	PMID:20809232\|RGD:5147602
Biological Process	GO:0010038	response to metal ion	hsp70l	IDA		Zfish	PMID:26354112
Biological Process	GO:0009314	response to radiation	Hspa1b	IEP		Rat	PMID:18302488\|RGD:7257605
Biological Process	GO:0006986	response to unfolded protein	Hspa1b	IMP		Rat	PMID:12397389\|RGD:1300068
Biological Process	GO:0006986	response to unfolded protein	Hspa1a	IMP		Rat	PMID:8271311\|RGD:1298961
Biological Process	GO:0009410	response to xenobiotic stimulus	hsp70.1	IDA		Zfish	PMID:17497411
Biological Process	GO:0009410	response to xenobiotic stimulus	hsp70.1	IDA		Zfish	PMID:18973944

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.