Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HSPA2
  • Mouse genes Hspa2
  • Rat genes Hspa2
  • Zfish genes hsp70.1,hsp70.2,hsp70.3,hsp70l,hspa1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hspa2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0097718	disordered domain specific binding	HSPA2	IPI	UniProtKB:Q89933	Human	PMID:15914229
Molecular Function	GO:0019899	enzyme binding	HSPA2	IPI	UniProtKB:Q8WXB1	Human	PMID:23921388
Molecular Function	GO:0051861	glycolipid binding	Hspa2	IDA		Mouse	PMID:9337084
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q9NZL4	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q9NZL4	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:O95429	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q96BE0	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:O00635	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q9NZL4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q9NZL4	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:O00635	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:O95429	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:A0A024RCP2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:O14544	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:O15534	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:O60506-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:O60636	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:P05455	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:P15407	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:P30301	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:P49459	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:P79522	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q06547-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q06547-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q0VD86	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q13562	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q14181	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q15973	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q3KNS6-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q496A3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q53R41	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q58EX7-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q5SXH7-1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q66PJ3-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q6DHV7-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q6GQQ9-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q6P597	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q7Z6I5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q7Z7C8-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q8N0U2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q8N2H9-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q8N5Z5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q8TBE0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q8WUU4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q8WUX9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q92530	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q92615	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q92782-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q96DX5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q96EY1-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q96FT7-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q96MA6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q99683	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q9BRR0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q9BYN7-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q9H1D9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q9HD47-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q9NNX6-10	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q9NSA1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q9NUC0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q9NX94	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q9UBL3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q9UHI5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HSPA2	IPI	UniProtKB:Q9Y4F5-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Hspa2	IPI	UniProtKB:Q9Z1R2	Mouse	MGI:MGI:3808636|PMID:18678708
Molecular Function	GO:0005515	protein binding	Hspa2	IPI	UniProtKB:Q3TTP0	Mouse	MGI:MGI:5705213|PMID:24557841
Molecular Function	GO:0005515	protein binding	Hspa2	IPI	UniProtKB:Q99MV5	Mouse	MGI:MGI:4457263|PMID:20547853
Molecular Function	GO:0005515	protein binding	Hspa2	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0005515	protein binding	Hspa2	IPI	PR:Q91ZR5	Mouse	PMID:17478420
Molecular Function	GO:0005515	protein binding	Hspa2	IPI	PR:P11440	Mouse	PMID:9247342
Molecular Function	GO:0005515	protein binding	Hspa2	IPI	PR:O35723	Mouse	PMID:11466217
Molecular Function	GO:0005515	protein binding	Hspa2	IPI	RGD:71058	Rat	PMID:16518874|RGD:10054427
Molecular Function	GO:0051087	protein-folding chaperone binding	Hspa2	IPI	UniProtKB:Q91YN9	Rat	PMID:19228967|RGD:13514075
Molecular Function	GO:0048156	tau protein binding	Hspa2	IPI	UniProtKB:P19332	Rat	PMID:19228967|RGD:13514075
Molecular Function	GO:0051082	unfolded protein binding	HSPA2	IDA		Human	PMID:21231916
Cellular Component	GO:0072562	blood microparticle	HSPA2	HDA		Human	PMID:22516433
Cellular Component	GO:0036128	CatSper complex	Hspa2	IDA		Mouse	MGI:MGI:5315675|PMID:21224844
Cellular Component	GO:0009986	cell surface	Hspa2	IDA		Mouse	PMID:9337084
Cellular Component	GO:0005829	cytosol	HSPA2	IDA		Human	PMID:21231916
Cellular Component	GO:0070062	extracellular exosome	HSPA2	HDA		Human	PMID:19056867
Cellular Component	GO:0001673	male germ cell nucleus	Hspa2	IDA		Mouse	PMID:17035236
Cellular Component	GO:0072687	meiotic spindle	Hspa2	IDA		Mouse	MGI:MGI:5705213|PMID:24557841
Cellular Component	GO:0016020	membrane	HSPA2	HDA		Human	PMID:19946888
Cellular Component	GO:0005739	mitochondrion	Hspa2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0043209	myelin sheath	Hspa2	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005634	nucleus	HSPA2	HDA		Human	PMID:21630459
Cellular Component	GO:0000795	synaptonemal complex	Hspa2	IDA		Mouse	PMID:8622925
Biological Process	GO:0001568	blood vessel development	hsp70l	IMP	ZFIN:ZDB-MRPHLNO-121213-3	Zfish	PMID:23139789
Biological Process	GO:0048593	camera-type eye morphogenesis	hsp70.3	IMP	ZFIN:ZDB-MRPHLNO-050726-2	Zfish	PMID:15832949
Biological Process	GO:0048593	camera-type eye morphogenesis	hsp70.1	IMP	ZFIN:ZDB-MRPHLNO-050726-1	Zfish	PMID:15832949
Biological Process	GO:0060216	definitive hemopoiesis	hsp70l	IMP	ZFIN:ZDB-MRPHLNO-121213-3	Zfish	PMID:24787902
Biological Process	GO:0060216	definitive hemopoiesis	hsp70l	IGI	ZFIN:ZDB-MRPHLNO-121213-3,ZFIN:ZDB-MRPHLNO-160211-6	Zfish	PMID:24787902
Biological Process	GO:0007141	male meiosis I	Hspa2	IMP	MGI:MGI:2447605	Mouse	PMID:9409676
Biological Process	GO:0007140	male meiotic nuclear division	Hspa2	IMP	MGI:MGI:2447605	Mouse	PMID:8622925
Biological Process	GO:0090084	negative regulation of inclusion body assembly	HSPA2	IDA		Human	PMID:21231916
Biological Process	GO:0032781	positive regulation of ATP-dependent activity	Hspa2	IMP		Mouse	MGI:MGI:5319411|PMID:22495301
Biological Process	GO:1901896	positive regulation of ATPase-coupled calcium transmembrane transporter activity	Hspa2	IMP		Mouse	MGI:MGI:5319411|PMID:22495301
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	Hspa2	IMP	MGI:MGI:2447605	Mouse	PMID:9247342
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Hspa2	IMP	MGI:MGI:2447605	Mouse	PMID:9247342
Biological Process	GO:0042026	protein refolding	HSPA2	IDA		Human	PMID:21231916
Biological Process	GO:0046686	response to cadmium ion	hsp70l	IDA		Zfish	PMID:17706735
Biological Process	GO:0046686	response to cadmium ion	hsp70.1	IEP		Zfish	PMID:16799861
Biological Process	GO:0009408	response to heat	hsp70l	IDA		Zfish	PMID:10751183
Biological Process	GO:0009408	response to heat	hsp70.1	IDA		Zfish	PMID:10751183
Biological Process	GO:0010038	response to metal ion	hsp70l	IDA		Zfish	PMID:26354112
Biological Process	GO:0009410	response to xenobiotic stimulus	hsp70.1	IDA		Zfish	PMID:17497411
Biological Process	GO:0009410	response to xenobiotic stimulus	hsp70.1	IDA		Zfish	PMID:18973944
Biological Process	GO:0007286	spermatid development	Hspa2	IMP	MGI:MGI:2447605	Mouse	PMID:8622925
Biological Process	GO:0007283	spermatogenesis	Hspa2	IMP		Mouse	MGI:MGI:5705213|PMID:24557841
Biological Process	GO:0070194	synaptonemal complex disassembly	Hspa2	IMP	MGI:MGI:2447605	Mouse	PMID:9409676

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern