Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HSPA4
  • Mouse genes Hspa4
  • Rat genes Hspa4
  • Zfish genes hspa4a,hspa4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hspa4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	HSPA4	IPI	UniProtKB:P00533	Human	PMID:20029029
Molecular Function	GO:0005515	protein binding	HSPA4	IPI	UniProtKB:P11142	Human	PMID:22990239
Molecular Function	GO:0005515	protein binding	HSPA4	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	HSPA4	IPI	UniProtKB:Q6RW13	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HSPA4	IPI	UniProtKB:Q92624	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HSPA4	IPI	UniProtKB:P11142	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	HSPA4	IPI	UniProtKB:P11142	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	HSPA4	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	HSPA4	IPI	UniProtKB:P78424	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HSPA4	IPI	UniProtKB:Q92624	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Hspa4	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0005515	protein binding	Hspa4	IPI	RGD:10975	Rat	PMID:17473852|RGD:5688754
Molecular Function	GO:0005515	protein binding	Hspa4	IPI	RGD:620575	Rat	PMID:22143029|RGD:5686888
Molecular Function	GO:0044877	protein-containing complex binding	Hspa4	IPI	RGD:2192,RGD:1307794	Rat	PMID:21561597|RGD:5687132
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Hspa4	IPI	RGD:1551095	Rat	PMID:17473852|RGD:5688754
Cellular Component	GO:0005737	cytoplasm	Hspa4	IDA		Rat	PMID:21861342|RGD:5686908
Cellular Component	GO:0005829	cytosol	HSPA4	IDA		Human	PMID:21231916
Cellular Component	GO:0005829	cytosol	Hspa4	IDA		Rat	PMID:11415446|RGD:4892111
Cellular Component	GO:0005829	cytosol	Hspa4	IDA		Rat	PMID:17175194|RGD:4892095
Cellular Component	GO:0070062	extracellular exosome	HSPA4	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	HSPA4	IDA		Human	PMID:21276792
Cellular Component	GO:0005811	lipid droplet	Hspa4	IDA		Rat	PMID:17175194|RGD:4892095
Cellular Component	GO:0005634	nucleus	Hspa4	IDA		Rat	PMID:21861342|RGD:5686908
Biological Process	GO:0051131	chaperone-mediated protein complex assembly	HSPA4	IDA		Human	PMID:15644312
Biological Process	GO:0001822	kidney development	Hspa4	IEP		Rat	PMID:21938673|RGD:5686902
Biological Process	GO:0043066	negative regulation of apoptotic process	Hspa4	IEP		Rat	PMID:21857080|RGD:5686907
Biological Process	GO:0043392	negative regulation of DNA binding	Hspa4	IMP		Rat	PMID:17473852|RGD:5688754
Biological Process	GO:0010629	negative regulation of gene expression	Hspa4	IMP		Rat	PMID:17473852|RGD:5688754
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Hspa4	IMP		Rat	PMID:17473852|RGD:5688754
Biological Process	GO:0051402	neuron apoptotic process	Hspa4	IMP		Rat	PMID:17473852|RGD:5688754
Biological Process	GO:0045766	positive regulation of angiogenesis	Hspa4	IEP		Rat	PMID:22098710|RGD:5686892
Biological Process	GO:0032092	positive regulation of protein binding	Hspa4	IDA		Rat	PMID:11415446|RGD:4892111
Biological Process	GO:0045040	protein insertion into mitochondrial outer membrane	HSPA4	IDA		Human	PMID:15644312
Biological Process	GO:1903978	regulation of microglial cell activation	Hspa4	IMP		Rat	PMID:17473852|RGD:5688754
Biological Process	GO:0009408	response to heat	Hspa4	IDA		Rat	PMID:10098860|RGD:633150

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern