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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hspa5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hspa5
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0005524ATP bindingHSPA5IDAHumanPMID:26655470
Molecular FunctionGO:0016887ATP hydrolysis activityHSPA5IDAHumanPMID:20335166
Molecular FunctionGO:0016887ATP hydrolysis activityHSPA5IDAHumanPMID:23975754
Molecular FunctionGO:0045296cadherin bindingHSPA5HDAHumanPMID:25468996
Molecular FunctionGO:0019899enzyme bindingHSPA5IPIUniProtKB:Q8WXB1HumanPMID:23921388
Molecular FunctionGO:0051787misfolded protein bindingHSPA5IDAHumanPMID:18400946
Molecular FunctionGO:0051787misfolded protein bindingHspa5IDAMouseMGI:MGI:4418606|PMID:18923430
Molecular FunctionGO:0051787misfolded protein bindingHspa5IDARatPMID:23444373|RGD:8554667
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9NZJ5HumanPMID:11907036
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9H173HumanPMID:12356756
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:P62993HumanPMID:12577067
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q13573HumanPMID:12840015
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:P04049HumanPMID:18064632
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q96DZ1HumanPMID:18264092
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q13438HumanPMID:18502753
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q86TM6HumanPMID:18502753
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q96DZ1-1HumanPMID:18502753
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9UBV2HumanPMID:18502753
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9UBS4HumanPMID:18923428
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q91YW3HumanPMID:18923430
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q62627HumanPMID:19632185
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q96IZ0HumanPMID:19632185
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9UBS4HumanPMID:20335166
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q13573HumanPMID:20467437
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q12907HumanPMID:20477988
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:P62993HumanPMID:20936779
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q6T424HumanPMID:22613557
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:P10909HumanPMID:22689054
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q6E0U4HumanPMID:22735594
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:P61619HumanPMID:22796945
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:O95994HumanPMID:23220234
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q86XA0HumanPMID:23349634
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q8IXB1HumanPMID:23769672
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q8WUJ3HumanPMID:23990668
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:P04626HumanPMID:24189400
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q15084HumanPMID:24189400
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9UBS4HumanPMID:24189400
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9H173HumanPMID:24473200
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9BVA6HumanPMID:25601083
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:P14625HumanPMID:26496610
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9Y4L1HumanPMID:26496610
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:O75460-1HumanPMID:26551274
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:O75460HumanPMID:27238082
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:P18850HumanPMID:27238082
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9NZJ5HumanPMID:27238082
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9H173HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9UBS4HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9QXT0HumanPMID:28869608
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9Z2B5HumanPMID:28869608
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:K0BRG7HumanPMID:29887526
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:P14625HumanPMID:30021884
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q15084HumanPMID:30021884
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9Y4L1HumanPMID:30021884
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9H173HumanPMID:31258504
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:P04626HumanPMID:31980649
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:P62993HumanPMID:31980649
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:P05067HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q13404HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q13573HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q15486HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q6PF05HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9UHI5HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9ULD4-2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:P0DTC2HumanPMID:33965375
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9BYF1HumanPMID:33965375
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:P0DTC2HumanPMID:34615619
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:Q9BYF1HumanPMID:34615619
Molecular FunctionGO:0005515protein bindingHSPA5IPIUniProtKB:P04626HumanPMID:35384245
Molecular FunctionGO:0005515protein bindingHspa5IPIUniProtKB:O35451|UniProtKB:P00441MouseMGI:MGI:3623653|PMID:16595634
Molecular FunctionGO:0005515protein bindingHspa5IPIUniProtKB:Q91YW3MouseMGI:MGI:4418606|PMID:18923430
Molecular FunctionGO:0005515protein bindingHspa5IPIUniProtKB:Q9QYI6MouseMGI:MGI:2179172|PMID:11836248
Molecular FunctionGO:0005515protein bindingHspa5IPIUniProtKB:P00441MouseMGI:MGI:3831018|PMID:19171884
Molecular FunctionGO:0005515protein bindingHspa5IPIUniProtKB:O75460MouseMGI:MGI:3623708|PMID:16645094
Molecular FunctionGO:0005515protein bindingHspa5IPIUniProtKB:Q9D024MouseMGI:MGI:5605216|PMID:25009997
Molecular FunctionGO:0005515protein bindingHspa5IPIUniProtKB:B5TVM2MouseMGI:MGI:6707347|PMID:33863978
Molecular FunctionGO:0005515protein bindingHspa5IPIUniProtKB:Q99KV1MouseMGI:MGI:5926003|PMID:21217698
Molecular FunctionGO:0005515protein bindingHspa5IPIUniProtKB:Q80WW9MouseMGI:MGI:5613470|PMID:21494687
Molecular FunctionGO:0005515protein bindingHspa5IPIUniProtKB:Q91X17MousePMID:28437467
Molecular FunctionGO:0005515protein bindingHspa5IPIPR:O54998MousePMID:14960307
Molecular FunctionGO:0005515protein bindingHspa5IPIPR:Q8K3X6MousePMID:22589549
Molecular FunctionGO:0005515protein bindingHspa5IPIPR:Q7TMF5MousePMID:22837305
Molecular FunctionGO:0005515protein bindingHspa5IPIPR:Q61712MousePMID:12065409
Molecular FunctionGO:0005515protein bindingHspa5IPIPR:P51865MousePMID:17991893
Molecular FunctionGO:0005515protein bindingHspa5IPIPR:E9Q9D5MousePMID:23055941
Molecular FunctionGO:0005515protein bindingHspa5IPIRGD:727936RatPMID:12514190|RGD:1299605
Molecular FunctionGO:0005515protein bindingHspa5IPIUniProtKB:Q9R0C9RatPMID:17981125|RGD:8554014
Molecular FunctionGO:0005515protein bindingHspa5IPIRGD:2508RatPMID:18757373|RGD:11354920
Molecular FunctionGO:0005515protein bindingHspa5IPIUniProtKB:P06882RatPMID:7916014|RGD:8554190
Molecular FunctionGO:0005515protein bindingHspa5IPIUniProtKB:P52555RatPMID:9714535|RGD:10047223
Molecular FunctionGO:0019904protein domain specific bindingHSPA5IPIUniProtKB:Q8IXB1HumanPMID:12411443
Molecular FunctionGO:0044183protein folding chaperoneHspa5IDAMousePMID:23123197
Molecular FunctionGO:0043022ribosome bindingHspa5IDAMousePMID:12065409
Molecular FunctionGO:0031625ubiquitin protein ligase bindingHSPA5IPIUniProtKB:P19474HumanPMID:8666824
Molecular FunctionGO:0051082unfolded protein bindingHspa5IPIRGD:3848RatPMID:11884402|RGD:728752
Cellular ComponentGO:0009986cell surfaceHspa5IDAMousePMID:17991893
Cellular ComponentGO:0005737cytoplasmHSPA5IDAHumanPMID:22689054
Cellular ComponentGO:0005737cytoplasmHspa5IDARatPMID:24129401|RGD:11354962
Cellular ComponentGO:0005829cytosolHSPA5IDAHumanPMID:22689054
Cellular ComponentGO:0005783endoplasmic reticulumHSPA5IMPHumanPMID:11943137
Cellular ComponentGO:0005783endoplasmic reticulumHSPA5IDAHumanPMID:16223484
Cellular ComponentGO:0005783endoplasmic reticulumHspa5IDAMouseMGI:MGI:5613470|PMID:21494687
Cellular ComponentGO:0005783endoplasmic reticulumHspa5IDAMousePMID:15294975
Cellular ComponentGO:0005783endoplasmic reticulumHspa5IDAMousePMID:22783020
Cellular ComponentGO:0005783endoplasmic reticulumHspa5IDAMousePMID:26438849
Cellular ComponentGO:0005783endoplasmic reticulumHspa5IDAMousePMID:19359471
Cellular ComponentGO:0005783endoplasmic reticulumHspa5IDAMousePMID:7679955
Cellular ComponentGO:0005783endoplasmic reticulumHspa5IDAMousePMID:14960307
Cellular ComponentGO:0005783endoplasmic reticulumHspa5IDAMousePMID:16906134
Cellular ComponentGO:0005783endoplasmic reticulumHspa5IDAMousePMID:12646573
Cellular ComponentGO:0005783endoplasmic reticulumHspa5IDAMousePMID:23926254
Cellular ComponentGO:0005783endoplasmic reticulumHspa5IDAMousePMID:12826667
Cellular ComponentGO:0005783endoplasmic reticulumHspa5IDAMousePMID:23913443
Cellular ComponentGO:0005783endoplasmic reticulumHspa5IDAMousePMID:26582200
Cellular ComponentGO:0005783endoplasmic reticulumHspa5IDAMousePMID:15452145
Cellular ComponentGO:0005783endoplasmic reticulumHspa5IDARatPMID:19474315|RGD:8554250
Cellular ComponentGO:0034663endoplasmic reticulum chaperone complexHSPA5IDAHumanPMID:18400946
Cellular ComponentGO:0034663endoplasmic reticulum chaperone complexHspa5IDAMouseMGI:MGI:5613481|PMID:12475965
Cellular ComponentGO:0005788endoplasmic reticulum lumenHSPA5IDAHumanPMID:21289099
Cellular ComponentGO:0005788endoplasmic reticulum lumenHspa5IDAMouseMGI:MGI:4437543|PMID:19816510
Cellular ComponentGO:0005789endoplasmic reticulum membraneHSPA5IDAHumanPMID:11181571
Cellular ComponentGO:0005789endoplasmic reticulum membraneHspa5IDAMousePMID:22589549
Cellular ComponentGO:0005793endoplasmic reticulum-Golgi intermediate compartmentHSPA5IDAHumanPMID:15308636
Cellular ComponentGO:0005793endoplasmic reticulum-Golgi intermediate compartmentHspa5IDAMousePMID:21187406
Cellular ComponentGO:0070062extracellular exosomeHSPA5HDAHumanPMID:19056867
Cellular ComponentGO:0070062extracellular exosomeHSPA5HDAHumanPMID:19199708
Cellular ComponentGO:0070062extracellular exosomeHSPA5HDAHumanPMID:20458337
Cellular ComponentGO:0005576extracellular regionhspa5IDAZfishPMID:11748832
Cellular ComponentGO:0005925focal adhesionHSPA5HDAHumanPMID:21423176
Cellular ComponentGO:0043231intracellular membrane-bounded organelleHSPA5IDAHumanPMID:22689054
Cellular ComponentGO:0016020membraneHSPA5HDAHumanPMID:19946888
Cellular ComponentGO:0016020membraneHspa5IDARatPMID:23444373|RGD:8554667
Cellular ComponentGO:0030496midbodyHSPA5IDAHumanPMID:15166316
Cellular ComponentGO:0005739mitochondrionHSPA5IDAHumanPMID:22689054
Cellular ComponentGO:0005739mitochondrionHspa5IDARatPMID:20533907|RGD:7327223
Cellular ComponentGO:0043209myelin sheathHspa5HDAMouseMGI:MGI:3834050|PMID:17634366
Cellular ComponentGO:0005634nucleusHSPA5IMPHumanPMID:11943137
Cellular ComponentGO:0005634nucleusHSPA5HDAHumanPMID:21630459
Cellular ComponentGO:0005886plasma membraneHspa5IDAMousePMID:22837305
Cellular ComponentGO:0032991protein-containing complexHSPA5IDAHumanPMID:23349634
Cellular ComponentGO:0005790smooth endoplasmic reticulumHspa5IDARatPMID:22665516|RGD:8553430
Biological ProcessGO:0071236cellular response to antibioticHspa5IEPRatPMID:19332540|RGD:7242708
Biological ProcessGO:0071277cellular response to calcium ionHspa5IEPRatPMID:9058202|RGD:11354978
Biological ProcessGO:0071320cellular response to cAMPHspa5IEPRatPMID:9058202|RGD:11354978
Biological ProcessGO:0071480cellular response to gamma radiationHspa5IEPRatPMID:20470193|RGD:11354917
Biological ProcessGO:0042149cellular response to glucose starvationHSPA5IDAHumanPMID:10085239
Biological ProcessGO:0071353cellular response to interleukin-4Hspa5IDAMousePMID:9798653
Biological ProcessGO:0071287cellular response to manganese ionHspa5IEPRatPMID:23934647|RGD:10047151
Biological ProcessGO:1990090cellular response to nerve growth factor stimulusHspa5IEPRatPMID:10936191|RGD:11354963
Biological ProcessGO:0071466cellular response to xenobiotic stimulusHspa5IEPRatPMID:18757512|RGD:11354916
Biological ProcessGO:0021680cerebellar Purkinje cell layer developmentHspa5IMPMouseMGI:MGI:4437543|PMID:19816510
Biological ProcessGO:0021589cerebellum structural organizationHspa5IMPMouseMGI:MGI:4437543|PMID:19816510
Biological ProcessGO:0030968endoplasmic reticulum unfolded protein responseHspa5IMPMouseMGI:MGI:4437543|PMID:19816510
Biological ProcessGO:0006983ER overload responseHspa5IDAMousePMID:11854325
Biological ProcessGO:0036498IRE1-mediated unfolded protein responseHspa5IEPMousePMID:24508390
Biological ProcessGO:0001554luteolysisHspa5IEPRatPMID:25332219|RGD:13782179
Biological ProcessGO:0035437maintenance of protein localization in endoplasmic reticulumHSPA5IMPHumanPMID:23990668
Biological ProcessGO:0043066negative regulation of apoptotic processHSPA5IMPHumanPMID:10760948
Biological ProcessGO:0043066negative regulation of apoptotic processHSPA5IMPHumanPMID:12665508
Biological ProcessGO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayHspa5IGIMGI:MGI:98658MousePMID:17991893
Biological ProcessGO:0051402neuron apoptotic processHspa5IEPRatPMID:9058202|RGD:11354978
Biological ProcessGO:0030182neuron differentiationHspa5IEPRatPMID:19322020|RGD:11354958
Biological ProcessGO:0030335positive regulation of cell migrationHSPA5IMPHumanPMID:23990668
Biological ProcessGO:0010976positive regulation of neuron projection developmentHspa5IMPRatPMID:10936191|RGD:11354963
Biological ProcessGO:0031398positive regulation of protein ubiquitinationHspa5IMPMouseMGI:MGI:4437543|PMID:19816510
Biological ProcessGO:0031204post-translational protein targeting to membrane, translocationHSPA5IMPHumanPMID:29719251
Biological ProcessGO:0051603proteolysis involved in protein catabolic processHspa5IDAMouseMGI:MGI:4418606|PMID:18923430
Biological ProcessGO:0042220response to cocaineHspa5IEPRatPMID:17849098|RGD:2311462
Biological ProcessGO:0034976response to endoplasmic reticulum stressHspa5IDARatPMID:23444373|RGD:8554667
Biological ProcessGO:0034976response to endoplasmic reticulum stressHspa5IEPRatPMID:22189689|RGD:11354954
Biological ProcessGO:0001666response to hypoxiahspa5IDAZfishPMID:25814654
Biological ProcessGO:1904313response to methamphetamine hydrochlorideHspa5IEPRatPMID:19826936|RGD:11354955
Biological ProcessGO:0009314response to radiationHspa5IEPRatPMID:25632565|RGD:11354959
Biological ProcessGO:0001878response to yeasthspa5IDAZfishPMID:23947337
Biological ProcessGO:0097501stress response to metal ionHspa5IEPRatPMID:17915553|RGD:11354918
Biological ProcessGO:0021762substantia nigra developmentHSPA5HEPHumanPMID:22926577
Biological ProcessGO:1901998toxin transportHspa5IMPMousePMID:23716698

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory