Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hspg2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HSPG2
- Mouse genes Hspg2
- Rat genes Hspg2
- Zfish genes hspg2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hspg2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070052	collagen V binding	Hspg2	IPI	RGD:70922	Rat	PMID:15383532\|RGD:5683638
Molecular Function	GO:0002020	protease binding	Hspg2	IPI	UniProtKB:P07711\|UniProtKB:P07858\|UniProtKB:P25774\|UniProtKB:P43235	Mouse	MGI:MGI:5553237\|PMID:22952693
Molecular Function	GO:0005515	protein binding	HSPG2	IPI	UniProtKB:Q5TAT6	Human	PMID:11956183
Molecular Function	GO:0005515	protein binding	HSPG2	IPI	UniProtKB:Q16610	Human	PMID:12604605
Molecular Function	GO:0005515	protein binding	HSPG2	IPI	UniProtKB:P35968	Human	PMID:21596751
Molecular Function	GO:0005515	protein binding	HSPG2	IPI	UniProtKB:P35968	Human	PMID:23374253
Molecular Function	GO:0005515	protein binding	Hspg2	IPI	UniProtKB:P14543	Mouse	MGI:MGI:5553237\|PMID:22952693
Molecular Function	GO:0005515	protein binding	Hspg2	IPI	PR:O88322	Mouse	PMID:12243745
Molecular Function	GO:0005515	protein binding	Hspg2	IPI	PR:Q8R2Z5	Mouse	PMID:16407285
Cellular Component	GO:0005604	basement membrane	Hspg2	IDA		Mouse	PMID:18757743
Cellular Component	GO:0005604	basement membrane	Hspg2	IDA		Mouse	PMID:15928325
Cellular Component	GO:0005604	basement membrane	Hspg2	IDA		Mouse	PMID:10352025
Cellular Component	GO:0005604	basement membrane	Hspg2	IDA		Mouse	PMID:15895400
Cellular Component	GO:0005604	basement membrane	Hspg2	IDA		Mouse	PMID:10579729
Cellular Component	GO:0005604	basement membrane	Hspg2	IDA		Mouse	PMID:12588956
Cellular Component	GO:0005604	basement membrane	Hspg2	IDA		Mouse	PMID:11787818
Cellular Component	GO:0005604	basement membrane	Hspg2	IDA		Mouse	PMID:7670489
Cellular Component	GO:0005604	basement membrane	Hspg2	IDA		Mouse	PMID:15381701
Cellular Component	GO:0005604	basement membrane	Hspg2	IDA		Mouse	PMID:11802174
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HSPG2	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HSPG2	HDA		Human	PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HSPG2	HDA		Human	PMID:23979707
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HSPG2	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HSPG2	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HSPG2	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HSPG2	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Hspg2	HDA		Mouse	MGI:MGI:6201834\|PMID:22159717
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Hspg2	HDA		Mouse	MGI:MGI:6201853\|PMID:28071719
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Hspg2	HDA		Mouse	MGI:MGI:5582867\|PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Hspg2	IDA		Rat	PMID:15928048\|RGD:1624263
Cellular Component	GO:0070062	extracellular exosome	HSPG2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	HSPG2	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	HSPG2	HDA		Human	PMID:21362503
Cellular Component	GO:0070062	extracellular exosome	HSPG2	HDA		Human	PMID:23533145
Cellular Component	GO:0031012	extracellular matrix	Hspg2	IDA		Mouse	PMID:15381701
Cellular Component	GO:0031012	extracellular matrix	Hspg2	IDA		Mouse	PMID:10579729
Cellular Component	GO:0031012	extracellular matrix	Hspg2	IDA		Mouse	PMID:16407285
Cellular Component	GO:0031012	extracellular matrix	Hspg2	IDA		Mouse	PMID:23217742
Cellular Component	GO:0005576	extracellular region	HSPG2	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	HSPG2	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	HSPG2	HDA		Human	PMID:20551380
Cellular Component	GO:0005925	focal adhesion	HSPG2	HDA		Human	PMID:21423176
Biological Process	GO:0001525	angiogenesis	hspg2	IMP	ZFIN:ZDB-MRPHLNO-080807-1	Zfish	PMID:19422911
Biological Process	GO:0001525	angiogenesis	hspg2	IMP	ZFIN:ZDB-MRPHLNO-080807-1	Zfish	PMID:18426981
Biological Process	GO:0001525	angiogenesis	hspg2	IMP	ZFIN:ZDB-MRPHLNO-080807-3	Zfish	PMID:18426981
Biological Process	GO:0031100	animal organ regeneration	Hspg2	IEP		Rat	PMID:8941340\|RGD:1624266
Biological Process	GO:0043534	blood vessel endothelial cell migration	hspg2	IMP	ZFIN:ZDB-MRPHLNO-080807-1	Zfish	PMID:19422911
Biological Process	GO:0007420	brain development	Hspg2	IMP	MGI:MGI:1934892	Mouse	PMID:10579729
Biological Process	GO:0048738	cardiac muscle tissue development	Hspg2	IMP	MGI:MGI:1934892	Mouse	PMID:10579729
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	Hspg2	IMP	MGI:MGI:1934891	Mouse	PMID:10545953
Biological Process	GO:0002062	chondrocyte differentiation	Hspg2	IMP	MGI:MGI:1934891	Mouse	PMID:10545953
Biological Process	GO:0007566	embryo implantation	Hspg2	IEP		Rat	PMID:10372552\|RGD:1624264
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Hspg2	IMP	MGI:MGI:1934892	Mouse	PMID:10579729
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	hspg2	IMP	ZFIN:ZDB-MRPHLNO-211110-1	Zfish	PMID:33678174
Biological Process	GO:0001958	endochondral ossification	Hspg2	IMP	MGI:MGI:1934892	Mouse	PMID:10579729
Biological Process	GO:0001935	endothelial cell proliferation	hspg2	IMP	ZFIN:ZDB-MRPHLNO-080807-1	Zfish	PMID:19422911
Biological Process	GO:0030198	extracellular matrix organization	Hspg2	IMP	MGI:MGI:1934892	Mouse	PMID:10579729
Biological Process	GO:0007162	negative regulation of cell adhesion	Hspg2	IDA		Rat	PMID:11382923\|RGD:1624256
Biological Process	GO:0008285	negative regulation of cell population proliferation	Hspg2	IDA		Rat	PMID:14656929\|RGD:1358424
Biological Process	GO:0014033	neural crest cell differentiation	hspg2	IMP	ZFIN:ZDB-MRPHLNO-211110-1	Zfish	PMID:33678174
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	Hspg2	IMP		Rat	PMID:17437047\|RGD:1624260
Biological Process	GO:0008104	protein localization	Hspg2	IMP	MGI:MGI:1934891	Mouse	PMID:11802174
Biological Process	GO:0006898	receptor-mediated endocytosis	Hspg2	IGI	UniProtKB:A0A0R4J0I9	Mouse	MGI:MGI:5897551\|PMID:21289173
Biological Process	GO:0006898	receptor-mediated endocytosis	Hspg2	IMP		Mouse	MGI:MGI:5897551\|PMID:21289173
Biological Process	GO:0001666	response to hypoxia	Hspg2	IEP		Rat	PMID:17437047\|RGD:1624260
Biological Process	GO:0009410	response to xenobiotic stimulus	Hspg2	IEP		Rat	PMID:16771604\|RGD:1624262
Biological Process	GO:0007519	skeletal muscle tissue development	hspg2	IMP	ZFIN:ZDB-MRPHLNO-080807-3	Zfish	PMID:18426981
Biological Process	GO:0007519	skeletal muscle tissue development	hspg2	IMP	ZFIN:ZDB-MRPHLNO-080807-1	Zfish	PMID:18426981
Biological Process	GO:0007519	skeletal muscle tissue development	hspg2	IMP	ZFIN:ZDB-MRPHLNO-080807-2	Zfish	PMID:18426981
Biological Process	GO:0007224	smoothened signaling pathway	Hspg2	IDA		Rat	PMID:21720682\|RGD:5510033

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.