Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Htr2c

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HTR2C
- Mouse genes Htr2c
- Rat genes Htr2c
- Zfish genes htr2cl1,htr2cl2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Htr2c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	HTR2C	IDA		Human	PMID:19057895
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	HTR2C	IDA		Human	PMID:12970106
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	HTR2C	IDA		Human	PMID:7582481
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr2c	IMP		Mouse	MGI:MGI:5140621\|PMID:21835345
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr2c	IMP		Rat	PMID:15663485\|RGD:1358734
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr2c	IDA		Rat	PMID:8626447\|RGD:8554296
Molecular Function	GO:0001587	Gq/11-coupled serotonin receptor activity	HTR2C	IDA		Human	PMID:18703043
Molecular Function	GO:0042802	identical protein binding	HTR2C	IPI	UniProtKB:P28335	Human	PMID:15518545
Molecular Function	GO:0042802	identical protein binding	HTR2C	IPI	UniProtKB:P28335	Human	PMID:16195233
Molecular Function	GO:0042802	identical protein binding	HTR2C	IPI	UniProtKB:P28335	Human	PMID:25770211
Molecular Function	GO:0042802	identical protein binding	HTR2C	IPI	UniProtKB:P28335	Human	PMID:28258217
Molecular Function	GO:0005515	protein binding	HTR2C	IPI	UniProtKB:O88910	Human	PMID:14988405
Molecular Function	GO:0005515	protein binding	HTR2C	IPI	UniProtKB:P49286	Human	PMID:25770211
Molecular Function	GO:0005515	protein binding	HTR2C	IPI	UniProtKB:P28223	Human	PMID:28258217
Molecular Function	GO:0005515	protein binding	HTR2C	IPI	UniProtKB:P41595	Human	PMID:28258217
Molecular Function	GO:0005515	protein binding	HTR2C	IPI	UniProtKB:Q9BVK8	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	HTR2C	IPI	UniProtKB:P28223	Human	PMID:30157263
Molecular Function	GO:0005515	protein binding	HTR2C	IPI	UniProtKB:O95406	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HTR2C	IPI	UniProtKB:P54849	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HTR2C	IPI	UniProtKB:P55061	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HTR2C	IPI	UniProtKB:Q9BVK8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HTR2C	IPI	UniProtKB:Q9NUM3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Htr2c	IPI	UniProtKB:O88910	Mouse	MGI:MGI:3698112\|PMID:16914526
Molecular Function	GO:0005515	protein binding	Htr2c	IPI	RGD:61995	Rat	PMID:16474401\|RGD:2292548
Molecular Function	GO:0051378	serotonin binding	HTR2C	IDA		Human	PMID:12970106
Molecular Function	GO:0051378	serotonin binding	HTR2C	IDA		Human	PMID:15831837
Molecular Function	GO:0051378	serotonin binding	HTR2C	IDA		Human	PMID:18703043
Molecular Function	GO:0051378	serotonin binding	HTR2C	IDA		Human	PMID:19057895
Molecular Function	GO:0051378	serotonin binding	HTR2C	IDA		Human	PMID:7582481
Cellular Component	GO:0009986	cell surface	Htr2c	IDA		Rat	PMID:15663485\|RGD:1358734
Cellular Component	GO:0009897	external side of plasma membrane	Htr2c	IDA		Rat	PMID:1373499\|RGD:8554181
Cellular Component	GO:0098666	G protein-coupled serotonin receptor complex	HTR2C	IDA		Human	PMID:12970106
Cellular Component	GO:0098666	G protein-coupled serotonin receptor complex	HTR2C	IDA		Human	PMID:18703043
Cellular Component	GO:0005886	plasma membrane	HTR2C	IDA		Human	PMID:12970106
Cellular Component	GO:0005886	plasma membrane	HTR2C	IDA		Human	PMID:18703043
Cellular Component	GO:0005886	plasma membrane	HTR2C	IMP		Human	PMID:18703043
Biological Process	GO:0031100	animal organ regeneration	Htr2c	IEP		Rat	PMID:17258772\|RGD:1624998
Biological Process	GO:0001662	behavioral fear response	Htr2c	IMP		Mouse	MGI:MGI:3798744\|PMID:17451451
Biological Process	GO:0035095	behavioral response to nicotine	Htr2c	IMP		Rat	PMID:17473916\|RGD:1624994
Biological Process	GO:0019934	cGMP-mediated signaling	HTR2C	IDA		Human	PMID:12970106
Biological Process	GO:0007631	feeding behavior	Htr2c	IMP		Mouse	MGI:MGI:72086\|PMID:7700379
Biological Process	GO:0007631	feeding behavior	Htr2c	IMP		Rat	PMID:15705738\|RGD:1625006
Biological Process	GO:0098664	G protein-coupled serotonin receptor signaling pathway	HTR2C	IDA		Human	PMID:18703043
Biological Process	GO:0048016	inositol phosphate-mediated signaling	Htr2c	IDA		Rat	PMID:8626447\|RGD:8554296
Biological Process	GO:0006874	intracellular calcium ion homeostasis	HTR2C	IDA		Human	PMID:19057895
Biological Process	GO:0045963	negative regulation of dopamine metabolic process	Htr2c	IMP		Rat	PMID:17018023\|RGD:1625003
Biological Process	GO:0040013	negative regulation of locomotion	Htr2c	IMP		Rat	PMID:15896731\|RGD:1625005
Biological Process	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	HTR2C	IDA		Human	PMID:12970106
Biological Process	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	Htr2c	IMP		Mouse	MGI:MGI:5140621\|PMID:21835345
Biological Process	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	Htr2c	IDA		Rat	PMID:12435801\|RGD:1598460
Biological Process	GO:0031583	phospholipase D-activating G protein-coupled receptor signaling pathway	Htr2c	IMP		Rat	PMID:12435801\|RGD:1598460
Biological Process	GO:0014057	positive regulation of acetylcholine secretion, neurotransmission	Htr2c	IMP		Rat	PMID:15266551\|RGD:1625007
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	Htr2c	IMP		Mouse	MGI:MGI:5140621\|PMID:21835345
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	HTR2C	IDA		Human	PMID:19057895
Biological Process	GO:0045600	positive regulation of fat cell differentiation	Htr2c	IMP		Mouse	PMID:20719859
Biological Process	GO:0014054	positive regulation of gamma-aminobutyric acid secretion	Htr2c	IMP		Rat	PMID:17043669\|RGD:1625001
Biological Process	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process	HTR2C	IDA		Human	PMID:19057895
Biological Process	GO:0045907	positive regulation of vasoconstriction	Htr2c	IMP		Rat	PMID:15118345\|RGD:1625008
Biological Process	GO:0032098	regulation of appetite	Htr2c	IMP		Mouse	MGI:MGI:4849332\|PMID:21048120
Biological Process	GO:0043397	regulation of corticotropin-releasing hormone secretion	Htr2c	IMP		Mouse	MGI:MGI:3716046\|PMID:17596444
Biological Process	GO:0043397	regulation of corticotropin-releasing hormone secretion	Htr2c	IMP		Mouse	MGI:MGI:3798744\|PMID:17451451
Biological Process	GO:0031644	regulation of nervous system process	Htr2c	IMP		Mouse	MGI:MGI:3716046\|PMID:17596444
Biological Process	GO:0031644	regulation of nervous system process	Htr2c	IMP		Mouse	MGI:MGI:4849332\|PMID:21048120
Biological Process	GO:0051930	regulation of sensory perception of pain	Htr2c	IMP		Rat	PMID:17451674\|RGD:1624996
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	HTR2C	IMP		Human	PMID:18703043
Biological Process	GO:0009410	response to xenobiotic stimulus	Htr2c	IMP		Rat	PMID:16807362\|RGD:1625004

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.