Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HTR3A
  • Mouse genes Htr3a
  • Rat genes Htr3a
  • Zfish genes htr3a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Htr3a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Htr3a	IPI	UniProtKB:P23979-1	Mouse	MGI:MGI:5926256|PMID:26724993
Molecular Function	GO:0042802	identical protein binding	Htr3a	IPI	UniProtKB:P23979-1	Mouse	MGI:MGI:5916607|PMID:25119048
Molecular Function	GO:0042802	identical protein binding	Htr3a	IPI	UniProtKB:P23979-1	Mouse	MGI:MGI:5925455|PMID:20023641
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Htr3a	IDA		Mouse	PMID:25989383
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Htr3a	IMP		Mouse	PMID:25989383
Molecular Function	GO:0005515	protein binding	HTR3A	IPI	UniProtKB:A5X5Y0-1	Human	PMID:17392525
Molecular Function	GO:0005515	protein binding	HTR3A	IPI	UniProtKB:A5X5Y0-3	Human	PMID:17392525
Molecular Function	GO:0005515	protein binding	HTR3A	IPI	UniProtKB:Q70Z44	Human	PMID:17392525
Molecular Function	GO:0005515	protein binding	HTR3A	IPI	UniProtKB:Q8WXA8	Human	PMID:17392525
Molecular Function	GO:0051378	serotonin binding	HTR3A	IDA		Human	PMID:7565620
Molecular Function	GO:0022850	serotonin-gated monoatomic cation-selective channel activity	HTR3A	IDA		Human	PMID:7565620
Molecular Function	GO:0022850	serotonin-gated monoatomic cation-selective channel activity	HTR3A	IDA		Human	PMID:9950429
Molecular Function	GO:0022850	serotonin-gated monoatomic cation-selective channel activity	Htr3a	IDA		Rat	PMID:12196560|RGD:625614
Cellular Component	GO:0030424	axon	Htr3a	IDA		Rat	PMID:17650111|RGD:2316990
Cellular Component	GO:0032154	cleavage furrow	HTR3A	IDA		Human	PMID:19799413
Cellular Component	GO:0005737	cytoplasm	Htr3a	IDA		Rat	PMID:16831594|RGD:2316971
Cellular Component	GO:0098978	glutamatergic synapse	Htr3a	IDA		Rat	PMID:11876772|RGD:13702185
Cellular Component	GO:0043025	neuronal cell body	Htr3a	IDA		Rat	PMID:17650111|RGD:2316990
Cellular Component	GO:0005886	plasma membrane	Htr3a	IDA		Rat	PMID:16831594|RGD:2316971
Cellular Component	GO:0045211	postsynaptic membrane	Htr3a	IDA		Rat	PMID:11876772|RGD:13702185
Cellular Component	GO:0042734	presynaptic membrane	Htr3a	IDA		Rat	PMID:11876772|RGD:13702185
Cellular Component	GO:0042734	presynaptic membrane	Htr3a	IDA		Rat	PMID:12592509|RGD:13702377
Cellular Component	GO:1904602	serotonin-activated cation-selective channel complex	HTR3A	IPI		Human	PMID:16116092
Cellular Component	GO:1904602	serotonin-activated cation-selective channel complex	HTR3A	IPI		Human	PMID:17392525
Cellular Component	GO:1904602	serotonin-activated cation-selective channel complex	HTR3A	IDA		Human	PMID:9950429
Cellular Component	GO:1904602	serotonin-activated cation-selective channel complex	Htr3a	IPI		Mouse	MGI:MGI:5916607|PMID:25119048
Biological Process	GO:0071363	cellular response to growth factor stimulus	Htr3a	IEP		Rat	PMID:10854267|RGD:61635
Biological Process	GO:0098662	inorganic cation transmembrane transport	HTR3A	IDA		Human	PMID:17392525
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Htr3a	IDA		Mouse	MGI:MGI:7316535|PMID:25989383
Biological Process	GO:0032414	positive regulation of ion transmembrane transporter activity	Htr3a	IDA		Rat	PMID:10854267|RGD:61635
Biological Process	GO:0099505	regulation of presynaptic membrane potential	Htr3a	IDA		Mouse	MGI:MGI:7316535|PMID:25989383
Biological Process	GO:0042220	response to cocaine	Htr3a	IEP		Rat	PMID:17105936|RGD:2316965
Biological Process	GO:0045471	response to ethanol	Htr3a	IEP		Rat	PMID:16876304|RGD:6480656
Biological Process	GO:0007210	serotonin receptor signaling pathway	HTR3A	IDA		Human	PMID:17392525

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern