Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HTR5A
  • Mouse genes Htr5a
  • Rat genes Htr5a
  • Zfish genes htr5aa,htr5ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Htr5a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	HTR5A	IDA		Human	PMID:7988681
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr5a	IMP		Rat	PMID:7682702|RGD:62385
Cellular Component	GO:0030425	dendrite	Htr5a	IDA		Rat	PMID:17394137|RGD:2316992
Cellular Component	GO:0005794	Golgi apparatus	Htr5a	IDA		Rat	PMID:17394137|RGD:2316992
Cellular Component	GO:0043204	perikaryon	Htr5a	IDA		Rat	PMID:15282708|RGD:2316996
Cellular Component	GO:0099634	postsynaptic specialization membrane	Htr5a	IDA		Rat	PMID:16082681|RGD:6480682
Cellular Component	GO:0005791	rough endoplasmic reticulum	Htr5a	IDA		Rat	PMID:17394137|RGD:2316992
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Htr5a	IDA		Mouse	PMID:11406289
Biological Process	GO:0007420	brain development	Htr5a	IEP		Rat	PMID:15823424|RGD:1578542
Biological Process	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Htr5a	IMP		Rat	PMID:10861802|RGD:2316997
Biological Process	GO:0021766	hippocampus development	Htr5a	IEP		Rat	PMID:16572590|RGD:2316993
Biological Process	GO:0032355	response to estradiol	Htr5a	IEP		Rat	PMID:17122082|RGD:1642579

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern