Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HTR6
  • Mouse genes Htr6
  • Rat genes Htr6
  • Zfish genes htr6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Htr6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr6	IDA		Rat	PMID:7680751|RGD:729174
Molecular Function	GO:0005515	protein binding	HTR6	IPI	UniProtKB:P06241	Human	PMID:17189269
Molecular Function	GO:0005515	protein binding	HTR6	IPI	UniProtKB:P21359	Human	PMID:23027611
Molecular Function	GO:0005515	protein binding	HTR6	IPI	UniProtKB:P42345	Human	PMID:23027611
Molecular Function	GO:0005515	protein binding	HTR6	IPI	UniProtKB:Q8N122	Human	PMID:23027611
Molecular Function	GO:0005515	protein binding	HTR6	IPI	UniProtKB:P46821	Human	PMID:24614691
Molecular Function	GO:0005515	protein binding	HTR6	IPI	UniProtKB:P51513	Human	PMID:30853821
Molecular Function	GO:0005515	protein binding	Htr6	IPI	UniProtKB:P49615	Mouse	MGI:MGI:5607347|PMID:25078650
Molecular Function	GO:0005515	protein binding	Htr6	IPI	UniProtKB:Q9JLN9	Mouse	MGI:MGI:5607214|PMID:23027611
Molecular Function	GO:0005515	protein binding	Htr6	IPI	UniProtKB:P15205	Rat	PMID:24614691|RGD:11055045
Cellular Component	GO:0005929	cilium	Htr6	IDA		Mouse	PMID:22179047
Cellular Component	GO:0030425	dendrite	Htr6	IDA		Rat	PMID:10432491|RGD:2317011
Cellular Component	GO:0005886	plasma membrane	Htr6	IDA		Rat	PMID:10924708|RGD:2317009
Biological Process	GO:0007420	brain development	Htr6	IEP		Rat	PMID:9606024|RGD:2317013
Biological Process	GO:0021795	cerebral cortex cell migration	Htr6	IMP		Mouse	MGI:MGI:5607347|PMID:25078650
Biological Process	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Htr6	IMP		Rat	PMID:7680751|RGD:729174
Biological Process	GO:0007612	learning	Htr6	IDA		Rat	PMID:17192775|RGD:2316999
Biological Process	GO:0060291	long-term synaptic potentiation	Htr6	IMP		Rat	PMID:19660530|RGD:2316998
Biological Process	GO:0014058	negative regulation of acetylcholine secretion, neurotransmission	Htr6	IMP		Rat	PMID:16987217|RGD:2317005
Biological Process	GO:0014053	negative regulation of gamma-aminobutyric acid secretion	Htr6	IMP		Rat	PMID:16987217|RGD:2317005
Biological Process	GO:0014050	negative regulation of glutamate secretion	Htr6	IMP		Rat	PMID:16987217|RGD:2317005
Biological Process	GO:0033603	positive regulation of dopamine secretion	Htr6	IMP		Rat	PMID:16987217|RGD:2317005
Biological Process	GO:0014054	positive regulation of gamma-aminobutyric acid secretion	Htr6	IMP		Rat	PMID:19660530|RGD:2316998
Biological Process	GO:0032008	positive regulation of TOR signaling	HTR6	IDA		Human	PMID:23027611
Biological Process	GO:0032008	positive regulation of TOR signaling	Htr6	IDA		Mouse	MGI:MGI:5607214|PMID:23027611
Biological Process	GO:0032355	response to estradiol	Htr6	IEP		Rat	PMID:17122082|RGD:1642579
Biological Process	GO:0009410	response to xenobiotic stimulus	Htr6	IEP		Rat	PMID:10427606|RGD:2317012

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern