Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HTR7
  • Mouse genes Htr7
  • Rat genes Htr7
  • Zfish genes htr7a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Htr7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr7	IDA		Rat	PMID:8394362|RGD:625369
Molecular Function	GO:0030594	neurotransmitter receptor activity	Htr7	IDA		Rat	PMID:8394362|RGD:625369
Molecular Function	GO:0005515	protein binding	HTR7	IPI	UniProtKB:P43243	Human	PMID:19486527
Molecular Function	GO:0005515	protein binding	HTR7	IPI	UniProtKB:P43243	Human	PMID:30021884
Cellular Component	GO:0043679	axon terminus	Htr7	IDA		Rat	PMID:16082681|RGD:6480682
Cellular Component	GO:0030425	dendrite	Htr7	IDA		Rat	PMID:16082681|RGD:6480682
Cellular Component	GO:0043025	neuronal cell body	Htr7	IDA		Rat	PMID:16082681|RGD:6480682
Cellular Component	GO:0045211	postsynaptic membrane	Htr7	IDA		Rat	PMID:16082681|RGD:6480682
Cellular Component	GO:0042734	presynaptic membrane	Htr7	IDA		Rat	PMID:16082681|RGD:6480682
Cellular Component	GO:0005791	rough endoplasmic reticulum	Htr7	IDA		Rat	PMID:16082681|RGD:6480682
Cellular Component	GO:0008021	synaptic vesicle	Htr7	IDA		Rat	PMID:16082681|RGD:6480682
Biological Process	GO:0007192	adenylate cyclase-activating serotonin receptor signaling pathway	Htr7	IDA		Rat	PMID:8394362|RGD:625369
Biological Process	GO:0048266	behavioral response to pain	Htr7	IMP		Rat	PMID:16098671|RGD:6480679
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	Htr7	IDA		Rat	PMID:21843960|RGD:6482179
Biological Process	GO:0071542	dopaminergic neuron differentiation	Htr7	IMP		Rat	PMID:17443768|RGD:6480676
Biological Process	GO:0060291	long-term synaptic potentiation	Htr7	IMP		Rat	PMID:22314569|RGD:6480664
Biological Process	GO:0007613	memory	Htr7	IMP		Rat	PMID:18308404|RGD:6480670
Biological Process	GO:0060073	micturition	Htr7	IMP		Rat	PMID:12967934|RGD:6480687
Biological Process	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep	Htr7	IDA		Rat	PMID:18466985|RGD:6480669
Biological Process	GO:0014063	negative regulation of serotonin secretion	Htr7	IMP		Rat	PMID:15260125|RGD:6480684
Biological Process	GO:0010976	positive regulation of neuron projection development	Htr7	IDA		Rat	PMID:19243449|RGD:6482183
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Htr7	EXP		Rat	PMID:26779891|RGD:13702205
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Htr7	IDA		Rat	PMID:26779891|RGD:13702205
Biological Process	GO:0062086	regulation of vein smooth muscle contraction	Htr7	IMP		Rat	PMID:31125290|RGD:14696717
Biological Process	GO:0051412	response to corticosterone	Htr7	IDA		Rat	PMID:19617650|RGD:6480668
Biological Process	GO:0051602	response to electrical stimulus	Htr7	IEP		Rat	PMID:18195451|RGD:6480672
Biological Process	GO:0007210	serotonin receptor signaling pathway	Htr7	IDA		Rat	PMID:8394362|RGD:625369
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	Htr7	IMP		Rat	PMID:20969855|RGD:6480667

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern