Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HTRA2
  • Mouse genes Htra2
  • Rat genes Htra2
  • Zfish genes si:busm1-sl7.7,si:dkey-10b15.8,si:dkey-112g5.13,si:dkey-112g5.16,si:dkey-19p15.4,si:dkey-33c12.10,si:dkey-33c12.11,si:dkey-33c12.12,si:dkey-33c12.13,si:dkey-84o3.2,si:dkey-84o3.7,zgc:174193
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Htra2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	HTRA2	IPI	UniProtKB:O43464	Human	PMID:11967569
Molecular Function	GO:0008233	peptidase activity	HTRA2	IDA		Human	PMID:11604410
Molecular Function	GO:0008233	peptidase activity	HTRA2	IDA		Human	PMID:17266347
Molecular Function	GO:0008233	peptidase activity	HTRA2	IDA		Human	PMID:20125124
Molecular Function	GO:0008233	peptidase activity	HTRA2	IMP		Human	PMID:24709290
Molecular Function	GO:0008233	peptidase activity	HTRA2	IDA		Human	PMID:25118933
Molecular Function	GO:0008233	peptidase activity	Htra2	IMP		Mouse	MGI:MGI:5581539|PMID:24709290
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P02666	Human	PMID:10971580
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P98170	Human	PMID:11583623
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P98170	Human	PMID:11602612
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P98170	Human	PMID:11604410
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P98170	Human	PMID:11801603
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q96CA5	Human	PMID:11801603
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q9NR09	Human	PMID:15200957
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q9P0J0	Human	PMID:17297443
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q7Z6K1	Human	PMID:19502560
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q60855	Human	PMID:20125124
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:O15033,UniProtKB:O43236,UniProtKB:Q9NR28	Human	PMID:23479728
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P02666	Human	PMID:24698088
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P98170	Human	PMID:24698088
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P49841	Human	PMID:25118933
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P02666	Human	PMID:28642151
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P98170	Human	PMID:28642151
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P02666	Human	PMID:31470122
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P98170	Human	PMID:31470122
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P98170	Human	PMID:31617661
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q6DKK2	Human	PMID:31617661
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q9P0J0	Human	PMID:31617661
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:O00303	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:O00308	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:O14813	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:O15381-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:O15535	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:O60304	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:O75604-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:O75925	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:O95150	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P02489	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P08727	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P17980	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P24278	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P57052	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:P57682	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q02363	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q13216-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q13562	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q14525	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q15007-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q16637-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q1L5Z9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q495M9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q5TAQ9-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q5VWN6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q6DKK2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q6GQQ9-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q6P597	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q6ZMI0-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q6ZTN6-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q7Z7K6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q86TN1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q86V28	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q86WV5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q8IY31-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q8N0Y2-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q8N488	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q8N594	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q8N5Z5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q8N6K7-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q8NA82	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q8NEZ2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q8TC29	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q8WVD3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q8WWB5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q8WXH5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q8WY64	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q96D59	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q96DX5-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q96FT7-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q96FW1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q96GM5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q96GQ5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q96T49	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q99683	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q99871	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q9HBE1-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q9NR46	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q9NUU6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q9NV79	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q9UNY5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q9Y2M5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HTRA2	IPI	UniProtKB:Q9Y575-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Htra2	IPI	UniProtKB:P28661,UniProtKB:Q8CHG5,UniProtKB:Q9JIQ3	Mouse	MGI:MGI:5498443|PMID:23479728
Molecular Function	GO:0005515	protein binding	Htra2	IPI	UniProtKB:O35387	Mouse	MGI:MGI:3776580|PMID:18288109
Molecular Function	GO:0005515	protein binding	Htra2	IPI	UniProtKB:Q99MS3-1|UniProtKB:Q99MS3-3|UniProtKB:Q99MS3	Mouse	MGI:MGI:6092999|PMID:18772386
Molecular Function	GO:0005515	protein binding	Htra2	IPI	UniProtKB:P98170|UniProtKB:Q60989	Mouse	MGI:MGI:5315367|PMID:11604410
Molecular Function	GO:0004252	serine-type endopeptidase activity	HTRA2	IMP		Human	PMID:10971580
Molecular Function	GO:0004252	serine-type endopeptidase activity	HTRA2	IMP		Human	PMID:11967569
Molecular Function	GO:0008236	serine-type peptidase activity	HTRA2	IDA		Human	PMID:11583623
Molecular Function	GO:0008236	serine-type peptidase activity	Htra2	IMP		Rat	PMID:16978742|RGD:2314385
Cellular Component	GO:0035631	CD40 receptor complex	Htra2	IDA		Mouse	MGI:MGI:4462284|PMID:20614026
Cellular Component	GO:0000785	chromatin	HTRA2	IDA		Human	PMID:24798695
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	Htra2	IDA		Mouse	MGI:MGI:4462284|PMID:20614026
Cellular Component	GO:0005856	cytoskeleton	HTRA2	IDA		Human	PMID:24798695
Cellular Component	GO:0005829	cytosol	HTRA2	IDA		Human	PMID:11583623
Cellular Component	GO:0005829	cytosol	HTRA2	IDA		Human	PMID:11602612
Cellular Component	GO:0005829	cytosol	HTRA2	IDA		Human	PMID:11604410
Cellular Component	GO:0005829	cytosol	HTRA2	IDA		Human	PMID:24798695
Cellular Component	GO:0005829	cytosol	Htra2	IDA		Rat	PMID:16978742|RGD:2314385
Cellular Component	GO:0005829	cytosol	Htra2	IDA		Rat	PMID:17182030|RGD:2314398
Cellular Component	GO:0016020	membrane	HTRA2	IDA		Human	PMID:24798695
Cellular Component	GO:0005758	mitochondrial intermembrane space	HTRA2	IDA		Human	PMID:15044455
Cellular Component	GO:0005739	mitochondrion	HTRA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	HTRA2	IDA		Human	PMID:11583623
Cellular Component	GO:0005739	mitochondrion	HTRA2	IDA		Human	PMID:11602612
Cellular Component	GO:0005739	mitochondrion	HTRA2	IMP		Human	PMID:11604410
Cellular Component	GO:0005739	mitochondrion	Htra2	IDA		Mouse	MGI:MGI:5546003|PMID:11602612
Cellular Component	GO:0005739	mitochondrion	Htra2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Htra2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Htra2	IDA		Rat	PMID:16978742|RGD:2314385
Cellular Component	GO:0005739	mitochondrion	Htra2	IDA		Rat	PMID:17182030|RGD:2314398
Cellular Component	GO:0005634	nucleus	HTRA2	IDA		Human	PMID:10971580
Cellular Component	GO:0005634	nucleus	HTRA2	IDA		Human	PMID:24798695
Cellular Component	GO:1905370	serine-type endopeptidase complex	HTRA2	IMP		Human	PMID:11967569
Biological Process	GO:0008344	adult locomotory behavior	Htra2	IMP	MGI:MGI:3512633	Mouse	PMID:15509788
Biological Process	GO:0007628	adult walking behavior	Htra2	IMP	MGI:MGI:1856960	Mouse	PMID:8325640
Biological Process	GO:0007568	aging	Htra2	IEP		Rat	PMID:22535253|RGD:10402935
Biological Process	GO:0071363	cellular response to growth factor stimulus	HTRA2	IMP		Human	PMID:20125124
Biological Process	GO:0034605	cellular response to heat	HTRA2	IDA		Human	PMID:10971580
Biological Process	GO:0035458	cellular response to interferon-beta	HTRA2	IDA		Human	PMID:17297443
Biological Process	GO:0034599	cellular response to oxidative stress	HTRA2	IMP		Human	PMID:24709290
Biological Process	GO:0034599	cellular response to oxidative stress	Htra2	IMP		Mouse	MGI:MGI:5581539|PMID:24709290
Biological Process	GO:0071300	cellular response to retinoic acid	HTRA2	IDA		Human	PMID:17297443
Biological Process	GO:0006672	ceramide metabolic process	Htra2	IEP		Rat	PMID:22296759|RGD:5688365
Biological Process	GO:0030900	forebrain development	Htra2	IMP	MGI:MGI:3512633	Mouse	PMID:15509788
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	Htra2	IMP	MGI:MGI:3512633	Mouse	PMID:15509788
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	HTRA2	IMP		Human	PMID:11602612
Biological Process	GO:0007005	mitochondrion organization	Htra2	IMP	MGI:MGI:3512633	Mouse	PMID:15574596
Biological Process	GO:1904924	negative regulation of mitophagy in response to mitochondrial depolarization	Htra2	IMP		Mouse	MGI:MGI:5581539|PMID:24709290
Biological Process	GO:0051402	neuron apoptotic process	Htra2	IMP		Rat	PMID:18662332|RGD:5688723
Biological Process	GO:0048666	neuron development	Htra2	IMP	MGI:MGI:1856960	Mouse	PMID:8325640
Biological Process	GO:0019742	pentacyclic triterpenoid metabolic process	Htra2	IEP		Rat	PMID:22296759|RGD:5688365
Biological Process	GO:0043065	positive regulation of apoptotic process	HTRA2	IMP		Human	PMID:11967569
Biological Process	GO:0043065	positive regulation of apoptotic process	HTRA2	IMP		Human	PMID:20125124
Biological Process	GO:0043065	positive regulation of apoptotic process	Htra2	IMP		Mouse	MGI:MGI:5315367|PMID:11604410
Biological Process	GO:0043065	positive regulation of apoptotic process	Htra2	IMP		Rat	PMID:16978742|RGD:2314385
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	HTRA2	IDA		Human	PMID:11583623
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	HTRA2	IDA		Human	PMID:11604410
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	HTRA2	IMP		Human	PMID:11967569
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	HTRA2	IDA		Human	PMID:17297443
Biological Process	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	HTRA2	IMP		Human	PMID:11602612
Biological Process	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	HTRA2	IMP		Human	PMID:20125124
Biological Process	GO:0010822	positive regulation of mitochondrion organization	HTRA2	IMP		Human	PMID:25118933
Biological Process	GO:1903955	positive regulation of protein targeting to mitochondrion	HTRA2	HMP		Human	PMID:24270810
Biological Process	GO:0012501	programmed cell death	HTRA2	IDA		Human	PMID:11583623
Biological Process	GO:0030163	protein catabolic process	HTRA2	IDA		Human	PMID:17297443
Biological Process	GO:0006508	proteolysis	HTRA2	IMP		Human	PMID:10971580
Biological Process	GO:0006508	proteolysis	HTRA2	IMP		Human	PMID:11967569
Biological Process	GO:0006508	proteolysis	HTRA2	IMP		Human	PMID:24709290
Biological Process	GO:0006508	proteolysis	HTRA2	IDA		Human	PMID:25118933
Biological Process	GO:0006508	proteolysis	Htra2	IMP		Mouse	MGI:MGI:5581539|PMID:24709290
Biological Process	GO:0040014	regulation of multicellular organism growth	Htra2	IMP	MGI:MGI:3512633	Mouse	PMID:15509788
Biological Process	GO:0040014	regulation of multicellular organism growth	Htra2	IMP	MGI:MGI:1856960	Mouse	PMID:8325640
Biological Process	GO:0009635	response to herbicide	Htra2	IEP		Rat	PMID:22245251|RGD:5688383

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern