Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HUWE1
  • Mouse genes Huwe1
  • Rat genes Huwe1
  • Zfish genes huwe1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Huwe1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Huwe1	IDA		Rat	PMID:7968380|RGD:8554643
Molecular Function	GO:0005515	protein binding	HUWE1	IPI	UniProtKB:P04637	Human	PMID:15989956
Molecular Function	GO:0005515	protein binding	HUWE1	IPI	UniProtKB:Q8N726	Human	PMID:15989956
Molecular Function	GO:0005515	protein binding	HUWE1	IPI	UniProtKB:P06746	Human	PMID:19713937
Molecular Function	GO:0005515	protein binding	HUWE1	IPI	UniProtKB:Q07820	Human	PMID:20023629
Molecular Function	GO:0005515	protein binding	HUWE1	IPI	UniProtKB:P20393	Human	PMID:20534529
Molecular Function	GO:0005515	protein binding	HUWE1	IPI	UniProtKB:Q07820	Human	PMID:21507240
Molecular Function	GO:0005515	protein binding	HUWE1	IPI	UniProtKB:Q13107	Human	PMID:21522127
Molecular Function	GO:0005515	protein binding	HUWE1	IPI	UniProtKB:P04792	Human	PMID:25277244
Molecular Function	GO:0005515	protein binding	HUWE1	IPI	UniProtKB:Q8N726	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	HUWE1	IPI	UniProtKB:Q96C12	Human	PMID:28169274
Molecular Function	GO:0005515	protein binding	HUWE1	IPI	UniProtKB:Q9C0C7	Human	PMID:30217973
Molecular Function	GO:0005515	protein binding	HUWE1	IPI	UniProtKB:Q14CZ0	Human	PMID:35776542
Molecular Function	GO:0005515	protein binding	HUWE1	IPI	UniProtKB:A0A7P0TBJ1	Human	PMID:36631436
Molecular Function	GO:0005515	protein binding	Huwe1	IPI	UniProtKB:A0A0G2K916,UniProtKB:B2GV38,UniProtKB:B5DFN4,UniProtKB:D3Z941,UniProtKB:D4AA63,UniProtKB:F1M853,UniProtKB:P11250,UniProtKB:P61107,UniProtKB:P62718,UniProtKB:P97612,UniProtKB:Q09167,UniProtKB:Q498M4,UniProtKB:Q5PPJ6,UniProtKB:Q5PPK9,UniProtKB:Q63569,UniProtKB:Q6AYJ7	Rat	PMID:27191843|RGD:11344934
Molecular Function	GO:0003723	RNA binding	HUWE1	HDA		Human	PMID:22658674
Molecular Function	GO:0061630	ubiquitin protein ligase activity	HUWE1	IMP		Human	PMID:26214738
Molecular Function	GO:0061630	ubiquitin protein ligase activity	HUWE1	IDA		Human	PMID:30217973
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	HUWE1	IDA		Human	PMID:15989957
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	HUWE1	IDA		Human	PMID:19713937
Cellular Component	GO:0005737	cytoplasm	HUWE1	IDA		Human	PMID:19713937
Cellular Component	GO:0005829	cytosol	HUWE1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	HUWE1	HDA		Human	PMID:19056867
Cellular Component	GO:0016020	membrane	HUWE1	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	HUWE1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Huwe1	IDA		Rat	PMID:7968380|RGD:8554643
Biological Process	GO:0006284	base-excision repair	HUWE1	IMP		Human	PMID:19713937
Biological Process	GO:0032922	circadian regulation of gene expression	HUWE1	IMP		Human	PMID:20534529
Biological Process	GO:0032922	circadian regulation of gene expression	Huwe1	IMP		Mouse	MGI:MGI:4458969|PMID:20534529
Biological Process	GO:0016574	histone ubiquitination	HUWE1	IDA		Human	PMID:15767685
Biological Process	GO:0010637	negative regulation of mitochondrial fusion	HUWE1	IMP		Human	PMID:26214738
Biological Process	GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization	HUWE1	IDA		Human	PMID:30217973
Biological Process	GO:1903955	positive regulation of protein targeting to mitochondrion	HUWE1	HMP		Human	PMID:24270810
Biological Process	GO:0031398	positive regulation of protein ubiquitination	HUWE1	IDA		Human	PMID:20534529
Biological Process	GO:0031398	positive regulation of protein ubiquitination	Huwe1	IDA		Mouse	MGI:MGI:4458969|PMID:20534529
Biological Process	GO:0006513	protein monoubiquitination	HUWE1	IDA		Human	PMID:19713937
Biological Process	GO:0000209	protein polyubiquitination	HUWE1	IDA		Human	PMID:15989957

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern