Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HYAL2
  • Mouse genes Hyal2
  • Rat genes Hyal2
  • Zfish genes hyal2a,hyal2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hyal2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	HYAL2	IPI	UniProtKB:Q9NZC7	Human	PMID:19366691
Molecular Function	GO:0019899	enzyme binding	Hyal2	IPI	UniProtKB:Q91WL8	Mouse	MGI:MGI:3851310|PMID:19366691
Molecular Function	GO:0005540	hyaluronic acid binding	HYAL2	IDA		Human	PMID:12676986
Molecular Function	GO:0005540	hyaluronic acid binding	HYAL2	IDA		Human	PMID:19443707
Molecular Function	GO:0033906	hyaluronoglucuronidase activity	HYAL2	IDA		Human	PMID:21699545
Molecular Function	GO:0033906	hyaluronoglucuronidase activity	Hyal2	IDA		Rat	PMID:19635555|RGD:8553259
Molecular Function	GO:0004415	hyalurononglucosaminidase activity	HYAL2	IDA		Human	PMID:11944887
Molecular Function	GO:0004415	hyalurononglucosaminidase activity	HYAL2	IDA		Human	PMID:16600643
Molecular Function	GO:0004415	hyalurononglucosaminidase activity	HYAL2	IDA		Human	PMID:17170110
Molecular Function	GO:0004415	hyalurononglucosaminidase activity	HYAL2	IDA		Human	PMID:18390475
Molecular Function	GO:0004415	hyalurononglucosaminidase activity	HYAL2	IDA		Human	PMID:19443707
Molecular Function	GO:0004415	hyalurononglucosaminidase activity	HYAL2	IDA		Human	PMID:20554532
Molecular Function	GO:0004415	hyalurononglucosaminidase activity	HYAL2	IDA		Human	PMID:9712871
Molecular Function	GO:0004415	hyalurononglucosaminidase activity	Hyal2	IMP	MGI:MGI:3836764	Mouse	PMID:26887442
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:P31621	Human	PMID:12676986
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:P31621	Human	PMID:16191204
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:Q13643	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:Q9BYR7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:O76011	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:Q07627	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:Q3LI66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:Q9HAT8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:P05067-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:P14136	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:P29474	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:P49768-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HYAL2	IPI	UniProtKB:Q9UBB4	Human	PMID:32814053
Molecular Function	GO:0030294	receptor signaling protein tyrosine kinase inhibitor activity	HYAL2	IDA		Human	PMID:12676986
Molecular Function	GO:0030971	receptor tyrosine kinase binding	HYAL2	IPI	UniProtKB:Q04912	Human	PMID:12676986
Molecular Function	GO:0003713	transcription coactivator activity	Hyal2	IDA		Mouse	MGI:MGI:3851310|PMID:19366691
Molecular Function	GO:0050431	transforming growth factor beta binding	Hyal2	IPI	UniProtKB:P01137	Mouse	MGI:MGI:3851310|PMID:19366691
Molecular Function	GO:0001618	virus receptor activity	HYAL2	IDA		Human	PMID:11296287
Molecular Function	GO:0001618	virus receptor activity	HYAL2	IDA		Human	PMID:16191204
Molecular Function	GO:0001618	virus receptor activity	Hyal2	IDA		Mouse	MGI:MGI:5315372|PMID:11296287
Cellular Component	GO:0016324	apical plasma membrane	HYAL2	IDA		Human	PMID:20554532
Cellular Component	GO:0009986	cell surface	HYAL2	IDA		Human	PMID:17170110
Cellular Component	GO:0009986	cell surface	Hyal2	IDA		Mouse	MGI:MGI:3851310|PMID:19366691
Cellular Component	GO:0005737	cytoplasm	HYAL2	IDA		Human	PMID:17170110
Cellular Component	GO:0031410	cytoplasmic vesicle	HYAL2	IDA		Human	PMID:16600643
Cellular Component	GO:0031410	cytoplasmic vesicle	HYAL2	IDA		Human	PMID:18390475
Cellular Component	GO:0005829	cytosol	HYAL2	IDA		Human	PMID:19366691
Cellular Component	GO:0030139	endocytic vesicle	HYAL2	IDA		Human	PMID:19366691
Cellular Component	GO:0009897	external side of plasma membrane	HYAL2	IDA		Human	PMID:19443707
Cellular Component	GO:0009897	external side of plasma membrane	HYAL2	IDA		Human	PMID:11296287
Cellular Component	GO:0009897	external side of plasma membrane	HYAL2	IDA		Human	PMID:16191204
Cellular Component	GO:0009897	external side of plasma membrane	HYAL2	IDA		Human	PMID:20554532
Cellular Component	GO:0009897	external side of plasma membrane	Hyal2	IDA		Mouse	MGI:MGI:3847143|PMID:19443707
Cellular Component	GO:0000139	Golgi membrane	Hyal2	IDA		Rat	PMID:21740893|RGD:8553444
Cellular Component	GO:0005764	lysosome	HYAL2	IDA		Human	PMID:16600643
Cellular Component	GO:0005764	lysosome	HYAL2	IDA		Human	PMID:9712871
Cellular Component	GO:0045121	membrane raft	HYAL2	IDA		Human	PMID:21740893
Cellular Component	GO:0045121	membrane raft	Hyal2	IDA		Mouse	MGI:MGI:5318001|PMID:21740893
Cellular Component	GO:0045121	membrane raft	Hyal2	IDA		Rat	PMID:21740893|RGD:8553444
Cellular Component	GO:0005902	microvillus	HYAL2	IDA		Human	PMID:19366691
Cellular Component	GO:0048471	perinuclear region of cytoplasm	HYAL2	IDA		Human	PMID:16600643
Cellular Component	GO:0005886	plasma membrane	HYAL2	IDA		Human	PMID:18390475
Cellular Component	GO:0005886	plasma membrane	HYAL2	IDA		Human	PMID:21740893
Cellular Component	GO:0005886	plasma membrane	Hyal2	IDA		Mouse	MGI:MGI:5318001|PMID:21740893
Cellular Component	GO:0005886	plasma membrane	Hyal2	IDA		Rat	PMID:21740893|RGD:8553444
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	Hyal2	IDA		Mouse	MGI:MGI:3851310|PMID:19366691
Biological Process	GO:0051216	cartilage development	HYAL2	IEP		Human	PMID:11944887
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	HYAL2	IDA		Human	PMID:19577615
Biological Process	GO:0071347	cellular response to interleukin-1	HYAL2	IDA		Human	PMID:18390475
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	HYAL2	IDA		Human	PMID:19366691
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Hyal2	IDA		Mouse	MGI:MGI:3851310|PMID:19366691
Biological Process	GO:0071356	cellular response to tumor necrosis factor	HYAL2	IEP		Human	PMID:18390475
Biological Process	GO:0071493	cellular response to UV-B	HYAL2	IDA		Human	PMID:21699545
Biological Process	GO:0051607	defense response to virus	Hyal2	IDA		Mouse	MGI:MGI:5315349|PMID:16191204
Biological Process	GO:0019064	fusion of virus membrane with host plasma membrane	HYAL2	IDA		Human	PMID:11296287
Biological Process	GO:0006027	glycosaminoglycan catabolic process	HYAL2	IDA		Human	PMID:9712871
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Hyal2	IMP	MGI:MGI:3836764	Mouse	PMID:18772348
Biological Process	GO:0030214	hyaluronan catabolic process	HYAL2	IDA		Human	PMID:17170110
Biological Process	GO:0030214	hyaluronan catabolic process	HYAL2	IDA		Human	PMID:19443707
Biological Process	GO:0030214	hyaluronan catabolic process	HYAL2	IDA		Human	PMID:20554532
Biological Process	GO:0030214	hyaluronan catabolic process	HYAL2	IDA		Human	PMID:21699545
Biological Process	GO:0030214	hyaluronan catabolic process	Hyal2	IMP	MGI:MGI:3836764	Mouse	PMID:23172227
Biological Process	GO:0030214	hyaluronan catabolic process	Hyal2	IMP	MGI:MGI:3836764	Mouse	PMID:26887442
Biological Process	GO:0030214	hyaluronan catabolic process	Hyal2	IDA		Rat	PMID:19635555|RGD:8553259
Biological Process	GO:0001822	kidney development	Hyal2	IEP		Rat	PMID:17706761|RGD:8553275
Biological Process	GO:0042117	monocyte activation	HYAL2	IDA		Human	PMID:19443707
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Hyal2	IMP	MGI:MGI:3836764	Mouse	PMID:18772348
Biological Process	GO:0030308	negative regulation of cell growth	HYAL2	IDA		Human	PMID:18725949
Biological Process	GO:0010764	negative regulation of fibroblast migration	HYAL2	IDA		Human	PMID:19577615
Biological Process	GO:0043407	negative regulation of MAP kinase activity	HYAL2	IDA		Human	PMID:12676986
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	HYAL2	IDA		Human	PMID:12676986
Biological Process	GO:0061099	negative regulation of protein tyrosine kinase activity	HYAL2	IDA		Human	PMID:12676986
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	Hyal2	IMP		Mouse	MGI:MGI:3851310|PMID:19366691
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	Hyal2	IDA		Mouse	PMID:19366691
Biological Process	GO:0050729	positive regulation of inflammatory response	HYAL2	IDA		Human	PMID:19443707
Biological Process	GO:0032755	positive regulation of interleukin-6 production	HYAL2	IDA		Human	PMID:19443707
Biological Process	GO:0032757	positive regulation of interleukin-8 production	HYAL2	IDA		Human	PMID:19443707
Biological Process	GO:0042307	positive regulation of protein import into nucleus	Hyal2	IDA		Mouse	MGI:MGI:3851310|PMID:19366691
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hyal2	IDA		Mouse	MGI:MGI:3851310|PMID:19366691
Biological Process	GO:0035810	positive regulation of urine volume	Hyal2	IEP		Rat	PMID:19635555|RGD:8553259
Biological Process	GO:0070295	renal water absorption	Hyal2	IEP		Rat	PMID:19635555|RGD:8553259
Biological Process	GO:0046677	response to antibiotic	HYAL2	IEP		Human	PMID:11944887
Biological Process	GO:0000302	response to reactive oxygen species	HYAL2	IDA		Human	PMID:20554532
Biological Process	GO:0009615	response to virus	HYAL2	IDA		Human	PMID:11296287
Biological Process	GO:0009615	response to virus	HYAL2	IDA		Human	PMID:12676986
Biological Process	GO:0009615	response to virus	Hyal2	IDA		Mouse	MGI:MGI:5315372|PMID:11296287
Biological Process	GO:0048705	skeletal system morphogenesis	Hyal2	IMP	MGI:MGI:3836764	Mouse	PMID:18772348
Biological Process	GO:0046718	viral entry into host cell	Hyal2	IDA		Rat	PMID:12584308|RGD:633153

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern