Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IDE
  • Mouse genes Ide
  • Rat genes Ide
  • Zfish genes ide
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ide

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	Ide	IPI	RGD:2139	Rat	PMID:18411275|RGD:2325981
Molecular Function	GO:0005524	ATP binding	IDE	IDA		Human	PMID:17613531
Molecular Function	GO:0005524	ATP binding	Ide	IMP		Rat	PMID:15749695|RGD:1626704
Molecular Function	GO:0005524	ATP binding	Ide	IPI	CHEBI:15422	Rat	PMID:17259336|RGD:1627573
Molecular Function	GO:0016887	ATP hydrolysis activity	Ide	IDA		Rat	PMID:17259336|RGD:1627573
Molecular Function	GO:0031626	beta-endorphin binding	Ide	IMP		Rat	PMID:15749695|RGD:1626704
Molecular Function	GO:0004175	endopeptidase activity	IDE	IDA		Human	PMID:20364150
Molecular Function	GO:0004175	endopeptidase activity	Ide	IDA		Mouse	PMID:27703010
Molecular Function	GO:0042802	identical protein binding	Ide	IPI	RGD:2861	Rat	PMID:15494400|RGD:1626705
Molecular Function	GO:0043559	insulin binding	IDE	IDA		Human	PMID:17051221
Molecular Function	GO:0043559	insulin binding	IDE	IPI	UniProtKB:P01308	Human	PMID:20082125
Molecular Function	GO:0043559	insulin binding	Ide	IMP		Rat	PMID:15749695|RGD:1626704
Molecular Function	GO:0004222	metalloendopeptidase activity	IDE	IDA		Human	PMID:17051221
Molecular Function	GO:0004222	metalloendopeptidase activity	IDE	IDA		Human	PMID:17613531
Molecular Function	GO:0004222	metalloendopeptidase activity	Ide	IDA		Rat	PMID:15494400|RGD:1626705
Molecular Function	GO:0004222	metalloendopeptidase activity	Ide	IMP		Rat	PMID:15749695|RGD:1626704
Molecular Function	GO:0042277	peptide binding	IDE	IPI	UniProtKB:P51460	Human	PMID:20082125
Molecular Function	GO:0017046	peptide hormone binding	Ide	IPI	RGD:3193	Rat	PMID:15494400|RGD:1626705
Molecular Function	GO:0005515	protein binding	IDE	IPI	UniProtKB:Q9J3M8	Human	PMID:17055432
Molecular Function	GO:0005515	protein binding	IDE	IPI	UniProtKB:Q9Y6E7	Human	PMID:17715127
Molecular Function	GO:0005515	protein binding	IDE	IPI	UniProtKB:P10147	Human	PMID:20959807
Molecular Function	GO:0005515	protein binding	IDE	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0042803	protein homodimerization activity	IDE	IDA		Human	PMID:17613531
Molecular Function	GO:0042803	protein homodimerization activity	IDE	IDA		Human	PMID:19321446
Molecular Function	GO:0044877	protein-containing complex binding	Ide	IDA		Rat	PMID:9000694|RGD:1627643
Molecular Function	GO:0140036	ubiquitin-dependent protein binding	IDE	IPI	UniProtKB:P0CG48	Human	PMID:21185309
Molecular Function	GO:0008270	zinc ion binding	IDE	IDA		Human	PMID:17613531
Molecular Function	GO:0008270	zinc ion binding	IDE	IDA		Human	PMID:19321446
Molecular Function	GO:0008270	zinc ion binding	Ide	IMP		Rat	PMID:15749695|RGD:1626704
Cellular Component	GO:0016323	basolateral plasma membrane	IDE	IMP		Human	PMID:16511862
Cellular Component	GO:0009986	cell surface	IDE	IDA		Human	PMID:16511862
Cellular Component	GO:0009986	cell surface	IDE	IDA		Human	PMID:17055432
Cellular Component	GO:0009986	cell surface	Ide	IDA		Rat	PMID:10684867|RGD:1627576
Cellular Component	GO:0005737	cytoplasm	IDE	IDA		Human	PMID:18226493
Cellular Component	GO:0005737	cytoplasm	IDE	IDA		Human	PMID:23525105
Cellular Component	GO:0005737	cytoplasm	IDE	IDA		Human	PMID:9231799
Cellular Component	GO:0005829	cytosol	IDE	IDA		Human	PMID:15285718
Cellular Component	GO:0005829	cytosol	IDE	IDA		Human	PMID:20364150
Cellular Component	GO:0005829	cytosol	IDE	IDA		Human	PMID:9830016
Cellular Component	GO:0005829	cytosol	Ide	IDA		Rat	PMID:15985623|RGD:1626702
Cellular Component	GO:0031597	cytosolic proteasome complex	Ide	IDA		Rat	PMID:9000694|RGD:1627643
Cellular Component	GO:0031904	endosome lumen	Ide	IDA		Mouse	PMID:27703010
Cellular Component	GO:0009897	external side of plasma membrane	IDE	IDA		Human	PMID:16511862
Cellular Component	GO:0070062	extracellular exosome	Ide	IMP		Mouse	MGI:MGI:6270905|PMID:20876579
Cellular Component	GO:0005615	extracellular space	IDE	IDA		Human	PMID:9830016
Cellular Component	GO:0005615	extracellular space	Ide	IDA		Rat	PMID:10684867|RGD:1627576
Cellular Component	GO:0005739	mitochondrion	IDE	IDA		Human	PMID:15285718
Cellular Component	GO:0005739	mitochondrion	IDE	IDA		Human	PMID:23525105
Cellular Component	GO:0005739	mitochondrion	Ide	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005634	nucleus	IDE	IDA		Human	PMID:15285718
Cellular Component	GO:0005634	nucleus	IDE	IDA		Human	PMID:9231799
Cellular Component	GO:0005634	nucleus	Ide	IDA		Rat	PMID:15985623|RGD:1626702
Cellular Component	GO:0005782	peroxisomal matrix	Ide	IDA		Rat	PMID:11235899|RGD:1627575
Cellular Component	GO:0005777	peroxisome	IDE	IDA		Human	PMID:9231799
Biological Process	GO:0097242	amyloid-beta clearance	IDE	IMP		Human	PMID:10684867
Biological Process	GO:0097242	amyloid-beta clearance	IDE	IMP		Human	PMID:16511862
Biological Process	GO:0097242	amyloid-beta clearance	Ide	IMP		Mouse	MGI:MGI:6270905|PMID:20876579
Biological Process	GO:0097242	amyloid-beta clearance	Ide	IDA		Mouse	PMID:26637123
Biological Process	GO:0097242	amyloid-beta clearance	Ide	IMP		Rat	PMID:10684867|RGD:1627576
Biological Process	GO:0097242	amyloid-beta clearance	Ide	IGI	UniProtKB:P15127,UniProtKB:P24062	Rat	PMID:19406747|RGD:13210538
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	IDE	IMP		Human	PMID:23525105
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	Ide	IMP		Rat	PMID:18941241|RGD:13825436
Biological Process	GO:0050435	amyloid-beta metabolic process	IDE	IDA		Human	PMID:17613531
Biological Process	GO:0050435	amyloid-beta metabolic process	IDE	IDA		Human	PMID:26968463
Biological Process	GO:0050435	amyloid-beta metabolic process	IDE	IDA		Human	PMID:9830016
Biological Process	GO:0050435	amyloid-beta metabolic process	Ide	IMP		Rat	PMID:15749695|RGD:1626704
Biological Process	GO:0050435	amyloid-beta metabolic process	Ide	IMP		Rat	PMID:18411275|RGD:2325981
Biological Process	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	IDE	IMP		Human	PMID:20364150
Biological Process	GO:0010815	bradykinin catabolic process	IDE	IDA		Human	PMID:17613531
Biological Process	GO:0010815	bradykinin catabolic process	IDE	IDA		Human	PMID:21185309
Biological Process	GO:0031018	endocrine pancreas development	ide	IMP	ZFIN:ZDB-MRPHLNO-160621-38	Zfish	PMID:26963759
Biological Process	GO:0042447	hormone catabolic process	IDE	IDA		Human	PMID:19321446
Biological Process	GO:0042447	hormone catabolic process	Ide	IDA		Rat	PMID:15494400|RGD:1626705
Biological Process	GO:1901143	insulin catabolic process	IDE	IDA		Human	PMID:19321446
Biological Process	GO:1901143	insulin catabolic process	IDE	IDA		Human	PMID:9231799
Biological Process	GO:1901143	insulin catabolic process	IDE	IDA		Human	PMID:9830016
Biological Process	GO:1901143	insulin catabolic process	Ide	IMP		Mouse	MGI:MGI:5583899|PMID:24847884
Biological Process	GO:1901143	insulin catabolic process	Ide	IDA		Mouse	PMID:27703010
Biological Process	GO:1901142	insulin metabolic process	IDE	IDA		Human	PMID:18448515
Biological Process	GO:0038020	insulin receptor recycling	Ide	IDA		Mouse	PMID:27703010
Biological Process	GO:0045861	negative regulation of proteolysis	Ide	IDA		Rat	PMID:9000694|RGD:1627643
Biological Process	GO:1990798	pancreas regeneration	ide	IMP	ZFIN:ZDB-MRPHLNO-160621-38	Zfish	PMID:26963759
Biological Process	GO:0043171	peptide catabolic process	IDE	IDA		Human	PMID:20364150
Biological Process	GO:0032092	positive regulation of protein binding	IDE	IDA		Human	PMID:9830016
Biological Process	GO:0030163	protein catabolic process	IDE	IMP		Human	PMID:20364150
Biological Process	GO:0030163	protein catabolic process	Ide	IMP		Mouse	MGI:MGI:6270905|PMID:20876579
Biological Process	GO:0030163	protein catabolic process	Ide	IDA		Rat	PMID:11235899|RGD:1627575
Biological Process	GO:0006508	proteolysis	IDE	IDA		Human	PMID:18602473
Biological Process	GO:0006508	proteolysis	IDE	IDA		Human	PMID:20082125
Biological Process	GO:0006508	proteolysis	IDE	IDA		Human	PMID:21185309
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	IDE	IDA		Human	PMID:9830016
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	Ide	IMP		Rat	PMID:15749695|RGD:1626704
Biological Process	GO:1903715	regulation of aerobic respiration	IDE	IGI	UniProtKB:P05067	Human	PMID:23525105
Biological Process	GO:0006979	response to oxidative stress	Ide	IDA		Mouse	PMID:26637123
Biological Process	GO:0003323	type B pancreatic cell development	ide	IMP	ZFIN:ZDB-MRPHLNO-160621-38	Zfish	PMID:26963759
Biological Process	GO:0010992	ubiquitin recycling	IDE	IDA		Human	PMID:21185309

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern