Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IDH1
  • Mouse genes Idh1
  • Rat genes Idh1
  • Zfish genes idh1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Idh1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	IDH1	HDA		Human	PMID:25468996
Molecular Function	GO:0042802	identical protein binding	IDH1	IPI	UniProtKB:O75874	Human	PMID:19935646
Molecular Function	GO:0042802	identical protein binding	IDH1	IPI	UniProtKB:O75874	Human	PMID:21516116
Molecular Function	GO:0042802	identical protein binding	IDH1	IPI	UniProtKB:O75874	Human	PMID:26436839
Molecular Function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	IDH1	IDA		Human	PMID:10521434
Molecular Function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	IDH1	IDA		Human	PMID:19935646
Molecular Function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	IDH1	IDA		Human	PMID:20171178
Molecular Function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	Idh1	IDA		Mouse	PMID:1914521
Molecular Function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	Idh1	IDA		Mouse	PMID:12031902
Molecular Function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	Idh1	IDA		Mouse	PMID:1180875
Molecular Function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	Idh1	IDA		Mouse	PMID:18275837
Molecular Function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	Idh1	IDA		Rat	PMID:17447164|RGD:1624966
Molecular Function	GO:0000287	magnesium ion binding	IDH1	IDA		Human	PMID:19935646
Molecular Function	GO:0050661	NADP binding	Idh1	IDA		Rat	PMID:17447164|RGD:1624966
Molecular Function	GO:0005515	protein binding	IDH1	IPI	UniProtKB:P0DP23	Human	PMID:31983428
Molecular Function	GO:0005515	protein binding	IDH1	IPI	UniProtKB:P16284	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IDH1	IPI	UniProtKB:P17612	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IDH1	IPI	UniProtKB:P27797	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IDH1	IPI	UniProtKB:P36957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IDH1	IPI	UniProtKB:P37173	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IDH1	IPI	UniProtKB:P50454	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IDH1	IPI	UniProtKB:Q05086-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IDH1	IPI	UniProtKB:Q8TDX7	Human	PMID:32814053
Molecular Function	GO:0042803	protein homodimerization activity	IDH1	IPI	UniProtKB:O75874	Human	PMID:19935646
Cellular Component	GO:0005737	cytoplasm	IDH1	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005829	cytosol	IDH1	IDA		Human	PMID:10521434
Cellular Component	GO:0005829	cytosol	Idh1	IDA		Mouse	PMID:12031902
Cellular Component	GO:0070062	extracellular exosome	IDH1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	IDH1	HDA		Human	PMID:23533145
Cellular Component	GO:0005739	mitochondrion	Idh1	IDA		Mouse	PMID:18275837
Cellular Component	GO:0005739	mitochondrion	Idh1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005777	peroxisome	IDH1	IDA		Human	PMID:10521434
Cellular Component	GO:0005777	peroxisome	Idh1	IDA		Rat	PMID:14561759|RGD:1580664
Biological Process	GO:0006103	2-oxoglutarate metabolic process	IDH1	IDA		Human	PMID:19935646
Biological Process	GO:0008585	female gonad development	Idh1	IEP		Rat	PMID:8083215|RGD:633072
Biological Process	GO:0006749	glutathione metabolic process	Idh1	IMP		Mouse	PMID:12031902
Biological Process	GO:0030097	hemopoiesis	idh1	IMP	ZFIN:ZDB-TALEN-150806-1	Zfish	PMID:25778530
Biological Process	GO:0030097	hemopoiesis	idh1	IMP	ZFIN:ZDB-MRPHLNO-150806-1	Zfish	PMID:25778530
Biological Process	GO:0006102	isocitrate metabolic process	IDH1	IDA		Human	PMID:10521434
Biological Process	GO:0006102	isocitrate metabolic process	IDH1	IDA		Human	PMID:19935646
Biological Process	GO:0006102	isocitrate metabolic process	IDH1	IDA		Human	PMID:20171178
Biological Process	GO:0006102	isocitrate metabolic process	Idh1	IDA		Rat	PMID:17447164|RGD:1624966
Biological Process	GO:0071071	regulation of phospholipid biosynthetic process	Idh1	IMP		Mouse	PMID:25218477
Biological Process	GO:0060696	regulation of phospholipid catabolic process	Idh1	IMP		Mouse	PMID:25218477
Biological Process	GO:0014070	response to organic cyclic compound	Idh1	IDA		Rat	PMID:8486157|RGD:1626477
Biological Process	GO:0006979	response to oxidative stress	Idh1	IDA		Mouse	PMID:12031902
Biological Process	GO:0048545	response to steroid hormone	Idh1	IDA		Rat	PMID:8349575|RGD:1626476

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern