Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IDH3A
  • Mouse genes Idh3a
  • Rat genes Idh3a
  • Zfish genes idh3a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Idh3a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004449	isocitrate dehydrogenase (NAD+) activity	IDH3A	IDA		Human	PMID:28098230
Molecular Function	GO:0004449	isocitrate dehydrogenase (NAD+) activity	Idh3a	IDA		Rat	PMID:11237704|RGD:70770
Molecular Function	GO:0004449	isocitrate dehydrogenase (NAD+) activity	Idh3a	IDA		Rat	PMID:938457|RGD:2306828
Molecular Function	GO:0000287	magnesium ion binding	IDH3A	IDA		Human	PMID:28098230
Molecular Function	GO:0005515	protein binding	IDH3A	IPI	UniProtKB:P51553	Human	PMID:14555658
Molecular Function	GO:0005515	protein binding	IDH3A	IPI	UniProtKB:P51553	Human	PMID:28098230
Molecular Function	GO:0005515	protein binding	IDH3A	IPI	UniProtKB:P51553	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	IDH3A	IPI	UniProtKB:P34896	Human	PMID:30613765
Cellular Component	GO:0005962	mitochondrial isocitrate dehydrogenase complex (NAD+)	IDH3A	IPI		Human	PMID:14555658
Cellular Component	GO:0005739	mitochondrion	IDH3A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Idh3a	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Idh3a	HDA		Mouse	PMID:18614015
Cellular Component	GO:0043209	myelin sheath	Idh3a	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005634	nucleus	IDH3A	HDA		Human	PMID:21630459
Biological Process	GO:0006103	2-oxoglutarate metabolic process	Idh3a	IDA		Rat	PMID:938457|RGD:2306828
Biological Process	GO:0006102	isocitrate metabolic process	Idh3a	IDA		Rat	PMID:938457|RGD:2306828
Biological Process	GO:0006734	NADH metabolic process	Idh3a	IDA		Rat	PMID:938457|RGD:2306828
Biological Process	GO:0006099	tricarboxylic acid cycle	IDH3A	IDA		Human	PMID:14555658
Biological Process	GO:0006099	tricarboxylic acid cycle	Idh3a	IDA		Rat	PMID:938457|RGD:2306828

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern