Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IDS
  • Mouse genes Ids
  • Rat genes Ids
  • Zfish genes ids
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ids

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	IDS	IDA		Human	PMID:28593992
Molecular Function	GO:0004423	iduronate-2-sulfatase activity	IDS	IDA		Human	PMID:10838181
Molecular Function	GO:0004423	iduronate-2-sulfatase activity	Ids	IMP	MGI:MGI:3625122	Mouse	PMID:12572850
Molecular Function	GO:0004423	iduronate-2-sulfatase activity	Ids	IMP	MGI:MGI:3625122	Mouse	PMID:17876721
Molecular Function	GO:0004423	iduronate-2-sulfatase activity	Ids	IMP	MGI:MGI:5439833	Mouse	PMID:22704483
Molecular Function	GO:0004423	iduronate-2-sulfatase activity	ids	IDA		Zfish	PMID:19761845
Molecular Function	GO:0005515	protein binding	IDS	IPI	UniProtKB:Q8NBJ7	Human	PMID:15962010
Molecular Function	GO:0005515	protein binding	Ids	IPI	PR:Q8BPG6	Mouse	PMID:15962010
Molecular Function	GO:0008484	sulfuric ester hydrolase activity	Ids	IDA		Mouse	PMID:15962010
Cellular Component	GO:0005737	cytoplasm	ids	IDA		Zfish	PMID:19761845
Cellular Component	GO:0043202	lysosomal lumen	Ids	IDA		Mouse	PMID:17876721
Cellular Component	GO:0005764	lysosome	IDS	IDA		Human	PMID:10838181
Cellular Component	GO:0005764	lysosome	Ids	IDA		Mouse	MGI:MGI:6368061|PMID:15149955
Cellular Component	GO:0005764	lysosome	Ids	IMP	MGI:MGI:3625122	Mouse	PMID:16505002
Biological Process	GO:0060348	bone development	ids	IMP	ZFIN:ZDB-GENO-191115-1	Zfish	PMID:29648648
Biological Process	GO:0061316	canonical Wnt signaling pathway involved in heart development	ids	IMP	ZFIN:ZDB-MRPHLNO-100422-6	Zfish	PMID:28334757
Biological Process	GO:0060536	cartilage morphogenesis	ids	IMP	ZFIN:ZDB-MRPHLNO-100422-6	Zfish	PMID:19761845
Biological Process	GO:0043009	chordate embryonic development	ids	IMP	ZFIN:ZDB-MRPHLNO-100422-6	Zfish	PMID:19761845
Biological Process	GO:0030209	dermatan sulfate catabolic process	Ids	IMP	MGI:MGI:5439833	Mouse	PMID:30064964
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	ids	IMP	ZFIN:ZDB-MRPHLNO-100422-6	Zfish	PMID:33096603
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	ids	IMP	ZFIN:ZDB-GENO-191115-1	Zfish	PMID:29648648
Biological Process	GO:0006027	glycosaminoglycan catabolic process	IDS	IDA		Human	PMID:28593992
Biological Process	GO:0060347	heart trabecula formation	ids	IMP	ZFIN:ZDB-MRPHLNO-100422-6	Zfish	PMID:28334757
Biological Process	GO:0030200	heparan sulfate proteoglycan catabolic process	Ids	IMP	MGI:MGI:3625122	Mouse	PMID:17876721
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ids	IMP	ZFIN:ZDB-MRPHLNO-100422-6	Zfish	PMID:19761845
Biological Process	GO:0007224	smoothened signaling pathway	ids	IMP	ZFIN:ZDB-MRPHLNO-100422-6	Zfish	PMID:28334757

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern