Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IFI16,MNDA,PYHIN1
  • Mouse genes Ifi204
  • Rat genes Mnda
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ifi204

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003690	double-stranded DNA binding	IFI16	IDA		Human	PMID:7536752
Molecular Function	GO:0003690	double-stranded DNA binding	Ifi204	IDA		Mouse	PMID:19158679
Molecular Function	GO:0005515	protein binding	MNDA	IPI	UniProtKB:Q9BZ95	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	MNDA	IPI	UniProtKB:O14656-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MNDA	IPI	UniProtKB:O43933	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MNDA	IPI	UniProtKB:P01023	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MNDA	IPI	UniProtKB:P02766	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MNDA	IPI	UniProtKB:P08581	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MNDA	IPI	UniProtKB:P28799	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MNDA	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MNDA	IPI	UniProtKB:P49810	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MNDA	IPI	UniProtKB:P49821	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MNDA	IPI	UniProtKB:P50570-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MNDA	IPI	UniProtKB:P61981	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MNDA	IPI	UniProtKB:Q15047-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MNDA	IPI	UniProtKB:Q8TAP4-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MNDA	IPI	UniProtKB:Q92993	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IFI16	IPI	UniProtKB:P38398	Human	PMID:14654789
Molecular Function	GO:0005515	protein binding	IFI16	IPI	UniProtKB:P10275	Human	PMID:16494870
Molecular Function	GO:0005515	protein binding	IFI16	IPI	UniProtKB:Q86WV6	Human	PMID:20890285
Molecular Function	GO:0005515	protein binding	IFI16	IPI	UniProtKB:Q13330	Human	PMID:24413532
Molecular Function	GO:0005515	protein binding	IFI16	IPI	UniProtKB:W6CW81	Human	PMID:24531343
Molecular Function	GO:0005515	protein binding	IFI16	IPI	UniProtKB:Q96C10	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	Ifi204	IPI	UniProtKB:F6ZDS4	Mouse	MGI:MGI:5487541|PMID:12513910
Molecular Function	GO:0005515	protein binding	Ifi204	IPI	PR:Q08775	Mouse	PMID:15557274
Molecular Function	GO:0003723	RNA binding	IFI16	HDA		Human	PMID:22658674
Molecular Function	GO:0003712	transcription coregulator activity	Ifi204	IGI	MGI:MGI:88177	Mouse	PMID:15557274
Molecular Function	GO:0008134	transcription factor binding	IFI16	IDA		Human	PMID:12894224
Molecular Function	GO:0008134	transcription factor binding	IFI16	IDA		Human	PMID:22291595
Molecular Function	GO:0031625	ubiquitin protein ligase binding	PYHIN1	IPI	UniProtKB:Q00987	Human	PMID:16479015
Cellular Component	GO:0005829	cytosol	MNDA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	IFI16	IPI	UniProtKB:W6CW81	Human	PMID:24531343
Cellular Component	GO:0005829	cytosol	IFI16	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	MNDA	HDA		Human	PMID:19056867
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	MNDA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	IFI16	HDA		Human	PMID:19946888
Cellular Component	GO:0042405	nuclear inclusion body	Ifi204	IDA		Mouse	MGI:MGI:5487541|PMID:12513910
Cellular Component	GO:0016607	nuclear speck	IFI16	IDA		Human	PMID:19158679
Cellular Component	GO:0005730	nucleolus	MNDA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	IFI16	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	IFI16	IDA		Human	PMID:14654789
Cellular Component	GO:0005730	nucleolus	PYHIN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	Ifi204	IDA		Mouse	MGI:MGI:5487541|PMID:12513910
Cellular Component	GO:0005654	nucleoplasm	MNDA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	IFI16	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	IFI16	IDA		Human	PMID:14654789
Cellular Component	GO:0005654	nucleoplasm	PYHIN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	IFI16	IDA		Human	PMID:19158679
Cellular Component	GO:0005634	nucleus	IFI16	IDA		Human	PMID:24413532
Cellular Component	GO:0005634	nucleus	IFI16	IDA		Human	PMID:24531343
Cellular Component	GO:0005634	nucleus	IFI16	IDA		Human	PMID:7536752
Cellular Component	GO:0032991	protein-containing complex	PYHIN1	IMP		Human	PMID:16479015
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	IFI16	IMP		Human	PMID:21575908
Biological Process	GO:0002218	activation of innate immune response	IFI16	IDA		Human	PMID:21575908
Biological Process	GO:0050853	B cell receptor signaling pathway	MNDA	IMP		Human	PMID:17875758
Biological Process	GO:0042149	cellular response to glucose starvation	IFI16	IDA		Human	PMID:21573174
Biological Process	GO:0035457	cellular response to interferon-alpha	PYHIN1	IMP		Human	PMID:16479015
Biological Process	GO:0035457	cellular response to interferon-alpha	Ifi204	IDA		Mouse	MGI:MGI:5487541|PMID:12513910
Biological Process	GO:0035458	cellular response to interferon-beta	Ifi204	IDA		Mouse	PMID:19158679
Biological Process	GO:0071479	cellular response to ionizing radiation	IFI16	IDA		Human	PMID:14654789
Biological Process	GO:0051607	defense response to virus	IFI16	IDA		Human	PMID:21478870
Biological Process	GO:0051607	defense response to virus	IFI16	IMP		Human	PMID:21575908
Biological Process	GO:0006974	DNA damage response	MNDA	IMP		Human	PMID:17875758
Biological Process	GO:0040029	epigenetic regulation of gene expression	IFI16	IMP		Human	PMID:24413532
Biological Process	GO:0048839	inner ear development	Ifi204	IDA		Mouse	PMID:21795542
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	IFI16	IMP		Human	PMID:21573174
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IFI16	IDA		Human	PMID:14654789
Biological Process	GO:0030224	monocyte differentiation	IFI16	IDA		Human	PMID:9766636
Biological Process	GO:0030889	negative regulation of B cell proliferation	MNDA	IMP		Human	PMID:17875758
Biological Process	GO:2000117	negative regulation of cysteine-type endopeptidase activity	IFI16	IDA		Human	PMID:22046441
Biological Process	GO:0043392	negative regulation of DNA binding	IFI16	IDA		Human	PMID:22291595
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IFI16	IDA		Human	PMID:9642285
Biological Process	GO:0045824	negative regulation of innate immune response	IFI16	IDA		Human	PMID:22046441
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IFI16	IDA		Human	PMID:12894224
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IFI16	IMP		Human	PMID:22046441
Biological Process	GO:0045071	negative regulation of viral genome replication	IFI16	IDA		Human	PMID:22291595
Biological Process	GO:0043065	positive regulation of apoptotic process	MNDA	IMP		Human	PMID:17875758
Biological Process	GO:0043388	positive regulation of DNA binding	PYHIN1	IDA		Human	PMID:16479015
Biological Process	GO:1902164	positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	PYHIN1	IDA		Human	PMID:16479015
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	PYHIN1	IDA		Human	PMID:16479015
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	PYHIN1	IDA		Human	PMID:18247378
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IFI16	IDA		Human	PMID:21575908
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Ifi204	IGI	MGI:MGI:88177	Mouse	PMID:15557274
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	PYHIN1	IDA		Human	PMID:16479015
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IFI16	IDA		Human	PMID:11146555
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IFI16	IMP		Human	PMID:21575908
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	PYHIN1	IMP		Human	PMID:16479015
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	PYHIN1	IDA		Human	PMID:18247378
Biological Process	GO:0031648	protein destabilization	PYHIN1	IMP		Human	PMID:16479015
Biological Process	GO:0031648	protein destabilization	PYHIN1	IMP		Human	PMID:18247378
Biological Process	GO:0050821	protein stabilization	PYHIN1	IMP		Human	PMID:16479015
Biological Process	GO:0010506	regulation of autophagy	IFI16	IEP		Human	PMID:21573174
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Ifi204	IDA		Mouse	PMID:15557274
Biological Process	GO:0009617	response to bacterium	Ifi204	IEP		Mouse	PMID:23012479

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern