Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IFIH1
  • Mouse genes Ifih1
  • Rat genes Ifih1
  • Zfish genes ifih1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ifih1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032559	adenyl ribonucleotide binding	IFIH1	IDA		Human	PMID:23090998
Molecular Function	GO:0032559	adenyl ribonucleotide binding	IFIH1	IDA		Human	PMID:30449722
Molecular Function	GO:0016887	ATP hydrolysis activity	IFIH1	IMP		Human	PMID:19211564
Molecular Function	GO:0003725	double-stranded RNA binding	IFIH1	IDA		Human	PMID:19656871
Molecular Function	GO:0003725	double-stranded RNA binding	IFIH1	IDA		Human	PMID:23090998
Molecular Function	GO:0003725	double-stranded RNA binding	IFIH1	IDA		Human	PMID:30449722
Molecular Function	GO:0042802	identical protein binding	IFIH1	IPI	UniProtKB:Q9BYX4	Human	PMID:22160685
Molecular Function	GO:0042802	identical protein binding	IFIH1	IDA		Human	PMID:23090998
Molecular Function	GO:0042802	identical protein binding	IFIH1	IPI	UniProtKB:Q9BYX4	Human	PMID:25865883
Molecular Function	GO:0042802	identical protein binding	IFIH1	IDA		Human	PMID:30449722
Molecular Function	GO:0042802	identical protein binding	IFIH1	IDA		Human	PMID:33727702
Molecular Function	GO:0038187	pattern recognition receptor activity	IFIH1	IDA		Human	PMID:21217758
Molecular Function	GO:0038187	pattern recognition receptor activity	IFIH1	IDA		Human	PMID:23273991
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q7Z434	Human	PMID:16127453
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q96EQ8	Human	PMID:17460044
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q14164	Human	PMID:17600090
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q14164|UniProtKB:Q3LXA3|UniProtKB:Q7Z434	Human	PMID:17600090
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q3LXA3	Human	PMID:17600090
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q7Z434-1	Human	PMID:17600090
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:P11207	Human	PMID:19403670
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:P30927	Human	PMID:19403670
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q9EMA9	Human	PMID:19403670
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q7Z434-1	Human	PMID:19416887
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q86WI3	Human	PMID:20434986
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:O75928	Human	PMID:21156324
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q8IY21	Human	PMID:21791617
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q7Z434	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:P04487	Human	PMID:22301138
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q7Z434	Human	PMID:22301138
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:O75179	Human	PMID:22328336
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q7Z434	Human	PMID:22623778
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:O43657	Human	PMID:22908223
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:P0C774	Human	PMID:23328395
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:P11207	Human	PMID:23328395
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:O14730	Human	PMID:25865883
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:O75569	Human	PMID:28591694
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q9NUD5	Human	PMID:30193849
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q14145	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:P0DTC5	Human	PMID:33372174
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:Q7Z434	Human	PMID:33372174
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:P05161	Human	PMID:33727702
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:P0C774	Human	PMID:33727702
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:P0DTD1:PRO_0000449621	Human	PMID:33727702
Molecular Function	GO:0005515	protein binding	IFIH1	IPI	UniProtKB:P0DTC5	Human	PMID:34084167
Molecular Function	GO:0005515	protein binding	Ifih1	IPI	UniProtKB:P11207	Mouse	MGI:MGI:5468372|PMID:23328395
Molecular Function	GO:0005515	protein binding	Ifih1	IPI	UniProtKB:E9PZQ1	Mouse	PMID:21791617
Molecular Function	GO:0005515	protein binding	ifih1	IPI	ZFIN:ZDB-GENE-061108-4	Zfish	PMID:27235368
Molecular Function	GO:0046982	protein heterodimerization activity	ifih1	IPI	ZFIN:ZDB-GENE-070112-1402	Zfish	PMID:24116956
Molecular Function	GO:0035639	purine ribonucleoside triphosphate binding	IFIH1	IDA		Human	PMID:23090998
Molecular Function	GO:0035639	purine ribonucleoside triphosphate binding	IFIH1	IDA		Human	PMID:30449722
Molecular Function	GO:0043021	ribonucleoprotein complex binding	IFIH1	IPI	UniProtKB:Q15366	Human	PMID:19881509
Molecular Function	GO:0003723	RNA binding	IFIH1	IDA		Human	PMID:33727702
Molecular Function	GO:0003724	RNA helicase activity	IFIH1	IMP		Human	PMID:19211564
Molecular Function	GO:0003727	single-stranded RNA binding	IFIH1	IDA		Human	PMID:19656871
Molecular Function	GO:0008270	zinc ion binding	IFIH1	IDA		Human	PMID:19380577
Molecular Function	GO:0008270	zinc ion binding	IFIH1	IDA		Human	PMID:19531363
Cellular Component	GO:0005737	cytoplasm	IFIH1	IDA		Human	PMID:11805321
Cellular Component	GO:0005737	cytoplasm	IFIH1	IDA		Human	PMID:33727702
Cellular Component	GO:0005737	cytoplasm	Ifih1	IDA		Mouse	PMID:28031478
Cellular Component	GO:0005739	mitochondrion	IFIH1	IDA		Human	PMID:33727702
Biological Process	GO:0140374	antiviral innate immune response	Ifih1	IMP	MGI:MGI:3663677	Mouse	PMID:28031478
Biological Process	GO:0071360	cellular response to exogenous dsRNA	IFIH1	IMP		Human	PMID:21957149
Biological Process	GO:0098586	cellular response to virus	IFIH1	IEP		Human	PMID:28146100
Biological Process	GO:0051607	defense response to virus	IFIH1	IDA		Human	PMID:21478870
Biological Process	GO:0051607	defense response to virus	IFIH1	IDA		Human	PMID:33727702
Biological Process	GO:0045087	innate immune response	Ifih1	IMP		Mouse	MGI:MGI:5318026|PMID:17942531
Biological Process	GO:0032608	interferon-beta production	Ifih1	IMP	MGI:MGI:3663677	Mouse	PMID:28031478
Biological Process	GO:0039530	MDA-5 signaling pathway	IFIH1	IDA		Human	PMID:17600090
Biological Process	GO:0039530	MDA-5 signaling pathway	IFIH1	IMP		Human	PMID:19211564
Biological Process	GO:0039530	MDA-5 signaling pathway	IFIH1	IDA		Human	PMID:33727702
Biological Process	GO:0045071	negative regulation of viral genome replication	IFIH1	IDA		Human	PMID:33727702
Biological Process	GO:0032727	positive regulation of interferon-alpha production	IFIH1	IMP		Human	PMID:19656871
Biological Process	GO:0032727	positive regulation of interferon-alpha production	IFIH1	IMP		Human	PMID:21957149
Biological Process	GO:0032728	positive regulation of interferon-beta production	IFIH1	IDA		Human	PMID:17600090
Biological Process	GO:0032728	positive regulation of interferon-beta production	IFIH1	IMP		Human	PMID:19656871
Biological Process	GO:0032728	positive regulation of interferon-beta production	IFIH1	IMP		Human	PMID:21957149
Biological Process	GO:0032728	positive regulation of interferon-beta production	IFIH1	IDA		Human	PMID:33727702
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IFIH1	IMP		Human	PMID:21957149
Biological Process	GO:0060760	positive regulation of response to cytokine stimulus	IFIH1	IMP		Human	PMID:21957149
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IFIH1	IMP		Human	PMID:21957149
Biological Process	GO:0051259	protein complex oligomerization	Ifih1	IDA		Mouse	PMID:28031478
Biological Process	GO:0016925	protein sumoylation	IFIH1	IDA		Human	PMID:21156324
Biological Process	GO:0006355	regulation of DNA-templated transcription	ifih1	IGI	ZFIN:ZDB-GENE-070112-1402	Zfish	PMID:24116956
Biological Process	GO:0006355	regulation of DNA-templated transcription	ifih1	IDA		Zfish	PMID:24116956
Biological Process	GO:0009615	response to virus	IFIH1	IDA		Human	PMID:33727702
Biological Process	GO:0009615	response to virus	Ifih1	IMP		Mouse	MGI:MGI:5318026|PMID:17942531
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	Ifih1	IMP	MGI:MGI:3663677	Mouse	PMID:28031478

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern