Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IFIT1,IFIT1B
  • Mouse genes Ifit1
  • Rat genes Ifit1
  • Zfish genes ifit10,ifit11,ifit12,ifit8,ifit9
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ifit1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	IFIT1	IPI	UniProtKB:O14879	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	IFIT1	IPI	UniProtKB:P04014	Human	PMID:19008854
Molecular Function	GO:0005515	protein binding	IFIT1	IPI	UniProtKB:P06789	Human	PMID:19008854
Molecular Function	GO:0005515	protein binding	IFIT1	IPI	UniProtKB:P17382	Human	PMID:19008854
Molecular Function	GO:0005515	protein binding	IFIT1	IPI	UniProtKB:Q86WV6	Human	PMID:19416887
Molecular Function	GO:0005515	protein binding	IFIT1	IPI	UniProtKB:P09913	Human	PMID:21190939
Molecular Function	GO:0005515	protein binding	IFIT1	IPI	UniProtKB:P61313	Human	PMID:21612406
Molecular Function	GO:0005515	protein binding	IFIT1	IPI	UniProtKB:O14879	Human	PMID:21642987
Molecular Function	GO:0005515	protein binding	IFIT1	IPI	UniProtKB:P09913	Human	PMID:21642987
Molecular Function	GO:0005515	protein binding	IFIT1	IPI	UniProtKB:O14879	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	IFIT1	IPI	UniProtKB:O14879	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	IFIT1	IPI	UniProtKB:P09913	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	IFIT1	IPI	UniProtKB:O14879	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	IFIT1	IPI	UniProtKB:O14879	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	IFIT1B	IPI	UniProtKB:O14879	Human	PMID:21642987
Molecular Function	GO:0005515	protein binding	IFIT1B	IPI	UniProtKB:O14879	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Ifit1	IPI	UniProtKB:P10126	Mouse	MGI:MGI:5465530|PMID:19856081
Molecular Function	GO:0003723	RNA binding	IFIT1	IDA		Human	PMID:21642987
Cellular Component	GO:0005737	cytoplasm	IFIT1	IDA		Human	PMID:19008854
Cellular Component	GO:0005737	cytoplasm	IFIT1	IDA		Human	PMID:21642987
Cellular Component	GO:0005737	cytoplasm	Ifit1	IDA		Mouse	MGI:MGI:5465530|PMID:19856081
Cellular Component	GO:0005829	cytosol	IFIT1	IDA		Human	GO_REF:0000052
Biological Process	GO:0140374	antiviral innate immune response	IFIT1	IEP		Human	PMID:25930096
Biological Process	GO:0071360	cellular response to exogenous dsRNA	IFIT1	IDA		Human	PMID:19008854
Biological Process	GO:0035457	cellular response to interferon-alpha	Ifit1	IDA		Mouse	PMID:7896268
Biological Process	GO:0035458	cellular response to interferon-beta	Ifit1	IDA		Mouse	PMID:19158679
Biological Process	GO:0071357	cellular response to type I interferon	IFIT1	IDA		Human	PMID:19008854
Biological Process	GO:0051607	defense response to virus	ifit10	IDA		Zfish	PMID:24950240
Biological Process	GO:0019060	intracellular transport of viral protein in host cell	IFIT1	IDA		Human	PMID:19008854
Biological Process	GO:0051097	negative regulation of helicase activity	IFIT1	IDA		Human	PMID:19008854
Biological Process	GO:0032091	negative regulation of protein binding	IFIT1	IDA		Human	PMID:19416887
Biological Process	GO:0045071	negative regulation of viral genome replication	IFIT1	IMP		Human	PMID:19008854
Biological Process	GO:0045071	negative regulation of viral genome replication	IFIT1	IMP		Human	PMID:21976647
Biological Process	GO:0045070	positive regulation of viral genome replication	IFIT1	IDA		Human	PMID:19416887
Biological Process	GO:0009617	response to bacterium	Ifit1	IEP		Mouse	PMID:23012479
Biological Process	GO:0009615	response to virus	IFIT1	IDA		Human	PMID:19416887
Biological Process	GO:0009615	response to virus	IFIT1	IMP		Human	PMID:21642987
Biological Process	GO:0009615	response to virus	Ifit1	IMP		Mouse	MGI:MGI:5437423|PMID:21085181
Biological Process	GO:0009615	response to virus	Ifit1	IMP		Mouse	MGI:MGI:5437411|PMID:21642987

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern