Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IFITM2,IFITM3
  • Mouse genes Ifitm2
  • Rat genes Ifitm2
  • Zfish genes ifitm1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ifitm2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:P43490	Human	PMID:18486613
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:O95415	Human	PMID:30983867
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:O15552	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:O60669	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:O95470	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:O95870	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:P19397	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:P35372-10	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:P43628	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:P60201-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:Q12908	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:Q14973	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:Q6UWN5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:Q86VR2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:Q8N661	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:Q96HJ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:Q96KR6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:Q9H6H4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:Q9NXB9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:Q9NZD1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:Q9Y282	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFITM3	IPI	UniProtKB:Q9Y680	Human	PMID:32296183
Cellular Component	GO:0030054	cell junction	IFITM2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031901	early endosome membrane	IFITM3	IDA		Human	PMID:26354436
Cellular Component	GO:0031902	late endosome membrane	IFITM2	IDA		Human	PMID:26354436
Cellular Component	GO:0005765	lysosomal membrane	IFITM3	IDA		Human	PMID:26354436
Cellular Component	GO:0005765	lysosomal membrane	IFITM2	IDA		Human	PMID:26354436
Cellular Component	GO:0005654	nucleoplasm	IFITM2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	IFITM3	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005886	plasma membrane	IFITM3	IDA		Human	PMID:20943977
Cellular Component	GO:0032991	protein-containing complex	IFITM3	IDA		Human	PMID:28246125
Cellular Component	GO:0032991	protein-containing complex	IFITM2	IDA		Human	PMID:28246125
Biological Process	GO:0035458	cellular response to interferon-beta	IFITM2	IDA		Human	PMID:33563656
Biological Process	GO:0051607	defense response to virus	IFITM3	IDA		Human	PMID:21478870
Biological Process	GO:0051607	defense response to virus	Ifitm2	IDA		Mouse	PMID:20064371
Biological Process	GO:0007507	heart development	Ifitm2	IEP		Rat	PMID:22021094|RGD:7495752
Biological Process	GO:0046597	negative regulation of viral entry into host cell	IFITM3	IDA		Human	PMID:20943977
Biological Process	GO:0046597	negative regulation of viral entry into host cell	IFITM3	IDA		Human	PMID:21253575
Biological Process	GO:0046597	negative regulation of viral entry into host cell	IFITM3	IMP		Human	PMID:23358889
Biological Process	GO:0046597	negative regulation of viral entry into host cell	IFITM3	IDA		Human	PMID:26354436
Biological Process	GO:0046597	negative regulation of viral entry into host cell	IFITM2	IDA		Human	PMID:21253575
Biological Process	GO:0046597	negative regulation of viral entry into host cell	IFITM2	IDA		Human	PMID:23358889
Biological Process	GO:0046597	negative regulation of viral entry into host cell	IFITM2	IDA		Human	PMID:26354436
Biological Process	GO:0046597	negative regulation of viral entry into host cell	IFITM2	IDA		Human	PMID:33563656
Biological Process	GO:0046597	negative regulation of viral entry into host cell	Ifitm2	IDA		Mouse	MGI:MGI:5437420|PMID:21253575
Biological Process	GO:0045071	negative regulation of viral genome replication	IFITM3	IDA		Human	PMID:20943977
Biological Process	GO:0045071	negative regulation of viral genome replication	IFITM3	IDA		Human	PMID:21253575
Biological Process	GO:0045071	negative regulation of viral genome replication	IFITM2	IDA		Human	PMID:21253575
Biological Process	GO:0032897	negative regulation of viral transcription	IFITM3	IDA		Human	PMID:20943977
Biological Process	GO:0035455	response to interferon-alpha	IFITM3	IDA		Human	PMID:22479637
Biological Process	GO:0035455	response to interferon-alpha	IFITM2	IDA		Human	PMID:22479637
Biological Process	GO:0035456	response to interferon-beta	IFITM3	IDA		Human	PMID:21253575
Biological Process	GO:0035456	response to interferon-beta	IFITM2	IDA		Human	PMID:21253575
Biological Process	GO:0034341	response to type II interferon	IFITM3	IDA		Human	PMID:21253575
Biological Process	GO:0034341	response to type II interferon	IFITM2	IDA		Human	PMID:21253575
Biological Process	GO:0009615	response to virus	IFITM3	IDA		Human	PMID:20943977
Biological Process	GO:0009615	response to virus	IFITM3	IDA		Human	PMID:21253575
Biological Process	GO:0009615	response to virus	IFITM3	IDA		Human	PMID:22479637
Biological Process	GO:0009615	response to virus	IFITM2	IDA		Human	PMID:20943977
Biological Process	GO:0009615	response to virus	IFITM2	IDA		Human	PMID:21253575
Biological Process	GO:0009615	response to virus	IFITM2	IDA		Human	PMID:22479637
Biological Process	GO:0009615	response to virus	Ifitm2	IDA		Mouse	MGI:MGI:5437420|PMID:21253575

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern