Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IFNA1,IFNA10,IFNA13,IFNA14,IFNA16,IFNA17,IFNA2,IFNA21,IFNA4,IFNA5,IFNA6,IFNA7,IFNA8
  • Mouse genes Ifna6
  • Rat genes Ifna11,Ifna16l1,Ifna2,Ifna4,Ifna5,LOC100912314,LOC100912356
  • Zfish genes ifnphi2,ifnphi3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ifna6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	IFNA2	IDA		Human	PMID:8082511
Molecular Function	GO:0005515	protein binding	IFNA1	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFNA2	IPI	UniProtKB:P48551	Human	PMID:21854986
Molecular Function	GO:0005515	protein binding	IFNA2	IPI	UniProtKB:Q9NPL8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFNA2	IPI	UniProtKB:P48551-3	Human	PMID:7759950
Molecular Function	GO:0005515	protein binding	IFNA14	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFNA6	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFNA4	IPI	UniProtKB:P04075-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	IFNA16	IPI	UniProtKB:O14964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFNA8	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Cellular Component	GO:0062023	collagen-containing extracellular matrix	IFNA2	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	IFNA2	HDA		Human	PMID:28675934
Cellular Component	GO:0005615	extracellular space	IFNA2	IDA		Human	PMID:8082511
Cellular Component	GO:0005615	extracellular space	Ifna6	IDA		Mouse	PMID:19130550
Biological Process	GO:0051607	defense response to virus	IFNA2	IDA		Human	PMID:22783022
Biological Process	GO:0051607	defense response to virus	Ifna6	IDA		Mouse	PMID:19130550
Biological Process	GO:0051607	defense response to virus	ifnphi2	IDA		Zfish	PMID:19265122
Biological Process	GO:0051607	defense response to virus	ifnphi2	IDA		Zfish	PMID:19717522
Biological Process	GO:0051607	defense response to virus	ifnphi3	IDA		Zfish	PMID:19265122
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IFNA2	IDA		Human	PMID:20554961
Biological Process	GO:0010629	negative regulation of gene expression	IFNA2	IDA		Human	PMID:20554961
Biological Process	GO:0032696	negative regulation of interleukin-13 production	IFNA2	IDA		Human	PMID:20554961
Biological Process	GO:0032714	negative regulation of interleukin-5 production	IFNA2	IDA		Human	PMID:20554961
Biological Process	GO:0045581	negative regulation of T cell differentiation	IFNA2	IDA		Human	PMID:20554961
Biological Process	GO:2000552	negative regulation of T-helper 2 cell cytokine production	IFNA2	IDA		Human	PMID:20554961
Biological Process	GO:0046597	negative regulation of viral entry into host cell	IFNA2	IDA		Human	PMID:22783022
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IFNA2	IDA		Human	PMID:22783022
Biological Process	GO:0009615	response to virus	ifnphi3	IDA		Zfish	PMID:27496972
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	IFNA2	IDA		Human	PMID:8082511

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern