Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IFNAR1
  • Mouse genes Ifnar1
  • Rat genes Ifnar1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ifnar1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019955	cytokine binding	IFNAR1	IPI	UniProtKB:P01574	Human	PMID:7813427
Molecular Function	GO:0004904	interferon receptor activity	Ifnar1	IMP		Mouse	MGI:MGI:5792628|PMID:27129230
Molecular Function	GO:0004904	interferon receptor activity	Ifnar1	IMP	MGI:MGI:1930950	Mouse	PMID:16139798
Molecular Function	GO:0008269	JAK pathway signal transduction adaptor activity	IFNAR1	IDA		Human	PMID:8605876
Molecular Function	GO:0005515	protein binding	IFNAR1	IPI	UniProtKB:P52630	Human	PMID:12220192
Molecular Function	GO:0005515	protein binding	IFNAR1	IPI	UniProtKB:Q9UKB1	Human	PMID:14532120
Molecular Function	GO:0005515	protein binding	IFNAR1	IPI	UniProtKB:Q86VI4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IFNAR1	IPI	UniProtKB:P48551	Human	PMID:7665574
Molecular Function	GO:0005515	protein binding	IFNAR1	IPI	UniProtKB:P52630	Human	PMID:8605876
Molecular Function	GO:0005515	protein binding	IFNAR1	IPI	UniProtKB:P42224	Human	PMID:9121453
Molecular Function	GO:0005515	protein binding	IFNAR1	IPI	UniProtKB:P52630	Human	PMID:9121453
Molecular Function	GO:0005515	protein binding	IFNAR1	IPI	UniProtKB:P52630	Human	PMID:9677371
Molecular Function	GO:0019962	type I interferon binding	Ifnar1	IPI	UniProtKB:P01575	Mouse	MGI:MGI:5562515|PMID:23872679
Molecular Function	GO:0004905	type I interferon receptor activity	IFNAR1	IDA		Human	PMID:21854986
Molecular Function	GO:0004905	type I interferon receptor activity	IFNAR1	IMP		Human	PMID:31270247
Molecular Function	GO:0004905	type I interferon receptor activity	IFNAR1	IMP		Human	PMID:33252644
Molecular Function	GO:0004905	type I interferon receptor activity	IFNAR1	IMP		Human	PMID:35442418
Molecular Function	GO:0004905	type I interferon receptor activity	IFNAR1	IDA		Human	PMID:7665574
Molecular Function	GO:0004905	type I interferon receptor activity	IFNAR1	IDA		Human	PMID:7813427
Molecular Function	GO:0004905	type I interferon receptor activity	Ifnar1	IDA		Mouse	MGI:MGI:5562515|PMID:23872679
Molecular Function	GO:0004905	type I interferon receptor activity	Ifnar1	IMP		Mouse	MGI:MGI:5705226|PMID:14532120
Cellular Component	GO:0005886	plasma membrane	IFNAR1	IDA		Human	PMID:14532120
Cellular Component	GO:0005886	plasma membrane	IFNAR1	IMP		Human	PMID:35442418
Cellular Component	GO:0005886	plasma membrane	Ifnar1	IDA		Mouse	MGI:MGI:5705226|PMID:14532120
Biological Process	GO:0035457	cellular response to interferon-alpha	Ifnar1	IMP		Mouse	MGI:MGI:5705226|PMID:14532120
Biological Process	GO:0035458	cellular response to interferon-beta	IFNAR1	IDA		Human	PMID:7813427
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Ifnar1	IMP		Rat	PMID:27999109|RGD:12910492
Biological Process	GO:0051607	defense response to virus	Ifnar1	IMP		Mouse	MGI:MGI:5792628|PMID:27129230
Biological Process	GO:0051607	defense response to virus	Ifnar1	IMP		Mouse	PMID:17277142
Biological Process	GO:0010467	gene expression	Ifnar1	IMP		Mouse	PMID:31623059
Biological Process	GO:1901857	positive regulation of cellular respiration	IFNAR1	IMP		Human	PMID:25930096
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Ifnar1	IMP		Mouse	MGI:MGI:5619426|PMID:24598055
Biological Process	GO:0032728	positive regulation of interferon-beta production	Ifnar1	IMP		Mouse	MGI:MGI:5619426|PMID:24598055
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Ifnar1	IMP		Mouse	PMID:23997220
Biological Process	GO:0032729	positive regulation of type II interferon production	Ifnar1	IGI	MGI:MGI:96242	Mouse	PMID:17164250
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IFNAR1	IDA		Human	PMID:7526154
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IFNAR1	IDA		Human	PMID:7657660
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IFNAR1	IDA		Human	PMID:7813427
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IFNAR1	IDA		Human	PMID:8605876
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	Ifnar1	IMP		Mouse	PMID:21606371
Biological Process	GO:0032496	response to lipopolysaccharide	Ifnar1	IMP		Mouse	MGI:MGI:5562515|PMID:23872679
Biological Process	GO:0042110	T cell activation	Ifnar1	IGI	MGI:MGI:96242	Mouse	PMID:17164250
Biological Process	GO:0032606	type I interferon production	Ifnar1	IMP		Mouse	PMID:15800576
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	IFNAR1	IDA		Human	PMID:21854986
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	IFNAR1	IDA		Human	PMID:7665574
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	Ifnar1	IMP		Mouse	MGI:MGI:5792628|PMID:27129230
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	Ifnar1	IDA		Mouse	MGI:MGI:5562515|PMID:23872679
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	Ifnar1	IMP		Mouse	MGI:MGI:5705226|PMID:14532120
Biological Process	GO:0032609	type II interferon production	Ifnar1	IGI	MGI:MGI:96242	Mouse	PMID:17164250

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern