Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IFNB1
  • Mouse genes Ifnb1
  • Rat genes Ifnb1
  • Zfish genes ifnphi1,ifnphi4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ifnb1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008811	chloramphenicol O-acetyltransferase activity	IFNB1	IMP		Human	PMID:19176627
Molecular Function	GO:0005125	cytokine activity	IFNB1	IDA		Human	PMID:10556041
Molecular Function	GO:0005125	cytokine activity	IFNB1	IDA		Human	PMID:19008854
Molecular Function	GO:0005125	cytokine activity	IFNB1	IDA		Human	PMID:6157094
Molecular Function	GO:0005125	cytokine activity	IFNB1	IDA		Human	PMID:7813427
Molecular Function	GO:0005125	cytokine activity	IFNB1	IDA		Human	PMID:8027027
Molecular Function	GO:0005125	cytokine activity	IFNB1	IDA		Human	PMID:8969169
Molecular Function	GO:0005125	cytokine activity	Ifnb1	IDA		Mouse	PMID:15240719
Molecular Function	GO:0005126	cytokine receptor binding	IFNB1	IDA		Human	PMID:10556041
Molecular Function	GO:0005126	cytokine receptor binding	IFNB1	IPI	UniProtKB:P17181	Human	PMID:7813427
Molecular Function	GO:0005126	cytokine receptor binding	IFNB1	IPI	UniProtKB:P48551	Human	PMID:8798579
Molecular Function	GO:0005126	cytokine receptor binding	IFNB1	IPI	UniProtKB:P48551	Human	PMID:8969169
Molecular Function	GO:0005515	protein binding	IFNB1	IPI	UniProtKB:P40855	Human	PMID:32296183
Molecular Function	GO:0005132	type I interferon receptor binding	Ifnb1	IPI	UniProtKB:P33896	Mouse	MGI:MGI:5562515|PMID:23872679
Cellular Component	GO:0005615	extracellular space	IFNB1	IDA		Human	PMID:21873635
Cellular Component	GO:0005615	extracellular space	IFNB1	IDA		Human	PMID:6157094
Cellular Component	GO:0005615	extracellular space	Ifnb1	IDA		Mouse	PMID:17277142
Biological Process	GO:0002250	adaptive immune response	Ifnb1	IDA		Mouse	PMID:17277142
Biological Process	GO:0002312	B cell activation involved in immune response	IFNB1	IMP		Human	PMID:12932356
Biological Process	GO:0042100	B cell proliferation	Ifnb1	IMP		Mouse	MGI:MGI:2680725|PMID:14597717
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Ifnb1	IDA		Mouse	PMID:21606371
Biological Process	GO:0071359	cellular response to dsRNA	Ifnb1	IEP		Mouse	MGI:MGI:3814787|PMID:18596219
Biological Process	GO:0035458	cellular response to interferon-beta	IFNB1	IDA		Human	PMID:18035482
Biological Process	GO:0035458	cellular response to interferon-beta	IFNB1	IDA		Human	PMID:7813427
Biological Process	GO:0035458	cellular response to interferon-beta	IFNB1	IDA		Human	PMID:8027027
Biological Process	GO:0035458	cellular response to interferon-beta	IFNB1	IDA		Human	PMID:8969169
Biological Process	GO:0098586	cellular response to virus	IFNB1	IEP		Human	PMID:28146100
Biological Process	GO:0098586	cellular response to virus	Ifnb1	IDA		Mouse	MGI:MGI:5645191|PMID:24882218
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IFNB1	IDA		Human	PMID:6157094
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IFNB1	IDA		Human	PMID:7813427
Biological Process	GO:0042742	defense response to bacterium	Ifnb1	IDA		Mouse	PMID:15240719
Biological Process	GO:0042742	defense response to bacterium	ifnphi1	IDA		Zfish	PMID:19265122
Biological Process	GO:0051607	defense response to virus	Ifnb1	IMP		Mouse	MGI:MGI:5792628|PMID:27129230
Biological Process	GO:0051607	defense response to virus	Ifnb1	IDA		Mouse	MGI:MGI:1354270|PMID:10708458
Biological Process	GO:0051607	defense response to virus	Ifnb1	IDA		Mouse	PMID:17277142
Biological Process	GO:0051607	defense response to virus	ifnphi1	IDA		Zfish	PMID:19717522
Biological Process	GO:0051607	defense response to virus	ifnphi1	IDA		Zfish	PMID:19265122
Biological Process	GO:0051607	defense response to virus	ifnphi1	IGI	ZFIN:ZDB-MRPHLNO-070906-3	Zfish	PMID:19717522
Biological Process	GO:0051607	defense response to virus	ifnphi1	IDA		Zfish	PMID:16704302
Biological Process	GO:0051607	defense response to virus	ifnphi4	IDA		Zfish	PMID:19717522
Biological Process	GO:0006959	humoral immune response	Ifnb1	IDA		Mouse	PMID:17277142
Biological Process	GO:0045087	innate immune response	IFNB1	IDA		Human	PMID:7813427
Biological Process	GO:0002281	macrophage activation involved in immune response	Ifnb1	IDA		Rat	PMID:10496312|RGD:12903242
Biological Process	GO:0140123	negative regulation of Lewy body formation	Ifnb1	IMP		Mouse	MGI:MGI:5695780|PMID:26451483
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	Ifnb1	IDA		Mouse	PMID:17442941
Biological Process	GO:0045581	negative regulation of T cell differentiation	IFNB1	IDA		Human	PMID:20554961
Biological Process	GO:2000552	negative regulation of T-helper 2 cell cytokine production	IFNB1	IDA		Human	PMID:20554961
Biological Process	GO:0045071	negative regulation of viral genome replication	IFNB1	IDA		Human	PMID:19008854
Biological Process	GO:0070050	neuron cellular homeostasis	Ifnb1	IMP		Mouse	MGI:MGI:5695780|PMID:26451483
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IFNB1	IDA		Human	PMID:10918594
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IFNB1	IDA		Human	PMID:11337497
Biological Process	GO:0010508	positive regulation of autophagy	Ifnb1	IMP		Mouse	MGI:MGI:5695780|PMID:26451483
Biological Process	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	IFNB1	IDA		Human	PMID:18035482
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IFNB1	IDA		Human	PMID:18035482
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IFNB1	IDA		Human	PMID:7813427
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IFNB1	IDA		Human	PMID:8027027
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IFNB1	IDA		Human	PMID:8798579
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IFNB1	IDA		Human	PMID:8969169
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IFNB1	IDA		Human	PMID:10556041
Biological Process	GO:0050691	regulation of defense response to virus by host	ifnphi1	IDA		Zfish	PMID:12525633
Biological Process	GO:0046685	response to arsenic-containing substance	ifnphi1	IDA		Zfish	PMID:16007375
Biological Process	GO:0046685	response to arsenic-containing substance	ifnphi1	IDA		Zfish	PMID:17400579
Biological Process	GO:0043330	response to exogenous dsRNA	IFNB1	IDA		Human	PMID:21266579
Biological Process	GO:0043330	response to exogenous dsRNA	ifnphi1	IDA		Zfish	PMID:19201835
Biological Process	GO:0043330	response to exogenous dsRNA	ifnphi1	IDA		Zfish	PMID:16225395
Biological Process	GO:0009615	response to virus	ifnphi1	IDA		Zfish	PMID:27496972
Biological Process	GO:0009615	response to virus	ifnphi1	IDA		Zfish	PMID:17400579
Biological Process	GO:0009615	response to virus	ifnphi1	IDA		Zfish	PMID:16007375
Biological Process	GO:0009615	response to virus	ifnphi1	IDA		Zfish	PMID:16777275
Biological Process	GO:0009615	response to virus	ifnphi1	IDA		Zfish	PMID:17371995
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	IFNB1	IDA		Human	PMID:18035482
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	Ifnb1	IMP		Mouse	MGI:MGI:5792628|PMID:27129230

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern