Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IFNL1,IFNL2,IFNL3
  • Mouse genes Ifnl3
  • Rat genes Ifnl1,Ifnl3
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ifnl3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032003	interleukin-28 receptor binding	IFNL1	IPI	UniProtKB:Q8IU57	Human	PMID:12469119
Molecular Function	GO:0005102	signaling receptor binding	IFNL1	IDA		Human	PMID:12483210
Cellular Component	GO:0005576	extracellular region	IFNL1	IDA		Human	PMID:12483210
Cellular Component	GO:0005615	extracellular space	Ifnl3	IDA		Mouse	PMID:16751416
Cellular Component	GO:0032002	interleukin-28 receptor complex	IFNL1	IDA		Human	PMID:12469119
Biological Process	GO:0051607	defense response to virus	IFNL1	IDA		Human	PMID:12469119
Biological Process	GO:0045087	innate immune response	Ifnl3	IDA		Mouse	PMID:16751416
Biological Process	GO:0008285	negative regulation of cell population proliferation	IFNL1	IDA		Human	PMID:15166220
Biological Process	GO:0008285	negative regulation of cell population proliferation	IFNL1	IDA		Human	PMID:15899585
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IFNL1	IDA		Human	PMID:19346497
Biological Process	GO:0032696	negative regulation of interleukin-13 production	IFNL1	IDA		Human	PMID:19346497
Biological Process	GO:0032714	negative regulation of interleukin-5 production	IFNL1	IDA		Human	PMID:19346497
Biological Process	GO:0043381	negative regulation of memory T cell differentiation	IFNL1	IDA		Human	PMID:19346497
Biological Process	GO:0045581	negative regulation of T cell differentiation	IFNL1	IDA		Human	PMID:19346497
Biological Process	GO:0002829	negative regulation of type 2 immune response	IFNL1	IDA		Human	PMID:19346497
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IFNL1	IDA		Human	PMID:12483210
Biological Process	GO:0045345	positive regulation of MHC class I biosynthetic process	IFNL1	IDA		Human	PMID:12483210
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IFNL1	IDA		Human	PMID:12483210
Biological Process	GO:0032729	positive regulation of type II interferon production	IFNL1	IDA		Human	PMID:19346497
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IFNL1	IDA		Human	PMID:15166220

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern