Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IFT122
  • Mouse genes Ift122
  • Rat genes Ift122
  • Zfish genes ift122
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ift122

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	IFT122	IPI	UniProtKB:Q9Q2G4	Human	PMID:22190034
Molecular Function	GO:0005515	protein binding	IFT122	IPI	UniProtKB:Q8NEZ3	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	IFT122	IPI	UniProtKB:Q8NEZ3	Human	PMID:27932497
Molecular Function	GO:0005515	protein binding	IFT122	IPI	UniProtKB:Q8NEZ3	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	IFT122	IPI	UniProtKB:Q8NEZ3,UniProtKB:Q96RY7|UniProtKB:Q96FT9,UniProtKB:Q9P2L0	Human	PMID:29220510
Molecular Function	GO:0005515	protein binding	IFT122	IPI	UniProtKB:Q86VG3	Human	PMID:30476139
Cellular Component	GO:0036064	ciliary basal body	IFT122	IDA		Human	PMID:29220510
Cellular Component	GO:0036064	ciliary basal body	Ift122	IDA		Mouse	MGI:MGI:4888042|PMID:21209331
Cellular Component	GO:0097546	ciliary base	Ift122	IDA		Mouse	MGI:MGI:4888042|PMID:21209331
Cellular Component	GO:0005929	cilium	IFT122	IDA		Human	PMID:29220510
Cellular Component	GO:0005929	cilium	Ift122	IDA		Mouse	MGI:MGI:4888042|PMID:21209331
Cellular Component	GO:0005737	cytoplasm	Ift122	IDA		Mouse	MGI:MGI:4888042|PMID:21209331
Cellular Component	GO:0030991	intraciliary transport particle A	IFT122	IPI		Human	PMID:27173435
Cellular Component	GO:0030991	intraciliary transport particle A	IFT122	IDA		Human	PMID:20889716
Cellular Component	GO:0030991	intraciliary transport particle A	IFT122	IDA		Human	PMID:27932497
Cellular Component	GO:0030991	intraciliary transport particle A	IFT122	IDA		Human	PMID:29220510
Cellular Component	GO:0030991	intraciliary transport particle A	IFT122	IDA		Human	PMID:30476139
Cellular Component	GO:0030991	intraciliary transport particle A	Ift122	IDA		Mouse	PMID:20889716
Cellular Component	GO:0016020	membrane	IFT122	HDA		Human	PMID:19946888
Cellular Component	GO:0032391	photoreceptor connecting cilium	Ift122	IDA		Mouse	MGI:MGI:3839506|PMID:19208653
Biological Process	GO:0048593	camera-type eye morphogenesis	Ift122	IMP		Mouse	MGI:MGI:3827087|PMID:19000668
Biological Process	GO:0048593	camera-type eye morphogenesis	ift122	IMP		Zfish	PMID:20493458|ZFIN:ZDB-PUB-100525-17
Biological Process	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway	Ift122	IGI	MGI:MGI:2443231	Mouse	PMID:22689656
Biological Process	GO:0060271	cilium assembly	IFT122	IMP		Human	PMID:29220510
Biological Process	GO:0060271	cilium assembly	Ift122	IMP		Mouse	MGI:MGI:3827087|PMID:19000668
Biological Process	GO:0060271	cilium assembly	Ift122	IMP	MGI:3578529	Mouse	PMID:28778798
Biological Process	GO:0060271	cilium assembly	Ift122	IGI	MGI:MGI:2443231	Mouse	PMID:22689656
Biological Process	GO:0060271	cilium assembly	Ift122	IMP	MGI:MGI:3578529	Mouse	PMID:22689656
Biological Process	GO:0060271	cilium assembly	ift122	IMP		Zfish	PMID:20493458|ZFIN:ZDB-PUB-100525-17
Biological Process	GO:0060271	cilium assembly	ift122	IMP	ZFIN:ZDB-GENO-170131-18	Zfish	PMID:27681595
Biological Process	GO:0060271	cilium assembly	ift122	IMP	ZFIN:ZDB-MRPHLNO-101228-1	Zfish	PMID:20493458
Biological Process	GO:0009953	dorsal/ventral pattern formation	Ift122	IMP	MGI:MGI:3578529	Mouse	PMID:15755804
Biological Process	GO:0009953	dorsal/ventral pattern formation	Ift122	IGI	MGI:MGI:98297	Mouse	PMID:21552265
Biological Process	GO:0010172	embryonic body morphogenesis	Ift122	IMP		Mouse	MGI:MGI:3827087|PMID:19000668
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	Ift122	IMP	MGI:3578529	Mouse	PMID:28778798
Biological Process	GO:0042733	embryonic digit morphogenesis	Ift122	IMP	MGI:MGI:3578529	Mouse	PMID:15755804
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Ift122	IMP		Mouse	MGI:MGI:4888042|PMID:21209331
Biological Process	GO:0035050	embryonic heart tube development	Ift122	IMP		Mouse	MGI:MGI:3827087|PMID:19000668
Biological Process	GO:0060971	embryonic heart tube left/right pattern formation	Ift122	IMP		Mouse	MGI:MGI:4888042|PMID:21209331
Biological Process	GO:0072594	establishment of protein localization to organelle	Ift122	IMP		Mouse	MGI:MGI:4888042|PMID:21209331
Biological Process	GO:0007507	heart development	ift122	IMP		Zfish	PMID:20493458|ZFIN:ZDB-PUB-100525-17
Biological Process	GO:0035720	intraciliary anterograde transport	Ift122	IMP		Mouse	MGI:MGI:4888042|PMID:21209331
Biological Process	GO:0035721	intraciliary retrograde transport	Ift122	IMP		Mouse	MGI:MGI:4888042|PMID:21209331
Biological Process	GO:0042073	intraciliary transport	IFT122	IMP		Human	PMID:29220510
Biological Process	GO:0043616	keratinocyte proliferation	Ift122	IMP		Mouse	PMID:21703454
Biological Process	GO:0060173	limb development	Ift122	IMP		Mouse	MGI:MGI:3827087|PMID:19000668
Biological Process	GO:0032402	melanosome transport	ift122	IMP	ZFIN:ZDB-MRPHLNO-180116-2	Zfish	PMID:24938409
Biological Process	GO:0001823	mesonephros development	ift122	IMP		Zfish	PMID:20493458|ZFIN:ZDB-PUB-100525-17
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	Ift122	IMP		Mouse	PMID:21703454
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Ift122	IMP		Mouse	MGI:MGI:4888042|PMID:21209331
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Ift122	IMP	MGI:3578529	Mouse	PMID:28778798
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Ift122	IGI	MGI:MGI:95728	Mouse	PMID:28778798
Biological Process	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning	Ift122	IMP		Mouse	MGI:MGI:4888042|PMID:21209331
Biological Process	GO:0001843	neural tube closure	Ift122	IMP		Mouse	MGI:MGI:3827087|PMID:19000668
Biological Process	GO:1905515	non-motile cilium assembly	Ift122	IMP		Mouse	PMID:21703454
Biological Process	GO:0036372	opsin transport	ift122	IMP	ZFIN:ZDB-GENO-170131-18	Zfish	PMID:27681595
Biological Process	GO:0045494	photoreceptor cell maintenance	ift122	IMP	ZFIN:ZDB-GENO-170131-18	Zfish	PMID:27681595
Biological Process	GO:0008594	photoreceptor cell morphogenesis	ift122	IMP	ZFIN:ZDB-GENO-170131-18	Zfish	PMID:27681595
Biological Process	GO:0061512	protein localization to cilium	IFT122	IMP		Human	PMID:20889716
Biological Process	GO:0061512	protein localization to cilium	IFT122	IMP		Human	PMID:29220510
Biological Process	GO:0061512	protein localization to cilium	Ift122	IMP		Mouse	MGI:MGI:4888042|PMID:21209331
Biological Process	GO:0008589	regulation of smoothened signaling pathway	ift122	IMP		Zfish	PMID:20493458|ZFIN:ZDB-PUB-100525-17
Biological Process	GO:0007227	signal transduction downstream of smoothened	Ift122	IMP		Mouse	MGI:MGI:4888042|PMID:21209331
Biological Process	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	Ift122	IGI	MGI:MGI:2443231	Mouse	PMID:22689656

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern