Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Igf1r

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes IGF1R
- Mouse genes Igf1r
- Rat genes Igf1r
- Zfish genes igf1ra,igf1rb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Igf1r

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	igf1ra	IGI	ZFIN:ZDB-MRPHLNO-061130-3,ZFIN:ZDB-MRPHLNO-061130-4,ZFIN:ZDB-MRPHLNO-061130-5,ZFIN:ZDB-MRPHLNO-061130-6	Zfish	PMID:17332774
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	igf1rb	IGI	ZFIN:ZDB-MRPHLNO-061130-3,ZFIN:ZDB-MRPHLNO-061130-4,ZFIN:ZDB-MRPHLNO-061130-5,ZFIN:ZDB-MRPHLNO-061130-6	Zfish	PMID:17332774
Molecular Function	GO:0001965	G-protein alpha-subunit binding	Igf1r	IPI	RGD:2716	Rat	PMID:19764351\|RGD:5509824
Molecular Function	GO:0042802	identical protein binding	IGF1R	IPI	UniProtKB:P08069	Human	PMID:11448933
Molecular Function	GO:0042802	identical protein binding	IGF1R	IPI	UniProtKB:P08069	Human	PMID:17586502
Molecular Function	GO:0042802	identical protein binding	IGF1R	IPI	UniProtKB:P08069	Human	PMID:21645859
Molecular Function	GO:0043559	insulin binding	IGF1R	IPI	UniProtKB:P01308	Human	PMID:8452530
Molecular Function	GO:0005158	insulin receptor binding	IGF1R	IDA		Human	PMID:8452530
Molecular Function	GO:0043560	insulin receptor substrate binding	IGF1R	IPI	UniProtKB:P35568	Human	PMID:7541045
Molecular Function	GO:0043560	insulin receptor substrate binding	Igf1r	IPI	RGD:2922	Rat	PMID:15272025\|RGD:1581313
Molecular Function	GO:0005520	insulin-like growth factor binding	IGF1R	IDA		Human	PMID:1846292
Molecular Function	GO:0005520	insulin-like growth factor binding	IGF1R	IDA		Human	PMID:7679099
Molecular Function	GO:0005520	insulin-like growth factor binding	Igf1r	IPI	PR:P05017	Mouse	PMID:14566968
Molecular Function	GO:0005520	insulin-like growth factor binding	igf1ra	IPI	UniProtKB:Q90VV9	Zfish	PMID:11956169
Molecular Function	GO:0005520	insulin-like growth factor binding	igf1rb	IPI	UniProtKB:Q90VV9	Zfish	PMID:11956169
Molecular Function	GO:0031994	insulin-like growth factor I binding	IGF1R	IDA		Human	PMID:19578119
Molecular Function	GO:0031994	insulin-like growth factor I binding	IGF1R	IPI	UniProtKB:P05019	Human	PMID:8452530
Molecular Function	GO:0005010	insulin-like growth factor receptor activity	IGF1R	IDA		Human	PMID:7679099
Molecular Function	GO:0005010	insulin-like growth factor receptor activity	Igf1r	IGI	MGI:MGI:96434	Mouse	PMID:33567274
Molecular Function	GO:0005010	insulin-like growth factor receptor activity	Igf1r	IGI		Mouse	PMID:33567274
Molecular Function	GO:0005010	insulin-like growth factor receptor activity	Igf1r	IDA		Mouse	PMID:32439763
Molecular Function	GO:0005010	insulin-like growth factor receptor activity	Igf1r	IDA		Rat	PMID:16909201\|RGD:12904886
Molecular Function	GO:0140677	molecular function activator activity	Igf1r	IGI	UniProtKB:P08069	Mouse	PMID:9024787
Molecular Function	GO:0140677	molecular function activator activity	Igf1r	IDA		Mouse	PMID:7799946
Molecular Function	GO:0140677	molecular function activator activity	Igf1r	IMP	MGI:MGI:2386329	Mouse	PMID:12483226
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	IGF1R	IPI	UniProtKB:P27986	Human	PMID:7541045
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P41240	Human	PMID:10026153
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:Q9NZN5	Human	PMID:11724822
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P61981	Human	PMID:12482592
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:Q99683	Human	PMID:12556535
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P05556	Human	PMID:15289498
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P49407	Human	PMID:15878855
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P18031	Human	PMID:15976035
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P40763	Human	PMID:15998644
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P18031	Human	PMID:16926280
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P05019	Human	PMID:21645859
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:Q01995	Human	PMID:22245152
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P35222	Human	PMID:22261717
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:Q9UJU2	Human	PMID:22261717
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P27986	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:Q9Y2W7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P05019	Human	PMID:26027733
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:Q91X58	Human	PMID:26692333
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P29350	Human	PMID:28065597
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P35813	Human	PMID:28065597
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:Q06124	Human	PMID:28065597
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:Q9Y2W7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:O00459	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P05556	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P06213	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P18031	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P27986	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:Q06124	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:O00459	Human	PMID:7541045
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P29353	Human	PMID:7541045
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P29353-2	Human	PMID:7541045
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P27986	Human	PMID:7589433
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P27986	Human	PMID:7642582
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:Q06124	Human	PMID:7642582
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P01317	Human	PMID:8452530
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P05019	Human	PMID:8452530
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P27986	Human	PMID:8603569
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:Q06124	Human	PMID:8895367
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:P18031	Human	PMID:8999839
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:Q64010	Human	PMID:9480911
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:O14508	Human	PMID:9727029
Molecular Function	GO:0005515	protein binding	IGF1R	IPI	UniProtKB:O15524	Human	PMID:9727029
Molecular Function	GO:0005515	protein binding	Igf1r	IPI	PR:Q60760	Mouse	PMID:12771153
Molecular Function	GO:0005515	protein binding	Igf1r	IPI	PR:Q91VH2	Mouse	PMID:12917015
Molecular Function	GO:0005515	protein binding	Igf1r	IPI	PR:Q99MR1	Mouse	PMID:12771153
Molecular Function	GO:0005515	protein binding	Igf1r	IPI	RGD:1309017\|RGD:620225	Rat	PMID:11423532\|RGD:1579732
Molecular Function	GO:0005515	protein binding	Igf1r	IPI	RGD:2405	Rat	PMID:12837295\|RGD:11568682
Molecular Function	GO:0005515	protein binding	Igf1r	IPI	RGD:2917	Rat	PMID:22173225\|RGD:10045990
Molecular Function	GO:0140318	protein transporter activity	IGF1R	IMP		Human	PMID:16306401
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	Igf1r	IGI	MGI:MGI:96434	Mouse	PMID:33567274
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	Igf1r	IGI		Mouse	PMID:33567274
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	Igf1r	IDA		Mouse	PMID:32439763
Molecular Function	GO:0004713	protein tyrosine kinase activity	IGF1R	IDA		Human	PMID:11162456
Molecular Function	GO:0004713	protein tyrosine kinase activity	IGF1R	IMP		Human	PMID:11884589
Molecular Function	GO:0004713	protein tyrosine kinase activity	IGF1R	IDA		Human	PMID:7679099
Molecular Function	GO:0004713	protein tyrosine kinase activity	Igf1r	IGI	UniProtKB:P08069	Mouse	PMID:9024787
Molecular Function	GO:0004713	protein tyrosine kinase activity	Igf1r	IDA		Mouse	PMID:7799946
Molecular Function	GO:0004713	protein tyrosine kinase activity	Igf1r	IMP	MGI:MGI:2386329	Mouse	PMID:12483226
Molecular Function	GO:0004713	protein tyrosine kinase activity	Igf1r	IDA		Rat	PMID:16909201\|RGD:12904886
Molecular Function	GO:0044877	protein-containing complex binding	Igf1r	IDA		Rat	PMID:15272025\|RGD:1581313
Cellular Component	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex	IGF1R	IDA		Human	PMID:19578119
Cellular Component	GO:0030424	axon	Igf1r	IDA		Rat	PMID:23349896\|RGD:10046026
Cellular Component	GO:0005901	caveola	Igf1r	IDA		Rat	PMID:18022157\|RGD:2311510
Cellular Component	GO:0005737	cytoplasm	Igf1r	IDA		Rat	PMID:12800242\|RGD:10045984
Cellular Component	GO:0098978	glutamatergic synapse	Igf1r	IDA		Mouse	PMID:28683263
Cellular Component	GO:0098978	glutamatergic synapse	Igf1r	EXP		Mouse	PMID:28683263
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IGF1R	IDA		Human	PMID:8452530
Cellular Component	GO:0016020	membrane	IGF1R	IDA		Human	PMID:8452530
Cellular Component	GO:0016020	membrane	Igf1r	IDA		Mouse	PMID:7931420
Cellular Component	GO:0043005	neuron projection	Igf1r	IDA		Rat	PMID:16845384\|RGD:1624300
Cellular Component	GO:0043025	neuronal cell body	Igf1r	IDA		Rat	PMID:19862643\|RGD:10045872
Cellular Component	GO:0005634	nucleus	Igf1r	IDA		Rat	PMID:19862643\|RGD:10045872
Cellular Component	GO:0005886	plasma membrane	Igf1r	IDA		Mouse	PMID:18451178
Cellular Component	GO:0005886	plasma membrane	Igf1r	IDA		Mouse	PMID:23695157
Cellular Component	GO:0005886	plasma membrane	Igf1r	IDA		Rat	PMID:12800242\|RGD:10045984
Cellular Component	GO:1902911	protein kinase complex	IGF1R	IDA		Human	PMID:1846292
Cellular Component	GO:0043235	receptor complex	IGF1R	IDA		Human	PMID:23382219
Cellular Component	GO:0030315	T-tubule	Igf1r	IDA		Mouse	PMID:23695157
Cellular Component	GO:0030315	T-tubule	Igf1r	IDA		Rat	PMID:23118311\|RGD:10046017
Biological Process	GO:0030325	adrenal gland development	Igf1r	IGI	UniProtKB:P15208	Mouse	MGI:MGI:5493430\|PMID:23300479
Biological Process	GO:0007568	aging	Igf1r	IEP		Rat	PMID:12137935\|RGD:729367
Biological Process	GO:0097242	amyloid-beta clearance	IGF1R	IMP		Human	PMID:19406747
Biological Process	GO:0009887	animal organ morphogenesis	Igf1r	IMP	MGI:MGI:1926486	Mouse	PMID:12101187
Biological Process	GO:0009952	anterior/posterior pattern specification	igf1ra	IMP		Zfish	PMID:15602699
Biological Process	GO:0007409	axonogenesis	Igf1r	IMP		Rat	PMID:16845384\|RGD:1624300
Biological Process	GO:0007420	brain development	Igf1r	IMP	MGI:MGI:1926486	Mouse	PMID:12904469
Biological Process	GO:0043010	camera-type eye development	igf1ra	IMP	ZFIN:ZDB-MRPHLNO-061130-3,ZFIN:ZDB-MRPHLNO-061130-4	Zfish	PMID:16705083
Biological Process	GO:0043010	camera-type eye development	igf1rb	IMP	ZFIN:ZDB-MRPHLNO-061130-5,ZFIN:ZDB-MRPHLNO-061130-6	Zfish	PMID:16705083
Biological Process	GO:0003230	cardiac atrium development	Igf1r	IEP		Rat	PMID:15486038\|RGD:12904917
Biological Process	GO:1904045	cellular response to aldosterone	Igf1r	IEP		Rat	PMID:22173225\|RGD:10045990
Biological Process	GO:1904646	cellular response to amyloid-beta	IGF1R	IGI	UniProtKB:P05019	Human	PMID:22635104
Biological Process	GO:1904385	cellular response to angiotensin	Igf1r	IEP		Rat	PMID:8579617\|RGD:10046011
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Igf1r	IEP		Rat	PMID:19853640\|RGD:12904722
Biological Process	GO:0071392	cellular response to estradiol stimulus	Igf1r	IEP		Rat	PMID:10650946\|RGD:10045989
Biological Process	GO:0071333	cellular response to glucose stimulus	Igf1r	IMP	MGI:MGI:2386329	Mouse	PMID:21677284
Biological Process	GO:0071333	cellular response to glucose stimulus	Igf1r	IEP		Rat	PMID:20633551\|RGD:10045986
Biological Process	GO:0032869	cellular response to insulin stimulus	Igf1r	IMP	MGI:MGI:2386329	Mouse	PMID:21677284
Biological Process	GO:0032869	cellular response to insulin stimulus	Igf1r	IEP		Rat	PMID:20013160\|RGD:10046039
Biological Process	GO:1990314	cellular response to insulin-like growth factor stimulus	Igf1r	IPI	RGD:2405	Rat	PMID:12837295\|RGD:11568682
Biological Process	GO:1990314	cellular response to insulin-like growth factor stimulus	Igf1r	IEP		Rat	PMID:23349896\|RGD:10046026
Biological Process	GO:0071260	cellular response to mechanical stimulus	Igf1r	IEP		Rat	PMID:21854769\|RGD:10046007
Biological Process	GO:0071393	cellular response to progesterone stimulus	Igf1r	IEP		Rat	PMID:19853640\|RGD:12904722
Biological Process	GO:0071394	cellular response to testosterone stimulus	Igf1r	IEP		Rat	PMID:10650946\|RGD:10045989
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Igf1r	IPI	RGD:2405	Rat	PMID:12837295\|RGD:11568682
Biological Process	GO:0034224	cellular response to zinc ion starvation	Igf1r	IEP		Rat	PMID:21893222\|RGD:151667428
Biological Process	GO:0090398	cellular senescence	Igf1r	IEP		Rat	PMID:19862643\|RGD:10045872
Biological Process	GO:0021549	cerebellum development	Igf1r	IMP		Rat	PMID:21443795\|RGD:12904969
Biological Process	GO:0021549	cerebellum development	Igf1r	IEP		Rat	PMID:23397157\|RGD:10403039
Biological Process	GO:0043009	chordate embryonic development	igf1ra	IGI	ZFIN:ZDB-GENE-020503-2	Zfish	PMID:16705083
Biological Process	GO:0043009	chordate embryonic development	igf1ra	IMP	ZFIN:ZDB-MRPHLNO-061130-4	Zfish	PMID:16705083
Biological Process	GO:0043009	chordate embryonic development	igf1ra	IMP	ZFIN:ZDB-MRPHLNO-061130-3	Zfish	PMID:16705083
Biological Process	GO:0043009	chordate embryonic development	igf1ra	IMP	ZFIN:ZDB-MRPHLNO-061130-3,ZFIN:ZDB-MRPHLNO-061130-4	Zfish	PMID:16705083
Biological Process	GO:0043009	chordate embryonic development	igf1rb	IMP	ZFIN:ZDB-MRPHLNO-061130-5,ZFIN:ZDB-MRPHLNO-061130-6	Zfish	PMID:16705083
Biological Process	GO:0043009	chordate embryonic development	igf1rb	IMP	ZFIN:ZDB-MRPHLNO-061130-5	Zfish	PMID:16705083
Biological Process	GO:0043009	chordate embryonic development	igf1rb	IMP	ZFIN:ZDB-MRPHLNO-061130-6	Zfish	PMID:16705083
Biological Process	GO:0043009	chordate embryonic development	igf1rb	IGI	ZFIN:ZDB-GENE-020503-1	Zfish	PMID:16705083
Biological Process	GO:0097062	dendritic spine maintenance	Igf1r	IGI	UniProtKB:P15127	Rat	PMID:19406747\|RGD:13210538
Biological Process	GO:0031076	embryonic camera-type eye development	igf1ra	IGI	ZFIN:ZDB-MRPHLNO-061130-3,ZFIN:ZDB-MRPHLNO-061130-4,ZFIN:ZDB-MRPHLNO-061130-5,ZFIN:ZDB-MRPHLNO-061130-6	Zfish	PMID:17332774
Biological Process	GO:0031076	embryonic camera-type eye development	igf1rb	IGI	ZFIN:ZDB-MRPHLNO-061130-3,ZFIN:ZDB-MRPHLNO-061130-4,ZFIN:ZDB-MRPHLNO-061130-5,ZFIN:ZDB-MRPHLNO-061130-6	Zfish	PMID:17332774
Biological Process	GO:0008544	epidermis development	Igf1r	IMP		Mouse	PMID:23906066
Biological Process	GO:0030010	establishment of cell polarity	Igf1r	IMP		Rat	PMID:16845384\|RGD:1624300
Biological Process	GO:0044849	estrous cycle	Igf1r	IMP		Rat	PMID:17567960\|RGD:10046043
Biological Process	GO:0031017	exocrine pancreas development	Igf1r	IMP	MGI:MGI:1926486	Mouse	PMID:12101187
Biological Process	GO:0031101	fin regeneration	igf1ra	IMP	ZFIN:ZDB-MRPHLNO-061130-3	Zfish	PMID:20179093
Biological Process	GO:0031101	fin regeneration	igf1rb	IMP	ZFIN:ZDB-MRPHLNO-061130-5	Zfish	PMID:20179093
Biological Process	GO:0008354	germ cell migration	igf1rb	IMP		Zfish	PMID:18566124
Biological Process	GO:0008354	germ cell migration	igf1rb	IMP	ZFIN:ZDB-MRPHLNO-061130-5,ZFIN:ZDB-MRPHLNO-061130-6	Zfish	PMID:17362906
Biological Process	GO:0007507	heart development	igf1ra	IMP	ZFIN:ZDB-MRPHLNO-061130-3,ZFIN:ZDB-MRPHLNO-061130-4	Zfish	PMID:16705083
Biological Process	GO:0007507	heart development	igf1rb	IMP	ZFIN:ZDB-MRPHLNO-061130-5,ZFIN:ZDB-MRPHLNO-061130-6	Zfish	PMID:16705083
Biological Process	GO:0003007	heart morphogenesis	igf1ra	IGI	ZFIN:ZDB-MRPHLNO-061130-3,ZFIN:ZDB-MRPHLNO-061130-4,ZFIN:ZDB-MRPHLNO-061130-5,ZFIN:ZDB-MRPHLNO-061130-6	Zfish	PMID:17332774
Biological Process	GO:0003007	heart morphogenesis	igf1rb	IGI	ZFIN:ZDB-MRPHLNO-061130-3,ZFIN:ZDB-MRPHLNO-061130-4,ZFIN:ZDB-MRPHLNO-061130-5,ZFIN:ZDB-MRPHLNO-061130-6	Zfish	PMID:17332774
Biological Process	GO:0021766	hippocampus development	Igf1r	IEP		Rat	PMID:22042446\|RGD:10403040
Biological Process	GO:0006955	immune response	IGF1R	IMP		Human	PMID:16886151
Biological Process	GO:0008286	insulin receptor signaling pathway	Igf1r	IMP		Rat	PMID:19406747\|RGD:13210538
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGF1R	IDA		Human	PMID:7679099
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Igf1r	IGI	UniProtKB:P08069	Mouse	PMID:9024787
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Igf1r	IGI	MGI:MGI:96432	Mouse	PMID:32697974
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Igf1r	IGI	MGI:MGI:96432	Mouse	PMID:8402901
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Igf1r	IGI	MGI:MGI:96434	Mouse	PMID:9281335
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Igf1r	IMP	MGI:MGI:2386329	Mouse	PMID:12483226
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Igf1r	IGI	UniProtKB:P05019	Mouse	PMID:32439763
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Igf1r	IDA		Mouse	PMID:29348399
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	igf1ra	IDA		Zfish	PMID:11956169
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	igf1rb	IDA		Zfish	PMID:11956169
Biological Process	GO:0030238	male sex determination	Igf1r	IMP	MGI:MGI:1926486	Mouse	PMID:14628051
Biological Process	GO:0030879	mammary gland development	Igf1r	IMP	MGI:MGI:1926486	Mouse	PMID:17662267
Biological Process	GO:0000165	MAPK cascade	Igf1r	IMP	MGI:MGI:2386328	Mouse	PMID:18451178
Biological Process	GO:0140014	mitotic nuclear division	Igf1r	IMP		Mouse	PMID:23906066
Biological Process	GO:0043066	negative regulation of apoptotic process	IGF1R	IDA		Human	PMID:12556535
Biological Process	GO:1904193	negative regulation of cholangiocyte apoptotic process	Igf1r	IMP		Rat	PMID:17531559\|RGD:10046009
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Igf1r	IMP		Mouse	PMID:23906066
Biological Process	GO:1903944	negative regulation of hepatocyte apoptotic process	Igf1r	IMP		Rat	PMID:17531559\|RGD:10046009
Biological Process	GO:0043409	negative regulation of MAPK cascade	IGF1R	IDA		Human	PMID:12556535
Biological Process	GO:0043409	negative regulation of MAPK cascade	Igf1r	IMP	MGI:MGI:2386328	Mouse	PMID:18451178
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	Igf1r	IMP		Rat	PMID:19507001\|RGD:2311507
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Igf1r	IMP	MGI:MGI:2386328	Mouse	PMID:18451178
Biological Process	GO:0031175	neuron projection development	Igf1r	IDA		Rat	PMID:15567343\|RGD:1358316
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	IGF1R	IMP		Human	PMID:19545541
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	Igf1r	IDA		Mouse	PMID:10100151
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	IGF1R	IDA		Human	PMID:7692086
Biological Process	GO:0048680	positive regulation of axon regeneration	Igf1r	IMP		Rat	PMID:23349896\|RGD:10046026
Biological Process	GO:0030335	positive regulation of cell migration	IGF1R	IMP		Human	PMID:12138094
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGF1R	IMP		Human	PMID:12138094
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Igf1r	IMP		Mouse	MGI:MGI:5789853\|PMID:26910308
Biological Process	GO:0032467	positive regulation of cytokinesis	Igf1r	IMP		Rat	PMID:19507001\|RGD:2311507
Biological Process	GO:0048639	positive regulation of developmental growth	Igf1r	IMP		Mouse	MGI:MGI:5493430\|PMID:23300479
Biological Process	GO:0051054	positive regulation of DNA metabolic process	Igf1r	IMP		Rat	PMID:19507001\|RGD:2311507
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Igf1r	IGI	UniProtKB:P15208	Mouse	MGI:MGI:5493430\|PMID:23300479
Biological Process	GO:0043410	positive regulation of MAPK cascade	Igf1r	IMP	MGI:MGI:2386328	Mouse	PMID:18451178
Biological Process	GO:0051446	positive regulation of meiotic cell cycle	Igf1r	IGI	UniProtKB:P15208	Mouse	MGI:MGI:5493430\|PMID:23300479
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	Igf1r	IMP		Mouse	PMID:23906066
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	Igf1r	IMP		Rat	PMID:15110779\|RGD:10045881
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Igf1r	IMP		Rat	PMID:25186839\|RGD:10046020
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Igf1r	IMP	MGI:MGI:2386328	Mouse	PMID:18451178
Biological Process	GO:0043243	positive regulation of protein-containing complex disassembly	Igf1r	IGI	UniProtKB:P15127	Rat	PMID:19406747\|RGD:13210538
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Igf1r	IMP		Rat	PMID:21854769\|RGD:10046007
Biological Process	GO:0090031	positive regulation of steroid hormone biosynthetic process	Igf1r	IMP		Rat	PMID:17023532\|RGD:1600072
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Igf1r	IDA		Mouse	PMID:28683263
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Igf1r	EXP		Mouse	PMID:28683263
Biological Process	GO:0060740	prostate gland epithelium morphogenesis	Igf1r	IMP	MGI:MGI:2386328	Mouse	PMID:18451178
Biological Process	GO:0046777	protein autophosphorylation	IGF1R	IDA		Human	PMID:11162456
Biological Process	GO:0046777	protein autophosphorylation	IGF1R	IDA		Human	PMID:1846292
Biological Process	GO:0046777	protein autophosphorylation	IGF1R	IDA		Human	PMID:7679099
Biological Process	GO:0043491	protein kinase B signaling	Igf1r	IMP	MGI:MGI:2386328	Mouse	PMID:18451178
Biological Process	GO:0006468	protein phosphorylation	Igf1r	IDA		Mouse	PMID:18216249
Biological Process	GO:0046328	regulation of JNK cascade	IGF1R	IDA		Human	PMID:12556535
Biological Process	GO:0043279	response to alkaloid	Igf1r	IEP		Rat	PMID:30240970\|RGD:156430315
Biological Process	GO:0045471	response to ethanol	Igf1r	IDA		Rat	PMID:17645580\|RGD:12904760
Biological Process	GO:0045471	response to ethanol	Igf1r	IEP		Rat	PMID:24239160\|RGD:12904720
Biological Process	GO:0009725	response to hormone	Igf1r	IEP		Rat	PMID:30240970\|RGD:156430315
Biological Process	GO:0032868	response to insulin	Igf1r	IEP		Rat	PMID:19008912\|RGD:10046022
Biological Process	GO:1902065	response to L-glutamate	Igf1r	IDA		Rat	PMID:18981172\|RGD:2311508
Biological Process	GO:0035094	response to nicotine	Igf1r	IEP		Rat	PMID:22265867\|RGD:12904916
Biological Process	GO:0035094	response to nicotine	Igf1r	IEP		Rat	PMID:23454400\|RGD:10045858
Biological Process	GO:0031667	response to nutrient levels	Igf1r	IEP		Rat	PMID:21266509\|RGD:12904890
Biological Process	GO:0033197	response to vitamin E	Igf1r	IEP		Rat	PMID:17447016\|RGD:2311524
Biological Process	GO:0048752	semicircular canal morphogenesis	igf1ra	IMP	ZFIN:ZDB-MRPHLNO-061130-3,ZFIN:ZDB-MRPHLNO-061130-4	Zfish	PMID:16705083
Biological Process	GO:0048752	semicircular canal morphogenesis	igf1rb	IMP	ZFIN:ZDB-MRPHLNO-061130-5,ZFIN:ZDB-MRPHLNO-061130-6	Zfish	PMID:16705083
Biological Process	GO:0021522	spinal cord motor neuron differentiation	igf1ra	IMP	ZFIN:ZDB-MRPHLNO-061130-3,ZFIN:ZDB-MRPHLNO-061130-4	Zfish	PMID:16705083
Biological Process	GO:0021522	spinal cord motor neuron differentiation	igf1rb	IMP	ZFIN:ZDB-MRPHLNO-061130-5,ZFIN:ZDB-MRPHLNO-061130-6	Zfish	PMID:16705083
Biological Process	GO:0045056	transcytosis	IGF1R	IMP		Human	PMID:16306401

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.