Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IGF2R
  • Mouse genes Igf2r
  • Rat genes Igf2r
  • Zfish genes igf2r
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Igf2r

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	Igf2r	IDA		Rat	PMID:11247783|RGD:1581738
Molecular Function	GO:0001965	G-protein alpha-subunit binding	Igf2r	IDA		Rat	PMID:16407557|RGD:1624326
Molecular Function	GO:0042802	identical protein binding	IGF2R	IPI	UniProtKB:P11717	Human	PMID:22681933
Molecular Function	GO:0005520	insulin-like growth factor binding	Igf2r	IPI	PR:P09535	Mouse	PMID:14566968
Molecular Function	GO:0031995	insulin-like growth factor II binding	Igf2r	IDA		Rat	PMID:16407557|RGD:1624326
Molecular Function	GO:0005537	mannose binding	Igf2r	IDA		Mouse	PMID:2963825
Molecular Function	GO:0051219	phosphoprotein binding	IGF2R	IDA		Human	PMID:10900005
Molecular Function	GO:0005515	protein binding	IGF2R	IDA		Human	PMID:10900005
Molecular Function	GO:0005515	protein binding	IGF2R	IPI	UniProtKB:P27487	Human	PMID:10900005
Molecular Function	GO:0005515	protein binding	IGF2R	IPI	UniProtKB:Q9NZ52	Human	PMID:11387475
Molecular Function	GO:0005515	protein binding	IGF2R	IPI	UniProtKB:Q9UJY5	Human	PMID:11387475
Molecular Function	GO:0005515	protein binding	IGF2R	IPI	UniProtKB:Q9UJY5	Human	PMID:11390366
Molecular Function	GO:0005515	protein binding	IGF2R	IPI	UniProtKB:Q6VY07	Human	PMID:16977309
Molecular Function	GO:0005515	protein binding	IGF2R	IPI	UniProtKB:Q9NZ52	Human	PMID:16977309
Molecular Function	GO:0005515	protein binding	IGF2R	IPI	UniProtKB:P01344-1	Human	PMID:17850746
Molecular Function	GO:0005515	protein binding	IGF2R	IPI	UniProtKB:P01344	Human	PMID:18046459
Molecular Function	GO:0005515	protein binding	IGF2R	IPI	UniProtKB:Q9UJY5	Human	PMID:20676133
Molecular Function	GO:0005515	protein binding	Igf2r	IPI	PR:P04095	Mouse	PMID:2963825
Molecular Function	GO:0001972	retinoic acid binding	Igf2r	IDA		Rat	PMID:10470859|RGD:2311628
Molecular Function	GO:1905394	retromer complex binding	IGF2R	IDA		Human	PMID:18817523
Cellular Component	GO:0009986	cell surface	IGF2R	IDA		Human	PMID:10900005
Cellular Component	GO:0030118	clathrin coat	Igf2r	IDA		Rat	PMID:2971973|RGD:2303173
Cellular Component	GO:0005769	early endosome	IGF2R	IMP		Human	PMID:17959629
Cellular Component	GO:0030139	endocytic vesicle	IGF2R	IDA		Human	PMID:10900005
Cellular Component	GO:0005768	endosome	IGF2R	IDA		Human	PMID:15078902
Cellular Component	GO:0005768	endosome	Igf2r	IDA		Rat	PMID:15033478|RGD:2311624
Cellular Component	GO:0010008	endosome membrane	IGF2R	IDA		Human	PMID:18817523
Cellular Component	GO:0070062	extracellular exosome	IGF2R	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	IGF2R	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	Igf2r	IDA		Rat	PMID:10470859|RGD:2311628
Cellular Component	GO:0005925	focal adhesion	IGF2R	HDA		Human	PMID:21423176
Cellular Component	GO:0005794	Golgi apparatus	IGF2R	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	IGF2R	IDA		Human	PMID:18817523
Cellular Component	GO:0005770	late endosome	IGF2R	IDA		Human	PMID:22456507
Cellular Component	GO:0005770	late endosome	Igf2r	IDA		Rat	PMID:19337031|RGD:4892338
Cellular Component	GO:0016020	membrane	IGF2R	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Igf2r	IDA		Mouse	PMID:2963825
Cellular Component	GO:0005641	nuclear envelope lumen	Igf2r	IDA		Mouse	PMID:12729502
Cellular Component	GO:0005634	nucleus	Igf2r	IDA		Mouse	PMID:12729502
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Igf2r	IDA		Rat	PMID:15033478|RGD:2311624
Cellular Component	GO:0005886	plasma membrane	Igf2r	IDA		Rat	PMID:16407557|RGD:1624326
Cellular Component	GO:0005802	trans-Golgi network	IGF2R	IMP		Human	PMID:17959629
Cellular Component	GO:0005802	trans-Golgi network	Igf2r	IDA		Rat	PMID:15033478|RGD:2311624
Cellular Component	GO:0030140	trans-Golgi network transport vesicle	IGF2R	IDA		Human	PMID:15078902
Biological Process	GO:0031100	animal organ regeneration	Igf2r	IEP		Rat	PMID:12547403|RGD:1298966
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Igf2r	IMP		Rat	PMID:19095737|RGD:2311517
Biological Process	GO:0001889	liver development	Igf2r	IDA		Rat	PMID:12127995|RGD:2311626
Biological Process	GO:0044794	positive regulation by host of viral process	IGF2R	IMP		Human	PMID:20889566
Biological Process	GO:0043065	positive regulation of apoptotic process	Igf2r	IMP		Rat	PMID:19095737|RGD:2311517
Biological Process	GO:0009791	post-embryonic development	Igf2r	IEP		Rat	PMID:18824840|RGD:2311621
Biological Process	GO:0042981	regulation of apoptotic process	Igf2r	IMP		Rat	PMID:16825605|RGD:1624325
Biological Process	GO:0032526	response to retinoic acid	Igf2r	IDA		Rat	PMID:9811861|RGD:2311629
Biological Process	GO:1904772	response to tetrachloromethane	Igf2r	IEP		Rat	PMID:9632637|RGD:14985245
Biological Process	GO:0007283	spermatogenesis	Igf2r	IEP		Rat	PMID:10993842|RGD:2311627

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern