Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IGFBP1
  • Mouse genes Igfbp1
  • Rat genes Igfbp1
  • Zfish genes igfbp1a,igfbp1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Igfbp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005520	insulin-like growth factor binding	Igfbp1	IPI	PR:P05017	Mouse	PMID:7679139
Molecular Function	GO:0031994	insulin-like growth factor I binding	IGFBP1	IDA		Human	PMID:21550830
Molecular Function	GO:0031994	insulin-like growth factor I binding	igfbp1a	IDA		Zfish	PMID:18769480
Molecular Function	GO:0031994	insulin-like growth factor I binding	igfbp1b	IDA		Zfish	PMID:18769480
Molecular Function	GO:0031995	insulin-like growth factor II binding	IGFBP1	IDA		Human	PMID:21550830
Molecular Function	GO:0031995	insulin-like growth factor II binding	igfbp1a	IDA		Zfish	PMID:18769480
Molecular Function	GO:0031995	insulin-like growth factor II binding	igfbp1b	IDA		Zfish	PMID:18769480
Molecular Function	GO:0005515	protein binding	IGFBP1	IPI	UniProtKB:P05019	Human	PMID:16924115
Molecular Function	GO:0005515	protein binding	IGFBP1	IPI	UniProtKB:P05019	Human	PMID:22578544
Molecular Function	GO:0005515	protein binding	IGFBP1	IPI	UniProtKB:Q8IXL6	Human	PMID:26091039
Molecular Function	GO:0005515	protein binding	IGFBP1	IPI	UniProtKB:G5E9A7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP1	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP1	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP1	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Cellular Component	GO:0005737	cytoplasm	igfbp1a	IDA		Zfish	PMID:21558420
Cellular Component	GO:0005615	extracellular space	Igfbp1	IDA		Mouse	PMID:7679139
Cellular Component	GO:0005615	extracellular space	Igfbp1	IDA		Mouse	PMID:7510770
Cellular Component	GO:0005615	extracellular space	Igfbp1	IDA		Rat	PMID:16166214|RGD:1625239
Cellular Component	GO:0005794	Golgi apparatus	IGFBP1	IDA		Human	GO_REF:0000052
Biological Process	GO:0007568	aging	Igfbp1	IEP		Rat	PMID:9751511|RGD:10402778
Biological Process	GO:0008286	insulin receptor signaling pathway	Igfbp1	IEP		Rat	PMID:11784721|RGD:729306
Biological Process	GO:0010259	multicellular organism aging	Igfbp1	IEP		Rat	PMID:9492067|RGD:152176652
Biological Process	GO:0008285	negative regulation of cell population proliferation	igfbp1a	IDA		Zfish	PMID:15644436
Biological Process	GO:0030307	positive regulation of cell growth	Igfbp1	IEP		Rat	PMID:1705004|RGD:1578549
Biological Process	GO:0031099	regeneration	igfbp1a	IMP	ZFIN:ZDB-GENO-161208-13	Zfish	PMID:27516442
Biological Process	GO:0001666	response to hypoxia	igfbp1a	IMP		Zfish	PMID:15644436
Biological Process	GO:0014070	response to organic cyclic compound	Igfbp1	IEP		Rat	PMID:7536658|RGD:152176653
Biological Process	GO:0042246	tissue regeneration	Igfbp1	IEP		Rat	PMID:1705004|RGD:1578549

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern