Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Igfbp2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes IGFBP2
- Mouse genes Igfbp2
- Rat genes Igfbp2
- Zfish genes igfbp2a,igfbp2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Igfbp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005520	insulin-like growth factor binding	Igfbp2	IPI	PR:P05017	Mouse	PMID:7679139
Molecular Function	GO:0005520	insulin-like growth factor binding	igfbp2a	IDA		Zfish	ZFIN:ZDB-PUB-040611-2
Molecular Function	GO:0005520	insulin-like growth factor binding	igfbp2b	IDA		Zfish	PMID:19081843
Molecular Function	GO:0031994	insulin-like growth factor I binding	IGFBP2	IDA		Human	PMID:19081843
Molecular Function	GO:0031994	insulin-like growth factor I binding	Igfbp2	IDA		Rat	PMID:2538475\|RGD:729148
Molecular Function	GO:0031994	insulin-like growth factor I binding	Igfbp2	IMP		Rat	PMID:2538475\|RGD:729148
Molecular Function	GO:0031994	insulin-like growth factor I binding	igfbp2a	IDA		Zfish	PMID:10611375\|ZFIN:ZDB-PUB-000111-5
Molecular Function	GO:0031994	insulin-like growth factor I binding	igfbp2b	IDA		Zfish	PMID:19081843\|ZFIN:ZDB-PUB-081218-26
Molecular Function	GO:0031995	insulin-like growth factor II binding	Igfbp2	IDA		Rat	PMID:1709938\|RGD:69857
Molecular Function	GO:0031995	insulin-like growth factor II binding	Igfbp2	IDA		Rat	PMID:2538475\|RGD:729148
Molecular Function	GO:0031995	insulin-like growth factor II binding	Igfbp2	IPI	UniProtKB:P01346	Rat	PMID:2538475\|RGD:729148
Molecular Function	GO:0031995	insulin-like growth factor II binding	Igfbp2	IPI	UniProtKB:P01346	Rat	PMID:2974285\|RGD:8553840
Molecular Function	GO:0031995	insulin-like growth factor II binding	igfbp2a	IPI	UniProtKB:P01344	Zfish	PMID:10611375\|ZFIN:ZDB-PUB-000111-5
Molecular Function	GO:0005515	protein binding	IGFBP2	IPI	UniProtKB:Q9C086	Human	PMID:19095771
Cellular Component	GO:0016324	apical plasma membrane	Igfbp2	IDA		Rat	PMID:10842239\|RGD:1626513
Cellular Component	GO:0031410	cytoplasmic vesicle	Igfbp2	IDA		Rat	PMID:15705658\|RGD:1626501
Cellular Component	GO:0070062	extracellular exosome	IGFBP2	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	Igfbp2	IDA		Rat	PMID:2426267\|RGD:8554742
Cellular Component	GO:0005576	extracellular region	Igfbp2	IDA		Rat	PMID:2480123\|RGD:8553399
Cellular Component	GO:0005615	extracellular space	IGFBP2	IDA		Human	PMID:15694994
Cellular Component	GO:0005615	extracellular space	Igfbp2	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Igfbp2	IDA		Mouse	PMID:7679139
Cellular Component	GO:0005615	extracellular space	Igfbp2	IDA		Mouse	PMID:7510770
Cellular Component	GO:0005615	extracellular space	Igfbp2	IDA		Rat	PMID:2538475\|RGD:729148
Cellular Component	GO:0005615	extracellular space	Igfbp2	IDA		Rat	PMID:9396554\|RGD:1626482
Biological Process	GO:0001525	angiogenesis	igfbp2a	IMP	ZFIN:ZDB-MRPHLNO-050517-3	Zfish	PMID:15618288
Biological Process	GO:0032870	cellular response to hormone stimulus	Igfbp2	IEP		Rat	PMID:16720626\|RGD:1626490
Biological Process	GO:0007565	female pregnancy	Igfbp2	IEP		Rat	PMID:17123939\|RGD:1598449
Biological Process	GO:0007507	heart development	igfbp2a	IMP	ZFIN:ZDB-MRPHLNO-050517-3	Zfish	PMID:15618288
Biological Process	GO:0008285	negative regulation of cell population proliferation	igfbp2a	IMP		Zfish	PMID:10611375\|ZFIN:ZDB-PUB-000111-5
Biological Process	GO:0008285	negative regulation of cell population proliferation	igfbp2a	IDA		Zfish	ZFIN:ZDB-PUB-040611-2
Biological Process	GO:0048640	negative regulation of developmental growth	igfbp2a	IMP		Zfish	PMID:10611375\|ZFIN:ZDB-PUB-000111-5
Biological Process	GO:0048640	negative regulation of developmental growth	igfbp2a	IMP		Zfish	PMID:19081843\|ZFIN:ZDB-PUB-081218-26
Biological Process	GO:0048640	negative regulation of developmental growth	igfbp2b	IMP		Zfish	PMID:19081843\|ZFIN:ZDB-PUB-081218-26
Biological Process	GO:0008156	negative regulation of DNA replication	igfbp2a	IMP		Zfish	PMID:10611375\|ZFIN:ZDB-PUB-000111-5
Biological Process	GO:0040015	negative regulation of multicellular organism growth	igfbp2a	IMP		Zfish	ZFIN:ZDB-PUB-040611-2
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IGFBP2	IDA		Human	PMID:15694994
Biological Process	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	igfbp2a	IMP		Zfish	PMID:10611375\|ZFIN:ZDB-PUB-000111-5
Biological Process	GO:0032355	response to estradiol	Igfbp2	IEP		Rat	PMID:10842239\|RGD:1626513
Biological Process	GO:0043627	response to estrogen	Igfbp2	IEP		Rat	PMID:12801995\|RGD:1582500
Biological Process	GO:0051384	response to glucocorticoid	Igfbp2	IEP		Rat	PMID:15705658\|RGD:1626501
Biological Process	GO:0010226	response to lithium ion	Igfbp2	IEP		Rat	PMID:16738484\|RGD:1626489
Biological Process	GO:0009612	response to mechanical stimulus	Igfbp2	IEP		Rat	PMID:17308996\|RGD:1626485
Biological Process	GO:0007584	response to nutrient	Igfbp2	IEP		Rat	PMID:15576465\|RGD:1626503
Biological Process	GO:0014070	response to organic cyclic compound	Igfbp2	IEP		Rat	PMID:7536658\|RGD:152176653
Biological Process	GO:0032526	response to retinoic acid	Igfbp2	IEP		Rat	PMID:11880314\|RGD:1643103
Biological Process	GO:0048545	response to steroid hormone	Igfbp2	IEP		Rat	PMID:10842239\|RGD:1626513
Biological Process	GO:0009410	response to xenobiotic stimulus	Igfbp2	IEP		Rat	PMID:15613074\|RGD:1626502
Biological Process	GO:0007165	signal transduction	Igfbp2	IEP		Rat	PMID:11914028\|RGD:729220

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.