Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IGFBP4
  • Mouse genes Igfbp4
  • Rat genes Igfbp4
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Igfbp4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005520	insulin-like growth factor binding	Igfbp4	IPI	PR:P05017	Mouse	PMID:7679139
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:P05019	Human	PMID:15642270
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:P05019	Human	PMID:16924115
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:P01344-3	Human	PMID:31467278
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:G5E9A7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:O14656	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:O60333-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:P28799	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:P54252	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP4	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Igfbp4	IPI	UniProtKB:O75581|UniProtKB:Q61091	Mouse	MGI:MGI:3801389|PMID:18528331
Cellular Component	GO:0005615	extracellular space	Igfbp4	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Igfbp4	IDA		Mouse	PMID:7510770
Cellular Component	GO:0005615	extracellular space	Igfbp4	IDA		Mouse	PMID:7679139
Biological Process	GO:0006954	inflammatory response	Igfbp4	IEP		Rat	PMID:11145587|RGD:61527
Biological Process	GO:0000165	MAPK cascade	Igfbp4	IGI	MGI:MGI:96438	Mouse	PMID:16675541
Biological Process	GO:0000165	MAPK cascade	Igfbp4	IGI	MGI:MGI:96440	Mouse	PMID:16675541
Biological Process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	Igfbp4	IGI	MGI:MGI:96440	Mouse	PMID:16675541
Biological Process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	Igfbp4	IGI	MGI:MGI:96438	Mouse	PMID:16675541
Biological Process	GO:0043410	positive regulation of MAPK cascade	Igfbp4	IGI	MGI:MGI:96440	Mouse	PMID:16675541
Biological Process	GO:0043410	positive regulation of MAPK cascade	Igfbp4	IGI	MGI:MGI:96438	Mouse	PMID:16675541
Biological Process	GO:0001558	regulation of cell growth	Igfbp4	IGI	MGI:MGI:96440	Mouse	PMID:16675541
Biological Process	GO:0001558	regulation of cell growth	Igfbp4	IGI	MGI:MGI:96438	Mouse	PMID:16675541
Biological Process	GO:0010906	regulation of glucose metabolic process	Igfbp4	IGI	MGI:MGI:96440	Mouse	PMID:16675541
Biological Process	GO:0010906	regulation of glucose metabolic process	Igfbp4	IGI	MGI:MGI:96438	Mouse	PMID:16675541
Biological Process	GO:0040008	regulation of growth	Igfbp4	IGI	MGI:MGI:96440	Mouse	PMID:16675541
Biological Process	GO:0040008	regulation of growth	Igfbp4	IGI	MGI:MGI:96438	Mouse	PMID:16675541
Biological Process	GO:0014070	response to organic cyclic compound	Igfbp4	IEP		Rat	PMID:7536658|RGD:152176653
Biological Process	GO:0044342	type B pancreatic cell proliferation	Igfbp4	IGI	MGI:MGI:96440	Mouse	PMID:16675541
Biological Process	GO:0044342	type B pancreatic cell proliferation	Igfbp4	IGI	MGI:MGI:96438	Mouse	PMID:16675541

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern