Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IGFBP5
  • Mouse genes Igfbp5
  • Rat genes Igfbp5
  • Zfish genes igfbp5a,igfbp5b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Igfbp5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001968	fibronectin binding	Igfbp5	IDA		Mouse	PMID:19236847
Molecular Function	GO:0005520	insulin-like growth factor binding	Igfbp5	IPI	PR:P09535	Mouse	PMID:14566968
Molecular Function	GO:0005520	insulin-like growth factor binding	Igfbp5	IPI	PR:P05017	Mouse	PMID:14566968
Molecular Function	GO:0005520	insulin-like growth factor binding	Igfbp5	IDA		Rat	PMID:1709938|RGD:69857
Molecular Function	GO:0031994	insulin-like growth factor I binding	IGFBP5	IPI	UniProtKB:P05019	Human	PMID:10766744
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:P07996	Human	PMID:15700281
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:O43889-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:O43889-2	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:O15393-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:O15529	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:O43315	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:O60883	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:O75712	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:O95279	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:O95377	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:O95471	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:O95484	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:O95859	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:P07306	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:P19397	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:P25024	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:P36382	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:P41181	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:P48165	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:P56747	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:P56880	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:P57739	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q13113	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q3KNW5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q4KMG9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q5T700	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q5TGU0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q68DC2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q6IBW4-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q6N075	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q6UX15-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q6ZS10	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q7Z5P4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q7Z7N9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q86VI4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q86WI0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q86WK6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q8IVF2-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q8IYS2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q8N205-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q8NBJ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q8NFJ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q8TB40	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q8TBE3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q8TDV0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q8TED1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q8WY91	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q8WZ55	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q96A25	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q96BI3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q96GZ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q96HJ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q96JW4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q96MV1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q96P31-6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q96Q45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q9BVX2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q9GZW8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q9GZY8-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q9H2H9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q9H9P2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q9HA82	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q9NPE6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q9NWC5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q9NYP7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q9NZD1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q9UBD6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q9UKG4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q9Y282	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q9Y320	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IGFBP5	IPI	UniProtKB:Q9Y676	Human	PMID:32296183
Cellular Component	GO:0042567	insulin-like growth factor ternary complex	IGFBP5	IDA		Human	PMID:9497324
Biological Process	GO:0007568	aging	Igfbp5	IEP		Rat	PMID:12397024|RGD:729113
Biological Process	GO:0071320	cellular response to cAMP	IGFBP5	IDA		Human	PMID:7559606
Biological Process	GO:0071407	cellular response to organic cyclic compound	IGFBP5	IDA		Human	PMID:7559606
Biological Process	GO:0007565	female pregnancy	Igfbp5	IMP		Mouse	MGI:MGI:3039207|PMID:15010534
Biological Process	GO:0042593	glucose homeostasis	Igfbp5	IMP	MGI:MGI:3663363	Mouse	PMID:19897600
Biological Process	GO:0042593	glucose homeostasis	Igfbp5	IGI	MGI:MGI:96439	Mouse	PMID:16675541
Biological Process	GO:0042593	glucose homeostasis	Igfbp5	IGI	MGI:MGI:96438	Mouse	PMID:16675541
Biological Process	GO:0031069	hair follicle morphogenesis	Igfbp5	IMP		Mouse	PMID:16024235
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Igfbp5	IMP		Mouse	PMID:16024235
Biological Process	GO:0035556	intracellular signal transduction	Igfbp5	IEP		Rat	PMID:12193414|RGD:729317
Biological Process	GO:0048286	lung alveolus development	Igfbp5	IMP		Mouse	MGI:MGI:3039207|PMID:15010534
Biological Process	GO:0060056	mammary gland involution	Igfbp5	IMP	MGI:MGI:3663363	Mouse	PMID:17255210
Biological Process	GO:0030336	negative regulation of cell migration	IGFBP5	IDA		Human	PMID:15700281
Biological Process	GO:0045926	negative regulation of growth	Igfbp5	IMP		Mouse	MGI:MGI:3039207|PMID:15010534
Biological Process	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	IGFBP5	IDA		Human	PMID:10766744
Biological Process	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	Igfbp5	IMP		Mouse	PMID:16024235
Biological Process	GO:1901862	negative regulation of muscle tissue development	Igfbp5	IMP		Mouse	MGI:MGI:3039207|PMID:15010534
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Igfbp5	IGI	MGI:MGI:87986	Mouse	PMID:19208758
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Igfbp5	IGI	MGI:MGI:88177	Mouse	PMID:19208758
Biological Process	GO:1904205	negative regulation of skeletal muscle hypertrophy	Igfbp5	IMP		Mouse	MGI:MGI:3039207|PMID:15010534
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	IGFBP5	IDA		Human	PMID:10766744
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	IGFBP5	IDA		Human	PMID:10766744
Biological Process	GO:0017148	negative regulation of translation	IGFBP5	IDA		Human	PMID:15700281
Biological Process	GO:0001649	osteoblast differentiation	Igfbp5	IEP		Mouse	MGI:MGI:3828402|PMID:16311053
Biological Process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	Igfbp5	IGI	MGI:MGI:96438	Mouse	PMID:16675541
Biological Process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	Igfbp5	IGI	MGI:MGI:96439	Mouse	PMID:16675541
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Igfbp5	IMP		Mouse	PMID:18762576
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	IGFBP5	IGI	RNAcentral:URS00001E3523_9606	Human	PMID:29016699
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	IGFBP5	IGI	RNAcentral:URS00001E3523_9606	Human	PMID:29016699
Biological Process	GO:0001558	regulation of cell growth	Igfbp5	IGI	MGI:MGI:96439	Mouse	PMID:16675541
Biological Process	GO:0001558	regulation of cell growth	Igfbp5	IGI	MGI:MGI:96438	Mouse	PMID:16675541
Biological Process	GO:0040008	regulation of growth	Igfbp5	IGI	MGI:MGI:96438	Mouse	PMID:16675541
Biological Process	GO:0040008	regulation of growth	Igfbp5	IGI	MGI:MGI:96439	Mouse	PMID:16675541
Biological Process	GO:0014070	response to organic cyclic compound	Igfbp5	IEP		Rat	PMID:7536658|RGD:152176653
Biological Process	GO:0051146	striated muscle cell differentiation	Igfbp5	IGI	MGI:MGI:87986	Mouse	PMID:18762576
Biological Process	GO:0051146	striated muscle cell differentiation	Igfbp5	IMP		Mouse	PMID:18762576
Biological Process	GO:0051146	striated muscle cell differentiation	Igfbp5	IGI	MGI:MGI:96434	Mouse	PMID:18762576
Biological Process	GO:0044342	type B pancreatic cell proliferation	Igfbp5	IGI	MGI:MGI:96439	Mouse	PMID:16675541
Biological Process	GO:0044342	type B pancreatic cell proliferation	Igfbp5	IGI	MGI:MGI:96438	Mouse	PMID:16675541

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern