Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IGHG1,IGHG2,IGHG3,IGHG4
  • Mouse genes Ighg2c
  • Rat genes Igh-6
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ighg2c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003823	antigen binding	Ighg2c	IDA		Mouse	PMID:9834074
Molecular Function	GO:0003823	antigen binding	Ighg2c	IDA		Mouse	PMID:12882831
Molecular Function	GO:0003823	antigen binding	Ighg2c	IDA		Mouse	PMID:11911824
Molecular Function	GO:0003823	antigen binding	Ighg2c	IDA		Mouse	PMID:11057672
Molecular Function	GO:0034988	Fc-gamma receptor I complex binding	IGHG1	IDA		Human	PMID:11711607
Molecular Function	GO:0005515	protein binding	IGHG1	IPI	UniProtKB:P31994	Human	PMID:11567028
Molecular Function	GO:0005515	protein binding	IGHG1	IPI	UniProtKB:P04488	Human	PMID:16646632
Molecular Function	GO:0005515	protein binding	IGHG1	IPI	UniProtKB:P12314	Human	PMID:25925696
Molecular Function	GO:0005515	protein binding	IGHG2	IPI	UniProtKB:Q28109	Human	PMID:16457820
Cellular Component	GO:0072562	blood microparticle	IGHG1	HDA		Human	PMID:22516433
Cellular Component	GO:0072562	blood microparticle	IGHG2	HDA		Human	PMID:22516433
Cellular Component	GO:0072562	blood microparticle	IGHG3	HDA		Human	PMID:22516433
Cellular Component	GO:0072562	blood microparticle	IGHG4	HDA		Human	PMID:22516433
Cellular Component	GO:0070062	extracellular exosome	IGHG1	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	IGHG2	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	IGHG3	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	IGHG4	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	IGHG1	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	IGHG1	HDA		Human	PMID:23580065
Cellular Component	GO:0005615	extracellular space	IGHG1	IDA		Human	PMID:25645918
Cellular Component	GO:0005615	extracellular space	IGHG2	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	IGHG2	HDA		Human	PMID:23580065
Cellular Component	GO:0005615	extracellular space	IGHG2	IDA		Human	PMID:25645918
Cellular Component	GO:0005615	extracellular space	IGHG3	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	IGHG3	HDA		Human	PMID:23580065
Cellular Component	GO:0005615	extracellular space	IGHG4	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	IGHG4	HDA		Human	PMID:23580065
Cellular Component	GO:0005615	extracellular space	Ighg2c	IDA		Mouse	PMID:17658279
Cellular Component	GO:0071735	IgG immunoglobulin complex	IGHG1	IPI		Human	PMID:11498595
Cellular Component	GO:0071735	IgG immunoglobulin complex	IGHG1	IPI		Human	PMID:22839360
Cellular Component	GO:0071735	IgG immunoglobulin complex	IGHG1	IPI		Human	PMID:9530559
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighg2c	IDA		Mouse	PMID:9834074
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighg2c	IDA		Mouse	PMID:16275384
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighg2c	IDA		Mouse	PMID:12882831
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighg2c	IDA		Mouse	PMID:11057672
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighg2c	IDA		Mouse	PMID:11911824
Biological Process	GO:0002250	adaptive immune response	IGHG1	IDA		Human	PMID:11498595
Biological Process	GO:0019731	antibacterial humoral response	Ighg2c	IDA		Mouse	PMID:9834074
Biological Process	GO:0019731	antibacterial humoral response	Ighg2c	IDA		Mouse	PMID:11911824
Biological Process	GO:0001788	antibody-dependent cellular cytotoxicity	IGHG1	IDA		Human	PMID:11711607
Biological Process	GO:0097278	complement-dependent cytotoxicity	IGHG1	IDA		Human	PMID:11711607
Biological Process	GO:0042742	defense response to bacterium	Ighg2c	IDA		Mouse	PMID:11911824
Biological Process	GO:0002455	humoral immune response mediated by circulating immunoglobulin	Ighg2c	IDA		Mouse	PMID:11057672
Biological Process	GO:0002455	humoral immune response mediated by circulating immunoglobulin	Ighg2c	IDA		Mouse	PMID:9834074
Biological Process	GO:0016064	immunoglobulin mediated immune response	Ighg2c	IDA		Mouse	PMID:12882831
Biological Process	GO:0001895	retina homeostasis	IGHG3	HEP		Human	PMID:23580065

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern