Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IGHM
  • Mouse genes Ighm
  • Rat genes
  • Zfish genes ighm
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ighm

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003823	antigen binding	Ighm	IDA		Mouse	PMID:12882831
Molecular Function	GO:0003823	antigen binding	Ighm	IDA		Mouse	PMID:8552190
Molecular Function	GO:0003823	antigen binding	Ighm	IDA		Mouse	PMID:14988498
Molecular Function	GO:0003823	antigen binding	Ighm	IDA		Mouse	PMID:8418208
Molecular Function	GO:0003823	antigen binding	Ighm	IDA		Mouse	PMID:7688139
Molecular Function	GO:0003823	antigen binding	Ighm	IDA		Mouse	PMID:8041705
Molecular Function	GO:0003823	antigen binding	Ighm	IDA		Mouse	PMID:10704460
Molecular Function	GO:0003823	antigen binding	Ighm	IDA		Mouse	PMID:8047141
Molecular Function	GO:0003823	antigen binding	Ighm	IDA		Mouse	PMID:8566034
Molecular Function	GO:0042802	identical protein binding	Ighm	IPI	UniProtKB:P01872	Mouse	MGI:MGI:5634874|PMID:24963139
Molecular Function	GO:0034987	immunoglobulin receptor binding	IGHM	IDA		Human	PMID:23250751
Molecular Function	GO:0034987	immunoglobulin receptor binding	Ighm	IPI	UniProtKB:Q2V8M5	Mouse	MGI:MGI:5640948|PMID:20031218
Molecular Function	GO:0042834	peptidoglycan binding	IGHM	IDA		Human	PMID:21786026
Molecular Function	GO:0031210	phosphatidylcholine binding	IGHM	IDA		Human	PMID:21786026
Molecular Function	GO:0005515	protein binding	Ighm	IPI	MGI:MGI:99546	Mouse	PMID:1373499
Molecular Function	GO:0003697	single-stranded DNA binding	IGHM	IDA		Human	PMID:21786026
Molecular Function	GO:0004888	transmembrane signaling receptor activity	Ighm	IDA		Mouse	PMID:1373499
Cellular Component	GO:0019815	B cell receptor complex	Ighm	IDA		Mouse	PMID:7477352
Cellular Component	GO:0019815	B cell receptor complex	Ighm	IDA		Mouse	PMID:8552190
Cellular Component	GO:0019815	B cell receptor complex	Ighm	IDA		Mouse	PMID:10704460
Cellular Component	GO:0019815	B cell receptor complex	Ighm	IDA		Mouse	PMID:9254656
Cellular Component	GO:0019815	B cell receptor complex	Ighm	IDA		Mouse	PMID:1373499
Cellular Component	GO:0019815	B cell receptor complex	Ighm	IDA		Mouse	PMID:14662849
Cellular Component	GO:0019815	B cell receptor complex	Ighm	IDA		Mouse	PMID:8626447
Cellular Component	GO:0019815	B cell receptor complex	Ighm	IDA		Mouse	PMID:8418208
Cellular Component	GO:0019815	B cell receptor complex	Ighm	IDA		Mouse	PMID:12882831
Cellular Component	GO:0019815	B cell receptor complex	Ighm	IDA		Mouse	PMID:14557413
Cellular Component	GO:0072562	blood microparticle	IGHM	HDA		Human	PMID:22516433
Cellular Component	GO:0009986	cell surface	IGHM	IDA		Human	PMID:22427638
Cellular Component	GO:0009986	cell surface	Ighm	IDA		Mouse	PMID:9707605
Cellular Component	GO:0009986	cell surface	Ighm	IDA		Mouse	PMID:25284781
Cellular Component	GO:0005737	cytoplasm	Ighm	IDA		Mouse	PMID:28923960
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:7477353
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:14557413
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:19861679
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:8666928
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:10979977
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:1373499
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:10704460
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:15909309
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:14662849
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:9254656
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:10072077
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:7477352
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:15843532
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:8566034
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:12882831
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:8041705
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:8626447
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:8418208
Cellular Component	GO:0009897	external side of plasma membrane	Ighm	IDA		Mouse	PMID:17941951
Cellular Component	GO:0070062	extracellular exosome	IGHM	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	IGHM	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	IGHM	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	IGHM	IDA		Human	PMID:25645918
Cellular Component	GO:0005615	extracellular space	Ighm	IDA		Mouse	MGI:MGI:5640948|PMID:20031218
Cellular Component	GO:0005615	extracellular space	Ighm	IDA		Mouse	PMID:17658279
Cellular Component	GO:0005615	extracellular space	Ighm	IDA		Mouse	PMID:9707605
Cellular Component	GO:0071757	hexameric IgM immunoglobulin complex	IGHM	IDA		Human	PMID:21786026
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighm	IDA		Mouse	PMID:8041705
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighm	IDA		Mouse	PMID:8418208
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighm	IDA		Mouse	PMID:12882831
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighm	IDA		Mouse	PMID:8552190
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighm	IDA		Mouse	PMID:14988498
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighm	IDA		Mouse	PMID:9492004
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighm	IDA		Mouse	PMID:10704460
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighm	IDA		Mouse	PMID:12867038
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighm	IDA		Mouse	PMID:7688139
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighm	IDA		Mouse	PMID:8047141
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighm	IDA		Mouse	PMID:11057672
Cellular Component	GO:0042571	immunoglobulin complex, circulating	Ighm	IDA		Mouse	PMID:8566034
Cellular Component	GO:0016020	membrane	Ighm	IDA		Mouse	PMID:9707605
Cellular Component	GO:0071756	pentameric IgM immunoglobulin complex	IGHM	IDA		Human	PMID:21786026
Cellular Component	GO:0071756	pentameric IgM immunoglobulin complex	IGHM	IDA		Human	PMID:23250751
Cellular Component	GO:0071756	pentameric IgM immunoglobulin complex	IGHM	IDA		Human	PMID:24145934
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Ighm	IDA		Mouse	PMID:1373499
Biological Process	GO:0002250	adaptive immune response	IGHM	IDA		Human	PMID:21786026
Biological Process	GO:0019731	antibacterial humoral response	IGHM	IDA		Human	PMID:21786026
Biological Process	GO:0019882	antigen processing and presentation	Ighm	IDA		Mouse	PMID:11854359
Biological Process	GO:0042113	B cell activation	Ighm	IDA		Mouse	PMID:8566034
Biological Process	GO:0002344	B cell affinity maturation	Ighm	IMP	MGI:MGI:2447178	Mouse	PMID:9707605
Biological Process	GO:0042100	B cell proliferation	Ighm	IDA		Mouse	PMID:10979977
Biological Process	GO:0042100	B cell proliferation	Ighm	IDA		Mouse	PMID:8666928
Biological Process	GO:0042100	B cell proliferation	Ighm	IDA		Mouse	PMID:9254656
Biological Process	GO:0042100	B cell proliferation	Ighm	IDA		Mouse	PMID:15240667
Biological Process	GO:0042100	B cell proliferation	Ighm	IDA		Mouse	PMID:14607964
Biological Process	GO:0050853	B cell receptor signaling pathway	Ighm	IDA		Mouse	PMID:9254656
Biological Process	GO:0050853	B cell receptor signaling pathway	Ighm	IDA		Mouse	PMID:7499277
Biological Process	GO:0050853	B cell receptor signaling pathway	Ighm	IDA		Mouse	PMID:1373499
Biological Process	GO:0050853	B cell receptor signaling pathway	Ighm	IDA		Mouse	PMID:8626447
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IGHM	IDA		Human	PMID:22427638
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Ighm	IMP	MGI:MGI:1857187	Mouse	PMID:14688352
Biological Process	GO:0045022	early endosome to late endosome transport	Ighm	IDA		Mouse	PMID:11854359
Biological Process	GO:0002455	humoral immune response mediated by circulating immunoglobulin	Ighm	IDA		Mouse	PMID:8041705
Biological Process	GO:0002455	humoral immune response mediated by circulating immunoglobulin	Ighm	IDA		Mouse	PMID:14988498
Biological Process	GO:0002455	humoral immune response mediated by circulating immunoglobulin	Ighm	IDA		Mouse	PMID:8566034
Biological Process	GO:0016064	immunoglobulin mediated immune response	Ighm	IDA		Mouse	PMID:8047141
Biological Process	GO:0016064	immunoglobulin mediated immune response	Ighm	IDA		Mouse	PMID:8552190
Biological Process	GO:0016064	immunoglobulin mediated immune response	Ighm	IDA		Mouse	PMID:8418208
Biological Process	GO:0016064	immunoglobulin mediated immune response	Ighm	IDA		Mouse	PMID:10704460
Biological Process	GO:0045087	innate immune response	IGHM	IDA		Human	PMID:21786026
Biological Process	GO:0000165	MAPK cascade	Ighm	IDA		Mouse	PMID:9254656
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Ighm	IDA		Mouse	PMID:7499277
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Ighm	IDA		Mouse	PMID:9254656
Biological Process	GO:0050871	positive regulation of B cell activation	Ighm	IDA		Mouse	PMID:8566034
Biological Process	GO:0050871	positive regulation of B cell activation	Ighm	IDA		Mouse	PMID:11854359
Biological Process	GO:0050871	positive regulation of B cell activation	Ighm	IDA		Mouse	PMID:10704460
Biological Process	GO:0030890	positive regulation of B cell proliferation	Ighm	IDA		Mouse	PMID:9254656
Biological Process	GO:0030890	positive regulation of B cell proliferation	Ighm	IDA		Mouse	PMID:8666928
Biological Process	GO:0030890	positive regulation of B cell proliferation	Ighm	IDA		Mouse	PMID:10704460
Biological Process	GO:0030890	positive regulation of B cell proliferation	Ighm	IDA		Mouse	PMID:15240667
Biological Process	GO:0030890	positive regulation of B cell proliferation	Ighm	IDA		Mouse	PMID:10979977
Biological Process	GO:0030890	positive regulation of B cell proliferation	Ighm	IDA		Mouse	PMID:8552190
Biological Process	GO:0030890	positive regulation of B cell proliferation	Ighm	IDA		Mouse	PMID:14607964
Biological Process	GO:0045807	positive regulation of endocytosis	Ighm	IDA		Mouse	PMID:11854359
Biological Process	GO:0050778	positive regulation of immune response	Ighm	IMP	MGI:MGI:2447178	Mouse	PMID:9707605
Biological Process	GO:0043410	positive regulation of MAPK cascade	Ighm	IDA		Mouse	PMID:9254656
Biological Process	GO:0043410	positive regulation of MAPK cascade	Ighm	IDA		Mouse	PMID:8626447
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Ighm	IDA		Mouse	PMID:1373499
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Ighm	IDA		Mouse	PMID:9254656
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Ighm	IDA		Mouse	PMID:7499277
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Ighm	IDA		Mouse	PMID:8626447
Biological Process	GO:0022604	regulation of cell morphogenesis	Ighm	IMP	MGI:MGI:2447178	Mouse	PMID:9707605
Biological Process	GO:0002637	regulation of immunoglobulin production	Ighm	IMP	MGI:MGI:2447178	Mouse	PMID:9707605
Biological Process	GO:0032496	response to lipopolysaccharide	ighm	IDA		Zfish	PMID:25725401

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern