Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IHH
  • Mouse genes Ihh
  • Rat genes Ihh
  • Zfish genes ihha,ihhb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ihh

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	IHH	IDA		Human	PMID:21537345
Molecular Function	GO:0005113	patched binding	IHH	IDA		Human	PMID:11472839
Molecular Function	GO:0005113	patched binding	IHH	IPI	UniProtKB:Q61115	Human	PMID:21537345
Molecular Function	GO:0005113	patched binding	Ihh	IPI	UniProtKB:Q13635|UniProtKB:Q9Y6C5	Mouse	MGI:MGI:1313055|PMID:9811851
Molecular Function	GO:0005515	protein binding	IHH	IPI	UniProtKB:Q9BWV1	Human	PMID:20519495
Molecular Function	GO:0005515	protein binding	Ihh	IPI	UniProtKB:Q9WU59	Mouse	PMID:10050855
Molecular Function	GO:0005515	protein binding	Ihh	IPI	PR:Q9JJS0	Mouse	PMID:25639508
Cellular Component	GO:0031012	extracellular matrix	Ihh	IDA		Mouse	PMID:11476578
Cellular Component	GO:0005886	plasma membrane	IHH	IDA		Human	PMID:21537345
Biological Process	GO:0045453	bone resorption	Ihh	IDA		Mouse	PMID:10208865
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:15689378
Biological Process	GO:0043010	camera-type eye development	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:18582859
Biological Process	GO:0060220	camera-type eye photoreceptor cell fate commitment	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:18582859
Biological Process	GO:0051216	cartilage development	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:17191253
Biological Process	GO:0001708	cell fate specification	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:18582859
Biological Process	GO:0048469	cell maturation	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:15576404
Biological Process	GO:0008283	cell population proliferation	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:16284117
Biological Process	GO:0002062	chondrocyte differentiation	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:16284117
Biological Process	GO:0002062	chondrocyte differentiation	Ihh	IDA		Mouse	PMID:15951842
Biological Process	GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis	Ihh	IMP		Mouse	PMID:25639508
Biological Process	GO:0035988	chondrocyte proliferation	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:16935278
Biological Process	GO:0009790	embryo development	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:17881493
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:18582859
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:10821773
Biological Process	GO:0042733	embryonic digit morphogenesis	Ihh	IGI	MGI:MGI:1347521	Mouse	PMID:20660756
Biological Process	GO:0042733	embryonic digit morphogenesis	Ihh	IMP	MGI:MGI:3842979	Mouse	PMID:20660756
Biological Process	GO:0009880	embryonic pattern specification	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:18582859
Biological Process	GO:0072498	embryonic skeletal joint development	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:17191253
Biological Process	GO:0060350	endochondral bone morphogenesis	Ihh	IMP		Mouse	MGI:MGI:1351296|PMID:10631175
Biological Process	GO:0060350	endochondral bone morphogenesis	Ihh	IMP		Mouse	MGI:MGI:1344187|PMID:10465785
Biological Process	GO:0048484	enteric nervous system development	ihha	IMP	ZFIN:ZDB-MRPHLNO-100405-1	Zfish	PMID:29601828
Biological Process	GO:0003382	epithelial cell morphogenesis	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:18582859
Biological Process	GO:0090136	epithelial cell-cell adhesion	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:18582859
Biological Process	GO:0060323	head morphogenesis	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:16935278
Biological Process	GO:0001947	heart looping	Ihh	IMP		Mouse	MGI:MGI:5142377|PMID:11517919
Biological Process	GO:0001701	in utero embryonic development	Ihh	IMP		Mouse	PMID:17881493
Biological Process	GO:0001957	intramembranous ossification	ihha	IMP	ZFIN:ZDB-GENO-100325-1	Zfish	PMID:22627283
Biological Process	GO:0097421	liver regeneration	Ihh	IEP		Rat	PMID:22024090|RGD:12911223
Biological Process	GO:0060135	maternal process involved in female pregnancy	Ihh	IEP		Rat	PMID:18612197|RGD:2306316
Biological Process	GO:0001763	morphogenesis of a branching structure	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:11044404
Biological Process	GO:0035264	multicellular organism growth	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:10821773
Biological Process	GO:0046639	negative regulation of alpha-beta T cell differentiation	Ihh	IMP		Mouse	MGI:MGI:3836494|PMID:19109233
Biological Process	GO:0043066	negative regulation of apoptotic process	Ihh	IMP		Rat	PMID:16488438|RGD:1600038
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:16284117
Biological Process	GO:0048074	negative regulation of eye pigmentation	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:17464332
Biological Process	GO:0033088	negative regulation of immature T cell proliferation in thymus	Ihh	IMP		Mouse	MGI:MGI:3836494|PMID:19109233
Biological Process	GO:0033085	negative regulation of T cell differentiation in thymus	Ihh	IMP		Mouse	MGI:MGI:3836494|PMID:19109233
Biological Process	GO:0048666	neuron development	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:10821773
Biological Process	GO:0048709	oligodendrocyte differentiation	ihhb	IMP	ZFIN:ZDB-MRPHLNO-041129-3	Zfish	PMID:23345245
Biological Process	GO:0001503	ossification	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:11748145
Biological Process	GO:0001649	osteoblast differentiation	Ihh	IGI	MGI:MGI:1928765	Mouse	PMID:25639508
Biological Process	GO:0001649	osteoblast differentiation	Ihh	IDA		Mouse	PMID:25639508
Biological Process	GO:0001649	osteoblast differentiation	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:14973297
Biological Process	GO:0001649	osteoblast differentiation	Ihh	IMP		Mouse	PMID:25639508
Biological Process	GO:0001649	osteoblast differentiation	ihha	IMP	ZFIN:ZDB-GENO-100325-1	Zfish	PMID:19906866
Biological Process	GO:0031016	pancreas development	Ihh	IGI	MGI:MGI:98297	Mouse	PMID:11044404
Biological Process	GO:0031016	pancreas development	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:10821773
Biological Process	GO:0007389	pattern specification process	Ihh	IMP	MGI:MGI:1857644	Mouse	PMID:9671585
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	Ihh	IMP		Mouse	MGI:MGI:3836494|PMID:19109233
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:16284117
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:17191253
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ihh	IGI	MGI:MGI:95729	Mouse	PMID:17191253
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:18582859
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	Ihh	IDA		Mouse	PMID:10208865
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Ihh	IMP		Rat	PMID:16488438|RGD:1600038
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:18582859
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	IHH	IDA		Human	PMID:24342078
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	Ihh	IMP		Mouse	MGI:MGI:5142377|PMID:11517919
Biological Process	GO:0033089	positive regulation of T cell differentiation in thymus	Ihh	IMP		Mouse	MGI:MGI:3836494|PMID:19109233
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ihh	IGI	MGI:MGI:98297	Mouse	PMID:17881493
Biological Process	GO:0006029	proteoglycan metabolic process	Ihh	IGI	MGI:MGI:88177	Mouse	PMID:16935278
Biological Process	GO:0040008	regulation of growth	Ihh	IGI	MGI:MGI:104903	Mouse	PMID:19590577
Biological Process	GO:0070445	regulation of oligodendrocyte progenitor proliferation	ihhb	IMP	ZFIN:ZDB-MRPHLNO-041129-3	Zfish	PMID:23345245
Biological Process	GO:0032355	response to estradiol	Ihh	IEP		Rat	PMID:17109907|RGD:1601055
Biological Process	GO:0009612	response to mechanical stimulus	Ihh	IEP		Rat	PMID:15111639|RGD:12911206
Biological Process	GO:0003406	retinal pigment epithelium development	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:18582859
Biological Process	GO:0001501	skeletal system development	IHH	IMP		Human	PMID:21537345
Biological Process	GO:0001501	skeletal system development	Ihh	IMP	MGI:MGI:2176264,MGI:MGI:3609381	Mouse	PMID:16278811
Biological Process	GO:0048745	smooth muscle tissue development	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:10821773
Biological Process	GO:0007224	smoothened signaling pathway	IHH	IDA		Human	PMID:21537345
Biological Process	GO:0007224	smoothened signaling pathway	Ihh	IDA		Mouse	PMID:25639508
Biological Process	GO:0007224	smoothened signaling pathway	Ihh	IGI	MGI:MGI:104903	Mouse	PMID:19590577
Biological Process	GO:0007224	smoothened signaling pathway	ihha	IMP	ZFIN:ZDB-GENO-100325-1	Zfish	PMID:22627283
Biological Process	GO:0061053	somite development	Ihh	IMP		Mouse	MGI:MGI:5142377|PMID:11517919
Biological Process	GO:0055002	striated muscle cell development	ihhb	IGI	ZFIN:ZDB-GENO-980202-1526	Zfish	PMID:11428131
Biological Process	GO:0048794	swim bladder development	ihha	IMP	ZFIN:ZDB-MRPHLNO-100405-1	Zfish	PMID:22008465
Biological Process	GO:0048794	swim bladder development	ihha	IMP		Zfish	PMID:21925490
Biological Process	GO:0048795	swim bladder morphogenesis	ihha	IMP	ZFIN:ZDB-MRPHLNO-100405-1	Zfish	PMID:19422819
Biological Process	GO:0001944	vasculature development	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:17881493
Biological Process	GO:0030704	vitelline membrane formation	Ihh	IMP	MGI:MGI:1934258	Mouse	PMID:17881493

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern