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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ikbkb

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ikbkb
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0005524ATP bindingIkbkbIDARatPMID:12133632|RGD:1626124
Molecular FunctionGO:0042802identical protein bindingIKBKBIPIUniProtKB:O14920HumanPMID:16319058
Molecular FunctionGO:0042802identical protein bindingIKBKBIPIUniProtKB:O14920HumanPMID:21423167
Molecular FunctionGO:0042802identical protein bindingIKBKBIPIUniProtKB:O14920HumanPMID:23776406
Molecular FunctionGO:0008384IkappaB kinase activityIkbkbIDAMousePMID:18981174
Molecular FunctionGO:0008384IkappaB kinase activityIkbkbIDARatPMID:12592100|RGD:13801014
Molecular FunctionGO:0016301kinase activityikbkbIDAZfishPMID:28808254
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q04206HumanPMID:10521409
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q99558HumanPMID:10733566
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P19838HumanPMID:11297557
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O15111HumanPMID:11971985
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6Q9HumanPMID:11971985
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P19838HumanPMID:12482991
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O15111HumanPMID:12486103
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P25963HumanPMID:12486103
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q04206HumanPMID:12842894
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O15111HumanPMID:14743216
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P25963HumanPMID:14743216
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q16543HumanPMID:14743216
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q99558HumanPMID:14743216
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:14743216
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O43524HumanPMID:15084260
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q70UQ0HumanPMID:15389287
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q96EY1-1HumanPMID:15601829
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q96EY1-2HumanPMID:15601829
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:15749833
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P03409HumanPMID:16126728
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P25963HumanPMID:16126728
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P67775HumanPMID:16126728
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:16126728
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O15111HumanPMID:16129692
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P03409HumanPMID:16129692
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P67775HumanPMID:16129692
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:16129692
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O15111HumanPMID:16286467
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P25963HumanPMID:16286467
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O15111HumanPMID:16319058
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P25963HumanPMID:16319058
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:16319058
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P25963HumanPMID:16365431
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9UGK3HumanPMID:16365431
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:16938294
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O43318HumanPMID:17363973
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:17568778
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q92574HumanPMID:17693255
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O14965HumanPMID:17939994
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P03230HumanPMID:18198944
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P24772HumanPMID:18266467
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:18266467
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:18462684
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O75688HumanPMID:18930133
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P35813HumanPMID:18930133
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P04637HumanPMID:19196987
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P25963HumanPMID:19196987
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P25963HumanPMID:19345327
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:19365808
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:19666608
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P19474HumanPMID:19675099
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:19706536
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P04637HumanPMID:19883646
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:20098747
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:20211142
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:20368414
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O15111HumanPMID:20434986
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q86WI3HumanPMID:20434986
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:20434986
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q14145HumanPMID:20600852
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P23396HumanPMID:21399639
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P25963HumanPMID:21399639
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P25963HumanPMID:21423167
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:21423167
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q6P9F5HumanPMID:21474709
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P25963HumanPMID:21765415
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O15111HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q16543HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P25963HumanPMID:22037600
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q5D1E7HumanPMID:22037600
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P24772HumanPMID:22810585
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9UKE5HumanPMID:22904686
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q14587-2HumanPMID:23091055
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:23104095
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:24618592
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q16543HumanPMID:25036637
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O15111HumanPMID:25241761
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P19838HumanPMID:25241761
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q04206HumanPMID:25241761
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q13568HumanPMID:25326418
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P25963HumanPMID:25759022
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O15111HumanPMID:25852190
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:25852190
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q96PG8HumanPMID:26212789
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q13325HumanPMID:26334375
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q16543HumanPMID:26496610
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:26496610
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q15048HumanPMID:27426725
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O15111HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q99558HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:30561431
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q99558HumanPMID:30833792
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O15111HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q99558HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O15111,UniProtKB:Q9Y6K9HumanPMID:32935379
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O43318HumanPMID:33895773
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P0DTC9HumanPMID:33895773
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:P25963HumanPMID:9520446
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q99558HumanPMID:9520446
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:O15111HumanPMID:9751060
Molecular FunctionGO:0005515protein bindingIKBKBIPIUniProtKB:Q9Y6K9HumanPMID:9751060
Molecular FunctionGO:0005515protein bindingIkbkbIPIUniProtKB:Q60680MouseMGI:MGI:3619210|PMID:16498412
Molecular FunctionGO:0005515protein bindingIkbkbIPIUniProtKB:P56477MouseMGI:MGI:5609199|PMID:25326420
Molecular FunctionGO:0005515protein bindingIkbkbIPIUniProtKB:O88522MouseMGI:MGI:5553034|PMID:24270572
Molecular FunctionGO:0005515protein bindingIkbkbIPIUniProtKB:P68040MouseMGI:MGI:3688344|PMID:15102471
Molecular FunctionGO:0005515protein bindingIkbkbIPIUniProtKB:O88522MouseMGI:MGI:4839450|PMID:16306937
Molecular FunctionGO:0005515protein bindingIkbkbIPIUniProtKB:P01375MouseMGI:MGI:5706670|PMID:26649818
Molecular FunctionGO:0005515protein bindingIkbkbIPIUniProtKB:Q14145MouseMGI:MGI:5437429|PMID:20600852
Molecular FunctionGO:0005515protein bindingIkbkbIPIUniProtKB:O88522MouseMGI:MGI:4454238|PMID:20404153
Molecular FunctionGO:0005515protein bindingIkbkbIPIUniProtKB:Q60680MouseMGI:MGI:4454346|PMID:20434986
Molecular FunctionGO:0005515protein bindingIkbkbIPIUniProtKB:O88522MouseMGI:MGI:6092615|PMID:18216269
Molecular FunctionGO:0005515protein bindingIkbkbIPIUniProtKB:O88522MouseMGI:MGI:5315695|PMID:18266467
Molecular FunctionGO:0005515protein bindingIkbkbIPIUniProtKB:O88522MouseMGI:MGI:4455093|PMID:20211142
Molecular FunctionGO:0005515protein bindingIkbkbIPIUniProtKB:Q91VL8MouseMGI:MGI:4821187|PMID:20622870
Molecular FunctionGO:0005515protein bindingIkbkbIPIPR:Q60680MousePMID:17041603
Molecular FunctionGO:0005515protein bindingIkbkbIPIPR:Q8BMS9MousePMID:22227519
Molecular FunctionGO:0005515protein bindingIkbkbIPIRGD:1309461RatPMID:15951441|RGD:10045953
Molecular FunctionGO:0005515protein bindingIkbkbIPIUniProtKB:O70377RatPMID:18692471|RGD:8553272
Molecular FunctionGO:0046982protein heterodimerization activityIKBKBIDAHumanPMID:23091055
Molecular FunctionGO:0042803protein homodimerization activityIKBKBIDAHumanPMID:23091055
Molecular FunctionGO:0004672protein kinase activityIKBKBIDAHumanPMID:20434986
Molecular FunctionGO:0004672protein kinase activityIkbkbIDAMousePMID:15684432
Molecular FunctionGO:0004672protein kinase activityIkbkbIMPMGI:MGI:2678815MousePMID:12235208
Molecular FunctionGO:0019901protein kinase bindingIKBKBIPIUniProtKB:O43283HumanPMID:12492477
Molecular FunctionGO:0019903protein phosphatase bindingIkbkbIPIUniProtKB:P35235MouseMGI:MGI:3760575|PMID:17954568
Molecular FunctionGO:0004674protein serine/threonine kinase activityIKBKBIDAHumanPMID:15084260
Molecular FunctionGO:0004674protein serine/threonine kinase activityIKBKBEXPHumanPMID:18692471
Molecular FunctionGO:0004674protein serine/threonine kinase activityIKBKBEXPHumanPMID:23613522
Molecular FunctionGO:0004674protein serine/threonine kinase activityIKBKBIDAHumanPMID:25326418
Molecular FunctionGO:0004674protein serine/threonine kinase activityIKBKBIDAHumanPMID:25636800
Molecular FunctionGO:0004674protein serine/threonine kinase activityIkbkbIDAMouseMGI:MGI:5609199|PMID:25326420
Molecular FunctionGO:0044877protein-containing complex bindingIkbkbIPIRGD:735223RatPMID:17419723|RGD:2298661
Molecular FunctionGO:0097110scaffold protein bindingIKBKBIDAHumanPMID:23776175
Molecular FunctionGO:1990459transferrin receptor bindingIKBKBIPIUniProtKB:P02786HumanPMID:23016877
Cellular ComponentGO:0035631CD40 receptor complexIkbkbIDAMouseMGI:MGI:4462284|PMID:20614026
Cellular ComponentGO:0005737cytoplasmIKBKBIDAHumanPMID:9804806
Cellular ComponentGO:0009898cytoplasmic side of plasma membraneIkbkbIDAMouseMGI:MGI:4462284|PMID:20614026
Cellular ComponentGO:0005829cytosolIKBKBIDAHumanGO_REF:0000052
Cellular ComponentGO:0005829cytosolIkbkbIDARatPMID:15147892|RGD:1626123
Cellular ComponentGO:0008385IkappaB kinase complexIkbkbIDARatPMID:17419723|RGD:2298661
Cellular ComponentGO:0043231intracellular membrane-bounded organelleIkbkbIDARatPMID:12361703|RGD:2298666
Biological ProcessGO:0001782B cell homeostasisIkbkbIMPMGI:MGI:2678815MousePMID:12235208
Biological ProcessGO:0071356cellular response to tumor necrosis factorIKBKBIDAHumanPMID:23091055
Biological ProcessGO:0030866cortical actin cytoskeleton organizationIKBKBIMPHumanPMID:25816133
Biological ProcessGO:0007249I-kappaB kinase/NF-kappaB signalingIKBKBIMPHumanPMID:15383541
Biological ProcessGO:0007249I-kappaB kinase/NF-kappaB signalingIKBKBIMPHumanPMID:25816133
Biological ProcessGO:0070498interleukin-1-mediated signaling pathwayIKBKBIMPHumanPMID:25816133
Biological ProcessGO:1903347negative regulation of bicellular tight junction assemblyIKBKBIMPHumanPMID:25816133
Biological ProcessGO:0035509negative regulation of myosin-light-chain-phosphatase activityIKBKBIMPHumanPMID:25816133
Biological ProcessGO:0031175neuron projection developmentIkbkbIMPRatPMID:21618530|RGD:7495774
Biological ProcessGO:0018105peptidyl-serine phosphorylationIKBKBIDAHumanPMID:21399639
Biological ProcessGO:0018105peptidyl-serine phosphorylationIKBKBIDAHumanPMID:25326418
Biological ProcessGO:0018105peptidyl-serine phosphorylationIkbkbIDAMouseMGI:MGI:5609199|PMID:25326420
Biological ProcessGO:2001259positive regulation of cation channel activityIkbkbIGIMGI:MGI:1933754MousePMID:18981174
Biological ProcessGO:0008284positive regulation of cell population proliferationIkbkbIMPRatPMID:15939736|RGD:7495757
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIKBKBIMPHumanPMID:30337470
Biological ProcessGO:1901216positive regulation of neuron deathIkbkbIMPRatPMID:20190013|RGD:7495771
Biological ProcessGO:0010976positive regulation of neuron projection developmentIkbkbIMPRatPMID:15935065|RGD:10045959
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityIKBKBIDAHumanPMID:15790681
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityIkbkbIMPRatPMID:15939736|RGD:7495757
Biological ProcessGO:0010765positive regulation of sodium ion transportIkbkbIGIMGI:MGI:1933754MousePMID:18981174
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIIKBKBIDAHumanPMID:23091055
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIIKBKBIDAHumanPMID:23453807
Biological ProcessGO:0072659protein localization to plasma membraneIKBKBIMPHumanPMID:25816133
Biological ProcessGO:0006468protein phosphorylationIKBKBIDAHumanPMID:15084260
Biological ProcessGO:0006468protein phosphorylationIKBKBIDAHumanPMID:20434986
Biological ProcessGO:0006468protein phosphorylationIkbkbIDAMouseMGI:MGI:6305600|PMID:30988283
Biological ProcessGO:0032465regulation of cytokinesisikbkbIMPZFIN:ZDB-GENO-180719-6ZfishPMID:28808254
Biological ProcessGO:1903140regulation of establishment of endothelial barrierIKBKBIMPHumanPMID:25816133
Biological ProcessGO:0042325regulation of phosphorylationIKBKBIDAHumanPMID:26212789
Biological ProcessGO:0061847response to cholecystokininIkbkbIDARatPMID:12592100|RGD:13801014
Biological ProcessGO:0070542response to fatty acidIkbkbIEPRatPMID:19179648|RGD:7495775
Biological ProcessGO:0032496response to lipopolysaccharideIkbkbIEPRatPMID:17594812|RGD:10045960
Biological ProcessGO:0009636response to toxic substanceIkbkbIEPRatPMID:12361703|RGD:2298666
Biological ProcessGO:0009410response to xenobiotic stimulusIkbkbIEPRatPMID:16331110|RGD:2298662
Biological ProcessGO:0003009skeletal muscle contractionIkbkbIEPRatPMID:15888549|RGD:2298664
Biological ProcessGO:0043588skin developmentikbkbIMPZFIN:ZDB-GENO-180719-4ZfishPMID:28808254
Biological ProcessGO:0033209tumor necrosis factor-mediated signaling pathwayIKBKBIMPHumanPMID:15084260
Biological ProcessGO:0033209tumor necrosis factor-mediated signaling pathwayIKBKBIMPHumanPMID:25816133
Biological ProcessGO:0033209tumor necrosis factor-mediated signaling pathwayIkbkbIMPMouseMGI:MGI:5693235|PMID:15084260

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory