Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL10
  • Mouse genes Il10
  • Rat genes Il10
  • Zfish genes il10
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il10

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	Il10	IMP	MGI:MGI:1857199	Mouse	PMID:15240714
Molecular Function	GO:0005125	cytokine activity	Il10	IDA		Mouse	PMID:11027433
Molecular Function	GO:0005141	interleukin-10 receptor binding	Il10	IDA		Rat	PMID:12405978|RGD:729323
Molecular Function	GO:0005141	interleukin-10 receptor binding	Il10	IMP		Rat	PMID:19428551|RGD:2311043
Molecular Function	GO:0005515	protein binding	IL10	IPI	UniProtKB:Q13651	Human	PMID:11485736
Molecular Function	GO:0005515	protein binding	IL10	IPI	UniProtKB:Q08334	Human	PMID:12513909
Molecular Function	GO:0005515	protein binding	IL10	IPI	UniProtKB:Q13651	Human	PMID:12513909
Molecular Function	GO:0005515	protein binding	IL10	IPI	UniProtKB:Q13651	Human	PMID:15837194
Molecular Function	GO:0005515	protein binding	IL10	IPI	UniProtKB:Q13651	Human	PMID:16982608
Molecular Function	GO:0005515	protein binding	IL10	IPI	UniProtKB:Q08334	Human	PMID:20462497
Molecular Function	GO:0005515	protein binding	IL10	IPI	UniProtKB:Q13651	Human	PMID:20462497
Molecular Function	GO:0005515	protein binding	IL10	IPI	UniProtKB:O76003	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL10	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL10	IPI	UniProtKB:P25490	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL10	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL10	IPI	UniProtKB:Q8IUG1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL10	IPI	UniProtKB:Q9BYQ7	Human	PMID:32296183
Molecular Function	GO:0046983	protein dimerization activity	IL10	IDA		Human	PMID:16982608
Cellular Component	GO:0005615	extracellular space	IL10	IDA		Human	PMID:10443688
Cellular Component	GO:0005615	extracellular space	IL10	IDA		Human	PMID:21323571
Cellular Component	GO:0005615	extracellular space	Il10	IDA		Mouse	PMID:17137799
Cellular Component	GO:0005615	extracellular space	Il10	IDA		Mouse	PMID:15220916
Cellular Component	GO:0005615	extracellular space	Il10	IDA		Mouse	PMID:10545106
Cellular Component	GO:0005615	extracellular space	Il10	IDA		Mouse	PMID:16275384
Cellular Component	GO:0005615	extracellular space	Il10	IDA		Mouse	PMID:16949315
Cellular Component	GO:0005615	extracellular space	Il10	IDA		Mouse	PMID:10899905
Cellular Component	GO:0005615	extracellular space	Il10	IDA		Mouse	PMID:10940872
Cellular Component	GO:0005615	extracellular space	Il10	IDA		Mouse	PMID:23892723
Cellular Component	GO:0005615	extracellular space	Il10	IDA		Mouse	PMID:15240714
Cellular Component	GO:0005615	extracellular space	Il10	IDA		Mouse	PMID:19139201
Cellular Component	GO:0005615	extracellular space	Il10	IDA		Rat	PMID:18787467|RGD:2308945
Biological Process	GO:0007568	aging	Il10	IEP		Rat	PMID:23873152|RGD:7364992
Biological Process	GO:0060670	branching involved in labyrinthine layer morphogenesis	Il10	IMP	MGI:MGI:1857199	Mouse	PMID:12842419
Biological Process	GO:0071392	cellular response to estradiol stimulus	Il10	IEP		Rat	PMID:20735828|RGD:4140456
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	Il10	IDA		Mouse	PMID:21072211
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IL10	IDA		Human	PMID:23071313
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Il10	IDA		Mouse	PMID:21609717
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Il10	IDA		Mouse	PMID:19047410
Biological Process	GO:0002439	chronic inflammatory response to antigenic stimulus	Il10	IMP	MGI:MGI:1857199	Mouse	PMID:12452830
Biological Process	GO:0042742	defense response to bacterium	Il10	IDA		Mouse	PMID:10899905
Biological Process	GO:0042742	defense response to bacterium	il10	IDA		Zfish	PMID:29572872
Biological Process	GO:0042742	defense response to bacterium	il10	IMP	ZFIN:ZDB-GENO-190314-17	Zfish	PMID:29985419
Biological Process	GO:0042832	defense response to protozoan	Il10	IDA		Mouse	PMID:19047410
Biological Process	GO:0006955	immune response	Il10	IMP		Rat	PMID:8484757|RGD:729048
Biological Process	GO:0006955	immune response	il10	IDA		Zfish	PMID:29572872
Biological Process	GO:0097421	liver regeneration	Il10	IEP		Rat	PMID:11813605|RGD:11049526
Biological Process	GO:0043066	negative regulation of apoptotic process	Il10	IMP		Rat	PMID:19395591|RGD:2306926
Biological Process	GO:0010507	negative regulation of autophagy	IL10	IDA		Human	PMID:26962683
Biological Process	GO:0030889	negative regulation of B cell proliferation	IL10	IDA		Human	PMID:9184696
Biological Process	GO:0008285	negative regulation of cell population proliferation	Il10	IMP		Mouse	MGI:MGI:5796069|PMID:26808574
Biological Process	GO:0002875	negative regulation of chronic inflammatory response to antigenic stimulus	Il10	IMP	MGI:MGI:1857199	Mouse	PMID:12452830
Biological Process	GO:0060302	negative regulation of cytokine activity	IL10	IMP		Human	PMID:9847016
Biological Process	GO:0001818	negative regulation of cytokine production	IL10	IDA		Human	PMID:1940799
Biological Process	GO:0001818	negative regulation of cytokine production	Il10	IMP		Rat	PMID:8484757|RGD:729048
Biological Process	GO:0002719	negative regulation of cytokine production involved in immune response	IL10	IDA		Human	PMID:10443688
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	Il10	IGI	UniProtKB:P06804	Mouse	MGI:MGI:5796069|PMID:26808574
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	Il10	IGI	UniProtKB:P06804	Mouse	MGI:MGI:5796069|PMID:26808574
Biological Process	GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	Il10	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:5291547|PMID:21857966
Biological Process	GO:0050728	negative regulation of inflammatory response	IL10	IDA		Human	PMID:10443688
Biological Process	GO:0050728	negative regulation of inflammatory response	Il10	IMP		Mouse	PMID:18270204
Biological Process	GO:0050728	negative regulation of inflammatory response	Il10	IDA		Rat	PMID:17017555|RGD:1598631
Biological Process	GO:0050728	negative regulation of inflammatory response	il10	IMP	ZFIN:ZDB-GENO-190314-17	Zfish	PMID:32641385
Biological Process	GO:0032695	negative regulation of interleukin-12 production	Il10	IMP	MGI:MGI:1857199	Mouse	PMID:15240714
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IL10	IDA		Human	PMID:10443688
Biological Process	GO:0051045	negative regulation of membrane protein ectodomain proteolysis	IL10	IDA		Human	PMID:18383040
Biological Process	GO:0045347	negative regulation of MHC class II biosynthetic process	IL10	IDA		Human	PMID:1940799
Biological Process	GO:0030886	negative regulation of myeloid dendritic cell activation	Il10	IMP	MGI:MGI:1857199	Mouse	PMID:15240714
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Il10	IDA		Rat	PMID:28753520|RGD:14975275
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	Il10	IDA		Rat	PMID:17017555|RGD:1598631
Biological Process	GO:1904057	negative regulation of sensory perception of pain	Il10	IDA		Rat	PMID:25078297|RGD:11049468
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Il10	IMP	MGI:MGI:1857199	Mouse	PMID:12452830
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Il10	IDA		Rat	PMID:17017555|RGD:1598631
Biological Process	GO:0032689	negative regulation of type II interferon production	Il10	IMP	MGI:MGI:1857199	Mouse	PMID:12452830
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	Il10	IGI	UniProtKB:P06804	Mouse	MGI:MGI:5796069|PMID:26808574
Biological Process	GO:0002904	positive regulation of B cell apoptotic process	IL10	IDA		Human	PMID:9184696
Biological Process	GO:0045787	positive regulation of cell cycle	Il10	IGI	UniProtKB:P06804	Mouse	MGI:MGI:5796069|PMID:26808574
Biological Process	GO:0001819	positive regulation of cytokine production	IL10	IDA		Human	PMID:10443688
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IL10	IDA		Human	PMID:7749983
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IL10	IDA		Human	PMID:16606666
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IL10	IMP		Human	PMID:17875732
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IL10	IDA		Human	PMID:7749983
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	Il10	IGI	UniProtKB:P06804	Mouse	MGI:MGI:5796069|PMID:26808574
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IL10	IGI	UniProtKB:P60568	Human	PMID:22962438
Biological Process	GO:0043032	positive regulation of macrophage activation	Il10	IDA		Rat	PMID:25837415|RGD:11049473
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	Il10	IDA		Mouse	PMID:11027433
Biological Process	GO:1902895	positive regulation of miRNA transcription	IL10	IDA		Human	PMID:23071313
Biological Process	GO:1900100	positive regulation of plasma cell differentiation	IL10	IGI	UniProtKB:P60568	Human	PMID:22962438
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IL10	IDA		Human	PMID:16982608
Biological Process	GO:2000273	positive regulation of signaling receptor activity	IL10	IDA		Human	PMID:10443688
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	Il10	IMP		Mouse	MGI:MGI:5749333|PMID:26235810
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il10	IDA		Mouse	MGI:MGI:3044839|PMID:15187136
Biological Process	GO:0010468	regulation of gene expression	IL10	IDA		Human	PMID:9184696
Biological Process	GO:1903034	regulation of response to wounding	Il10	IMP		Mouse	MGI:MGI:5796069|PMID:26808574
Biological Process	GO:0051930	regulation of sensory perception of pain	Il10	IDA		Rat	PMID:16949747|RGD:1598632
Biological Process	GO:0050807	regulation of synapse organization	Il10	IDA		Rat	PMID:24278397|RGD:11049480
Biological Process	GO:0014823	response to activity	Il10	IEP		Rat	PMID:19424714|RGD:2311044
Biological Process	GO:0034465	response to carbon monoxide	Il10	IEP		Rat	PMID:20622590|RGD:4140398
Biological Process	GO:0051384	response to glucocorticoid	IL10	IDA		Human	PMID:10443688
Biological Process	GO:0051384	response to glucocorticoid	Il10	IEP		Rat	PMID:16827395|RGD:1598633
Biological Process	GO:0014854	response to inactivity	Il10	IEP		Rat	PMID:17033197|RGD:1598630
Biological Process	GO:0032868	response to insulin	Il10	IEP		Rat	PMID:18791499|RGD:2308944
Biological Process	GO:0032496	response to lipopolysaccharide	Il10	IEP		Rat	PMID:18791499|RGD:2308944
Biological Process	GO:0032496	response to lipopolysaccharide	Il10	IEP		Rat	PMID:19390478|RGD:5135010
Biological Process	GO:0032496	response to lipopolysaccharide	il10	IDA		Zfish	PMID:16202237
Biological Process	GO:0002237	response to molecule of bacterial origin	IL10	IDA		Human	PMID:17449476
Biological Process	GO:0010033	response to organic substance	Il10	IEP		Rat	PMID:20360627|RGD:4140418
Biological Process	GO:0009410	response to xenobiotic stimulus	Il10	IEP		Rat	PMID:19419978|RGD:2311046
Biological Process	GO:0009410	response to xenobiotic stimulus	Il10	IEP		Rat	PMID:19422380|RGD:2311045

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern