Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL11
  • Mouse genes Il11
  • Rat genes Il11
  • Zfish genes il11a,il11b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il11

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	IL11	IDA		Human	PMID:33397952
Molecular Function	GO:0005125	cytokine activity	Il11	IDA		Mouse	PMID:7957045
Molecular Function	GO:0008083	growth factor activity	IL11	IDA		Human	PMID:2145578
Molecular Function	GO:0005142	interleukin-11 receptor binding	Il11	IPI	PR:Q64385	Mouse	PMID:7957045
Molecular Function	GO:0005515	protein binding	IL11	IPI	UniProtKB:P43364	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	IL11	IPI	UniProtKB:P43364-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	IL11	IPI	UniProtKB:P25815	Human	PMID:26551460
Molecular Function	GO:0005515	protein binding	IL11	IPI	UniProtKB:P43364	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IL11	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Cellular Component	GO:0005737	cytoplasm	Il11	IDA		Mouse	PMID:11737071
Cellular Component	GO:0005615	extracellular space	IL11	IDA		Human	PMID:33397952
Biological Process	GO:0008283	cell population proliferation	Il11	IDA		Mouse	PMID:7957045
Biological Process	GO:0042742	defense response to bacterium	il11a	IDA		Zfish	PMID:29572872
Biological Process	GO:0006955	immune response	il11a	IDA		Zfish	PMID:29572872
Biological Process	GO:0038154	interleukin-11-mediated signaling pathway	IL11	IDA		Human	PMID:33397952
Biological Process	GO:0046888	negative regulation of hormone secretion	IL11	IDA		Human	PMID:7867561
Biological Process	GO:0008284	positive regulation of cell population proliferation	IL11	IDA		Human	PMID:2145578
Biological Process	GO:0008284	positive regulation of cell population proliferation	Il11	IDA		Mouse	PMID:7957045
Biological Process	GO:0043410	positive regulation of MAPK cascade	IL11	IDA		Human	PMID:7508917
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IL11	IDA		Human	PMID:7508917
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IL11	IDA		Human	PMID:7508917
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IL11	IDA		Human	PMID:7508917

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern