Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL12A
  • Mouse genes Il12a
  • Rat genes Il12a
  • Zfish genes il12a,zmp:0000001127
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il12a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	IL12A	IDA		Human	PMID:1674604
Molecular Function	GO:0005125	cytokine activity	IL12A	IDA		Human	PMID:7584494
Molecular Function	GO:0005125	cytokine activity	Il12a	IDA		Mouse	PMID:11057672
Molecular Function	GO:0008083	growth factor activity	IL12A	IDA		Human	PMID:1674604
Molecular Function	GO:0042163	interleukin-12 beta subunit binding	IL12A	IPI	UniProtKB:P29460	Human	PMID:11023671
Molecular Function	GO:0042163	interleukin-12 beta subunit binding	IL12A	IPI	UniProtKB:P68220	Human	PMID:11023671
Molecular Function	GO:0042163	interleukin-12 beta subunit binding	Il12a	IPI	PR:P43432	Mouse	PMID:15220916
Molecular Function	GO:0045513	interleukin-27 binding	IL12A	IPI	UniProtKB:Q14213	Human	PMID:9342359
Molecular Function	GO:0005515	protein binding	IL12A	IDA		Human	PMID:10899108
Molecular Function	GO:0005515	protein binding	IL12A	IPI	UniProtKB:P29460	Human	PMID:10899108
Molecular Function	GO:0005515	protein binding	IL12A	IPI	UniProtKB:W5PUF3	Human	PMID:11023671
Molecular Function	GO:0005515	protein binding	IL12A	IPI	UniProtKB:P29460	Human	PMID:7527811
Molecular Function	GO:0005515	protein binding	Il12a	IPI	UniProtKB:O35228	Mouse	MGI:MGI:4867804|PMID:20953201
Molecular Function	GO:0005515	protein binding	Il12a	IPI	UniProtKB:O35228	Mouse	MGI:MGI:3765091|PMID:18033300
Molecular Function	GO:0046982	protein heterodimerization activity	IL12A	IPI	UniProtKB:P29460	Human	PMID:11023671
Molecular Function	GO:0046982	protein heterodimerization activity	IL12A	IPI	UniProtKB:P68220	Human	PMID:11023671
Molecular Function	GO:0046982	protein heterodimerization activity	IL12A	IPI	UniProtKB:P29460	Human	PMID:1674604
Cellular Component	GO:0009986	cell surface	Il12a	IDA		Mouse	PMID:20818394
Cellular Component	GO:0005737	cytoplasm	Il12a	IDA		Mouse	PMID:11737071
Cellular Component	GO:0005615	extracellular space	IL12A	IDA		Human	PMID:10899108
Cellular Component	GO:0005615	extracellular space	IL12A	IDA		Human	PMID:16456693
Cellular Component	GO:0005615	extracellular space	Il12a	IDA		Mouse	PMID:7690439
Cellular Component	GO:0005615	extracellular space	Il12a	IDA		Mouse	PMID:15220916
Cellular Component	GO:0043514	interleukin-12 complex	IL12A	IDA		Human	PMID:11023671
Cellular Component	GO:0043514	interleukin-12 complex	IL12A	IDA		Human	PMID:11114383
Cellular Component	GO:0043514	interleukin-12 complex	IL12A	IDA		Human	PMID:2204066
Cellular Component	GO:0043514	interleukin-12 complex	Il12a	IDA		Mouse	PMID:15220916
Cellular Component	GO:0043514	interleukin-12 complex	Il12a	IGI	MGI:MGI:96540	Mouse	PMID:7690439
Biological Process	GO:0016477	cell migration	IL12A	IDA		Human	PMID:7903063
Biological Process	GO:0008283	cell population proliferation	Il12a	IGI	MGI:MGI:107936	Mouse	PMID:15843532
Biological Process	GO:0008283	cell population proliferation	Il12a	IDA		Mouse	PMID:15843532
Biological Process	GO:0008283	cell population proliferation	Il12a	IGI	MGI:MGI:96540	Mouse	PMID:15843532
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Il12a	IDA		Mouse	PMID:19047410
Biological Process	GO:0098586	cellular response to virus	IL12A	IMP		Human	PMID:25754930
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IL12A	IEP		Human	PMID:1357073
Biological Process	GO:0042832	defense response to protozoan	Il12a	IDA		Mouse	PMID:19050265
Biological Process	GO:0042832	defense response to protozoan	Il12a	IDA		Mouse	PMID:19047410
Biological Process	GO:0042832	defense response to protozoan	Il12a	IGI	MGI:MGI:96540	Mouse	PMID:9348310
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IL12A	IDA		Human	PMID:16942485
Biological Process	GO:0035722	interleukin-12-mediated signaling pathway	IL12A	IDA		Human	PMID:10899108
Biological Process	GO:0035722	interleukin-12-mediated signaling pathway	IL12A	IDA		Human	PMID:7584494
Biological Process	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IL12A	IGI	UniProtKB:P29460	Human	PMID:30106099
Biological Process	GO:0032700	negative regulation of interleukin-17 production	IL12A	IDA		Human	PMID:16482511
Biological Process	GO:0050709	negative regulation of protein secretion	IL12A	IGI	UniProtKB:P29460	Human	PMID:30106099
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	IL12A	IDA		Human	PMID:16942485
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	IL12A	IGI	UniProtKB:P29460	Human	PMID:30106099
Biological Process	GO:0045785	positive regulation of cell adhesion	IL12A	IDA		Human	PMID:7903063
Biological Process	GO:2000510	positive regulation of dendritic cell chemotaxis	IL12A	IMP		Human	PMID:25754930
Biological Process	GO:0050671	positive regulation of lymphocyte proliferation	IL12A	IDA		Human	PMID:1674604
Biological Process	GO:0050671	positive regulation of lymphocyte proliferation	IL12A	IDA		Human	PMID:2204066
Biological Process	GO:0032946	positive regulation of mononuclear cell proliferation	IL12A	IMP		Human	PMID:11023671
Biological Process	GO:0032816	positive regulation of natural killer cell activation	IL12A	IDA		Human	PMID:1674604
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IL12A	IDA		Human	PMID:2204066
Biological Process	GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IL12A	IDA		Human	PMID:7903063
Biological Process	GO:0051135	positive regulation of NK T cell activation	IL12A	IDA		Human	PMID:19088061
Biological Process	GO:0034393	positive regulation of smooth muscle cell apoptotic process	IL12A	IDA		Human	PMID:16942485
Biological Process	GO:0045582	positive regulation of T cell differentiation	Il12a	IGI	MGI:MGI:1916927	Mouse	PMID:22968459
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	IL12A	IDA		Human	PMID:1674604
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	IL12A	IDA		Human	PMID:2204066
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il12a	IDA		Mouse	MGI:MGI:1927676|PMID:11114383
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il12a	IDA		Mouse	PMID:11057672
Biological Process	GO:0032729	positive regulation of type II interferon production	IL12A	IDA		Human	PMID:11114383
Biological Process	GO:0032729	positive regulation of type II interferon production	IL12A	IDA		Human	PMID:1674604
Biological Process	GO:0032729	positive regulation of type II interferon production	IL12A	IDA		Human	PMID:19088061
Biological Process	GO:0032729	positive regulation of type II interferon production	Il12a	IGI	MGI:MGI:96540	Mouse	PMID:9348310
Biological Process	GO:0032729	positive regulation of type II interferon production	Il12a	IGI	MGI:MGI:96540	Mouse	PMID:15843532
Biological Process	GO:0032729	positive regulation of type II interferon production	Il12a	IGI	MGI:MGI:107936	Mouse	PMID:15843532
Biological Process	GO:0032729	positive regulation of type II interferon production	Il12a	IDA		Mouse	PMID:21444916
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IL12A	IDA		Human	PMID:12372421
Biological Process	GO:0043330	response to exogenous dsRNA	il12a	IDA		Zfish	PMID:19201835
Biological Process	GO:1990638	response to granulocyte colony-stimulating factor	Il12a	IEP		Rat	PMID:12668156|RGD:25671475
Biological Process	GO:0032496	response to lipopolysaccharide	IL12A	IDA		Human	PMID:7605994
Biological Process	GO:0032496	response to lipopolysaccharide	IL12A	IDA		Human	PMID:8557999
Biological Process	GO:0032496	response to lipopolysaccharide	il12a	IDA		Zfish	PMID:19201835
Biological Process	GO:0002237	response to molecule of bacterial origin	il12a	IDA		Zfish	PMID:19201835
Biological Process	GO:0010224	response to UV-B	IL12A	IDA		Human	PMID:8992506
Biological Process	GO:0009615	response to virus	IL12A	IEP		Human	PMID:16548883
Biological Process	GO:0042098	T cell proliferation	Il12a	IDA		Mouse	PMID:11057672
Biological Process	GO:0035711	T-helper 1 cell activation	Il12a	IDA		Mouse	PMID:22851706
Biological Process	GO:0035744	T-helper 1 cell cytokine production	Il12a	IGI	MGI:MGI:96540	Mouse	PMID:15843532
Biological Process	GO:0035744	T-helper 1 cell cytokine production	Il12a	IGI	MGI:MGI:107936	Mouse	PMID:15843532
Biological Process	GO:0032609	type II interferon production	Il12a	IGI	MGI:MGI:96540	Mouse	PMID:9348310
Biological Process	GO:0032609	type II interferon production	Il12a	IDA		Mouse	PMID:21444916

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern