Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Il12b

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes IL12B
- Mouse genes Il12b
- Rat genes Il12b
- Zfish genes il12ba,il12bb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il12b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	IL12B	IDA		Human	PMID:1674604
Molecular Function	GO:0005125	cytokine activity	IL12B	IDA		Human	PMID:7584494
Molecular Function	GO:0005125	cytokine activity	Il12b	IDA		Mouse	PMID:11057672
Molecular Function	GO:0005126	cytokine receptor binding	Il12b	IPI	UniProtKB:Q60837	Mouse	MGI:MGI:1927676\|PMID:11114383
Molecular Function	GO:0008083	growth factor activity	IL12B	IDA		Human	PMID:1674604
Molecular Function	GO:0042802	identical protein binding	IL12B	IPI	UniProtKB:P29460	Human	PMID:7527811
Molecular Function	GO:0042802	identical protein binding	Il12b	IPI	PR:P43432	Mouse	PMID:12871593
Molecular Function	GO:0042164	interleukin-12 alpha subunit binding	IL12B	IPI	UniProtKB:E7ENE1	Human	PMID:11023671
Molecular Function	GO:0042164	interleukin-12 alpha subunit binding	IL12B	IPI	UniProtKB:E9PGR3	Human	PMID:11023671
Molecular Function	GO:0042164	interleukin-12 alpha subunit binding	IL12B	IPI	UniProtKB:O60595	Human	PMID:11023671
Molecular Function	GO:0042164	interleukin-12 alpha subunit binding	IL12B	IPI	UniProtKB:P29459	Human	PMID:11023671
Molecular Function	GO:0042164	interleukin-12 alpha subunit binding	IL12B	IPI	UniProtKB:Q9TU27	Human	PMID:11023671
Molecular Function	GO:0042164	interleukin-12 alpha subunit binding	Il12b	IPI	PR:P43431	Mouse	PMID:15220916
Molecular Function	GO:0042164	interleukin-12 alpha subunit binding	Il12b	IDA		Rat	PMID:16716808\|RGD:1600058
Molecular Function	GO:0045519	interleukin-23 receptor binding	IL12B	IDA		Human	PMID:11114383
Molecular Function	GO:0005515	protein binding	IL12B	IPI	UniProtKB:P29459	Human	PMID:10899108
Molecular Function	GO:0005515	protein binding	IL12B	IPI	UniProtKB:W5NVX4	Human	PMID:11023671
Molecular Function	GO:0005515	protein binding	IL12B	IPI	UniProtKB:Q9EQ14	Human	PMID:11114383
Molecular Function	GO:0005515	protein binding	IL12B	IPI	UniProtKB:Q9NPF7	Human	PMID:11114383
Molecular Function	GO:0005515	protein binding	IL12B	IPI	UniProtKB:Q9NPF7	Human	PMID:12023369
Molecular Function	GO:0005515	protein binding	IL12B	IPI	UniProtKB:Q9NPF7	Human	PMID:18680750
Molecular Function	GO:0005515	protein binding	IL12B	IPI	UniProtKB:Q9NPF7	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	IL12B	IPI	UniProtKB:P29459	Human	PMID:7527811
Molecular Function	GO:0005515	protein binding	Il12b	IPI	UniProtKB:Q9EQ14	Mouse	MGI:MGI:1927676\|PMID:11114383
Molecular Function	GO:0046982	protein heterodimerization activity	IL12B	IPI	UniProtKB:E7ENE1	Human	PMID:11023671
Molecular Function	GO:0046982	protein heterodimerization activity	IL12B	IPI	UniProtKB:E9PGR3	Human	PMID:11023671
Molecular Function	GO:0046982	protein heterodimerization activity	IL12B	IPI	UniProtKB:O60595	Human	PMID:11023671
Molecular Function	GO:0046982	protein heterodimerization activity	IL12B	IPI	UniProtKB:P29459	Human	PMID:11023671
Molecular Function	GO:0046982	protein heterodimerization activity	IL12B	IPI	UniProtKB:Q9TU27	Human	PMID:11023671
Molecular Function	GO:0046982	protein heterodimerization activity	IL12B	IPI	UniProtKB:P29459	Human	PMID:1674604
Molecular Function	GO:0044877	protein-containing complex binding	Il12b	IDA		Rat	PMID:16716808\|RGD:1600058
Cellular Component	GO:0009986	cell surface	Il12b	IDA		Mouse	PMID:20818394
Cellular Component	GO:0005737	cytoplasm	Il12b	IDA		Mouse	PMID:11737071
Cellular Component	GO:0005615	extracellular space	IL12B	IDA		Human	PMID:7584494
Cellular Component	GO:0005615	extracellular space	Il12b	IDA		Mouse	MGI:MGI:6810691\|PMID:12417590
Cellular Component	GO:0005615	extracellular space	Il12b	IDA		Mouse	PMID:12871593
Cellular Component	GO:0005615	extracellular space	Il12b	IDA		Mouse	PMID:23892723
Cellular Component	GO:0005615	extracellular space	Il12b	IDA		Mouse	PMID:15692051
Cellular Component	GO:0005615	extracellular space	Il12b	IDA		Mouse	PMID:16236719
Cellular Component	GO:0005615	extracellular space	Il12b	IDA		Mouse	PMID:15240714
Cellular Component	GO:0005615	extracellular space	Il12b	IDA		Mouse	PMID:15220916
Cellular Component	GO:0005615	extracellular space	Il12b	IDA		Mouse	PMID:12855817
Cellular Component	GO:0005615	extracellular space	Il12b	IDA		Mouse	PMID:17277142
Cellular Component	GO:0005615	extracellular space	Il12b	IDA		Mouse	PMID:9348310
Cellular Component	GO:0005615	extracellular space	Il12b	IDA		Mouse	PMID:7690439
Cellular Component	GO:0005615	extracellular space	Il12b	IDA		Rat	PMID:10415618\|RGD:1600057
Cellular Component	GO:0043514	interleukin-12 complex	IL12B	IDA		Human	PMID:11114383
Cellular Component	GO:0043514	interleukin-12 complex	IL12B	IDA		Human	PMID:1674604
Cellular Component	GO:0043514	interleukin-12 complex	Il12b	IGI	MGI:MGI:96539	Mouse	PMID:7690439
Cellular Component	GO:0043514	interleukin-12 complex	Il12b	IDA		Mouse	PMID:15220916
Cellular Component	GO:0043514	interleukin-12 complex	Il12b	IDA		Rat	PMID:16716808\|RGD:1600058
Cellular Component	GO:0070743	interleukin-23 complex	IL12B	IDA		Human	PMID:11114383
Cellular Component	GO:0070743	interleukin-23 complex	Il12b	IDA		Mouse	MGI:MGI:1927676\|PMID:11114383
Cellular Component	GO:0070743	interleukin-23 complex	Il12b	IPI		Mouse	MGI:MGI:1927676\|PMID:11114383
Biological Process	GO:0016477	cell migration	IL12B	IDA		Human	PMID:7903063
Biological Process	GO:0008283	cell population proliferation	Il12b	IGI	MGI:MGI:107936	Mouse	PMID:15843532
Biological Process	GO:0008283	cell population proliferation	Il12b	IDA		Mouse	PMID:15843532
Biological Process	GO:0008283	cell population proliferation	Il12b	IGI	MGI:MGI:96539	Mouse	PMID:15843532
Biological Process	GO:0007166	cell surface receptor signaling pathway	Il12b	IDA		Mouse	PMID:12871593
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Il12b	IDA		Mouse	PMID:21606371
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Il12b	IDA		Mouse	PMID:18025219
Biological Process	GO:0071346	cellular response to type II interferon	Il12b	IDA		Mouse	PMID:18025219
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IL12B	IDA		Human	PMID:15114670
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IL12B	IDA		Human	PMID:20027291
Biological Process	GO:0042832	defense response to protozoan	Il12b	IGI	MGI:MGI:96539	Mouse	PMID:9348310
Biological Process	GO:0042832	defense response to protozoan	Il12b	IDA		Mouse	PMID:19050265
Biological Process	GO:0042832	defense response to protozoan	Il12b	IMP	MGI:MGI:1857201	Mouse	PMID:9348310
Biological Process	GO:0051607	defense response to virus	Il12b	IDA		Mouse	PMID:17277142
Biological Process	GO:0035722	interleukin-12-mediated signaling pathway	IL12B	IDA		Human	PMID:7584494
Biological Process	GO:0030101	natural killer cell activation	IL12B	IDA		Human	PMID:1673147
Biological Process	GO:0002323	natural killer cell activation involved in immune response	Il12b	IMP		Rat	PMID:14960310\|RGD:1600048
Biological Process	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IL12B	IGI	UniProtKB:P29459	Human	PMID:30106099
Biological Process	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	Il12b	IMP		Mouse	PMID:16949315
Biological Process	GO:0032693	negative regulation of interleukin-10 production	IL12B	IMP		Human	PMID:16751425
Biological Process	GO:0032700	negative regulation of interleukin-17 production	IL12B	IDA		Human	PMID:16482511
Biological Process	GO:0050709	negative regulation of protein secretion	IL12B	IGI	UniProtKB:P29459	Human	PMID:30106099
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	IL12B	IDA		Human	PMID:16942485
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	IL12B	IGI	UniProtKB:P29459	Human	PMID:30106099
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IL12B	IDA		Human	PMID:11114383
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IL12B	IDA		Human	PMID:1674604
Biological Process	GO:0010536	positive regulation of activation of Janus kinase activity	IL12B	IDA		Human	PMID:12023369
Biological Process	GO:0045785	positive regulation of cell adhesion	IL12B	IDA		Human	PMID:7903063
Biological Process	GO:0002230	positive regulation of defense response to virus by host	IL12B	IDA		Human	PMID:12421946
Biological Process	GO:0002230	positive regulation of defense response to virus by host	Il12b	IDA		Mouse	MGI:MGI:3027369\|PMID:14688363
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	IL12B	IDA		Human	PMID:20027291
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IL12B	IDA		Human	PMID:15265908
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IL12B	IDA		Human	PMID:20027291
Biological Process	GO:0032740	positive regulation of interleukin-17 production	IL12B	IDA		Human	PMID:16482511
Biological Process	GO:0032740	positive regulation of interleukin-17 production	IL12B	IDA		Human	PMID:16751425
Biological Process	GO:0032740	positive regulation of interleukin-17 production	IL12B	IDA		Human	PMID:17888176
Biological Process	GO:0050671	positive regulation of lymphocyte proliferation	IL12B	IDA		Human	PMID:1674604
Biological Process	GO:0032946	positive regulation of mononuclear cell proliferation	IL12B	IMP		Human	PMID:11023671
Biological Process	GO:0032816	positive regulation of natural killer cell activation	IL12B	IDA		Human	PMID:1674604
Biological Process	GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IL12B	IDA		Human	PMID:7903063
Biological Process	GO:0032819	positive regulation of natural killer cell proliferation	IL12B	IDA		Human	PMID:19088061
Biological Process	GO:0051135	positive regulation of NK T cell activation	IL12B	IDA		Human	PMID:19088061
Biological Process	GO:0051142	positive regulation of NK T cell proliferation	IL12B	IDA		Human	PMID:19088061
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IL12B	IDA		Human	PMID:17888176
Biological Process	GO:0034393	positive regulation of smooth muscle cell apoptotic process	IL12B	IDA		Human	PMID:16942485
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	Il12b	IDA		Mouse	MGI:MGI:3027369\|PMID:14688363
Biological Process	GO:0042102	positive regulation of T cell proliferation	IL12B	IDA		Human	PMID:12023369
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il12b	IDA		Mouse	MGI:MGI:1927676\|PMID:11114383
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il12b	IDA		Mouse	PMID:11057672
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	IL12B	IDA		Human	PMID:15114670
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	Il12b	IDA		Mouse	MGI:MGI:3027369\|PMID:14688363
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IL12B	IMP		Human	PMID:16751425
Biological Process	GO:0032729	positive regulation of type II interferon production	IL12B	IDA		Human	PMID:11114383
Biological Process	GO:0032729	positive regulation of type II interferon production	IL12B	IDA		Human	PMID:1674604
Biological Process	GO:0032729	positive regulation of type II interferon production	IL12B	IDA		Human	PMID:19088061
Biological Process	GO:0032729	positive regulation of type II interferon production	IL12B	IDA		Human	PMID:20027291
Biological Process	GO:0032729	positive regulation of type II interferon production	Il12b	IMP		Mouse	PMID:16949315
Biological Process	GO:0032729	positive regulation of type II interferon production	Il12b	IGI	MGI:MGI:96539	Mouse	PMID:9348310
Biological Process	GO:0032729	positive regulation of type II interferon production	Il12b	IDA		Mouse	PMID:21444916
Biological Process	GO:0032729	positive regulation of type II interferon production	Il12b	IGI	MGI:MGI:107936	Mouse	PMID:15843532
Biological Process	GO:0032729	positive regulation of type II interferon production	Il12b	IGI	MGI:MGI:96539	Mouse	PMID:15843532
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IL12B	IDA		Human	PMID:12023369
Biological Process	GO:0042509	regulation of tyrosine phosphorylation of STAT protein	IL12B	IDA		Human	PMID:12023369
Biological Process	GO:0010033	response to organic substance	Il12b	IDA		Mouse	PMID:17475835
Biological Process	GO:0010224	response to UV-B	IL12B	IDA		Human	PMID:8992506
Biological Process	GO:0019233	sensory perception of pain	Il12b	IDA		Rat	PMID:16024732\|RGD:1600053
Biological Process	GO:0042098	T cell proliferation	Il12b	IDA		Mouse	PMID:11057672
Biological Process	GO:0035744	T-helper 1 cell cytokine production	Il12b	IGI	MGI:MGI:107936	Mouse	PMID:15843532
Biological Process	GO:0035744	T-helper 1 cell cytokine production	Il12b	IGI	MGI:MGI:96539	Mouse	PMID:15843532
Biological Process	GO:0042093	T-helper cell differentiation	IL12B	IDA		Human	PMID:1673147
Biological Process	GO:0032609	type II interferon production	Il12b	IGI	MGI:MGI:96539	Mouse	PMID:9348310
Biological Process	GO:0032609	type II interferon production	Il12b	IDA		Mouse	PMID:21444916

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.