Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL15
  • Mouse genes Il15
  • Rat genes Il15
  • Zfish genes il15
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il15

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	IL15	IDA		Human	PMID:9097905
Molecular Function	GO:0005125	cytokine activity	Il15	IMP	MGI:MGI:2136897	Mouse	PMID:10704459
Molecular Function	GO:0005125	cytokine activity	Il15	IDA		Mouse	PMID:14607906
Molecular Function	GO:0005515	protein binding	IL15	IPI	UniProtKB:Q13261	Human	PMID:16284400
Molecular Function	GO:0005515	protein binding	IL15	IPI	UniProtKB:P14784	Human	PMID:23104097
Molecular Function	GO:0005515	protein binding	IL15	IPI	UniProtKB:Q13261	Human	PMID:23104097
Molecular Function	GO:0005515	protein binding	IL15	IPI	UniProtKB:P14784	Human	PMID:25416956
Cellular Component	GO:0009986	cell surface	Il15	IDA		Rat	PMID:16002563|RGD:5024917
Cellular Component	GO:0005737	cytoplasm	Il15	IDA		Mouse	PMID:11737071
Cellular Component	GO:0005829	cytosol	IL15	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005615	extracellular space	IL15	IDA		Human	PMID:9097905
Cellular Component	GO:0005615	extracellular space	Il15	IDA		Rat	PMID:17667861|RGD:5013835
Cellular Component	GO:0016607	nuclear speck	IL15	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	IL15	IDA		Human	GO_REF:0000052
Biological Process	GO:0007568	aging	Il15	IEP		Rat	PMID:17135303|RGD:1626613
Biological Process	GO:0048469	cell maturation	Il15	IGI	MGI:MGI:1931086	Mouse	PMID:17318811
Biological Process	GO:0071305	cellular response to vitamin D	Il15	IEP		Rat	PMID:15637289|RGD:2311387
Biological Process	GO:0045062	extrathymic T cell selection	Il15	IMP	MGI:MGI:2136897	Mouse	PMID:10704459
Biological Process	GO:0030212	hyaluronan metabolic process	Il15	IDA		Rat	PMID:17667861|RGD:5013835
Biological Process	GO:0006954	inflammatory response	Il15	IEP		Rat	PMID:12572774|RGD:1626616
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	IL15	IDA		Human	PMID:15123770
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	IL15	IDA		Human	PMID:24942581
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	IL15	IDA		Human	PMID:9097905
Biological Process	GO:0048535	lymph node development	Il15	IMP	MGI:MGI:2136897	Mouse	PMID:10704459
Biological Process	GO:0030225	macrophage differentiation	IL15	IDA		Human	PMID:24942581
Biological Process	GO:0001779	natural killer cell differentiation	Il15	IDA		Mouse	PMID:14607906
Biological Process	GO:0001779	natural killer cell differentiation	Il15	IMP	MGI:MGI:2136897	Mouse	PMID:14607906
Biological Process	GO:0001787	natural killer cell proliferation	Il15	IDA		Mouse	PMID:14607906
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Il15	IMP		Mouse	MGI:MGI:6103279|PMID:27684068
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	Il15	IMP		Rat	PMID:17667861|RGD:5013835
Biological Process	GO:0042119	neutrophil activation	IL15	IDA		Human	PMID:15123770
Biological Process	GO:0001866	NK T cell proliferation	Il15	IMP	MGI:MGI:2136897	Mouse	PMID:10704459
Biological Process	GO:0008284	positive regulation of cell population proliferation	Il15	IMP		Rat	PMID:9826341|RGD:1626618
Biological Process	GO:0050778	positive regulation of immune response	Il15	IMP	MGI:MGI:2136897	Mouse	PMID:10704459
Biological Process	GO:0032740	positive regulation of interleukin-17 production	IL15	IDA		Human	PMID:16482511
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	Il15	IGI	MGI:MGI:1931086	Mouse	PMID:17318811
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	Il15	IDA		Mouse	PMID:14607906
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	Il15	IMP	MGI:MGI:2136897	Mouse	PMID:14607906
Biological Process	GO:0032819	positive regulation of natural killer cell proliferation	Il15	IDA		Mouse	PMID:14607906
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IL15	IDA		Human	PMID:15123770
Biological Process	GO:0050766	positive regulation of phagocytosis	IL15	IDA		Human	PMID:15123770
Biological Process	GO:1904100	positive regulation of protein O-linked glycosylation	Il15	IMP		Mouse	PMID:24509081
Biological Process	GO:0042102	positive regulation of T cell proliferation	Il15	IMP	MGI:MGI:2136897	Mouse	PMID:10704459
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Il15	IDA		Rat	PMID:8942753|RGD:5024920
Biological Process	GO:0050691	regulation of defense response to virus by host	Il15	IMP	MGI:MGI:2136897	Mouse	PMID:10704459
Biological Process	GO:0045580	regulation of T cell differentiation	Il15	IMP	MGI:MGI:2136897	Mouse	PMID:10704459
Biological Process	GO:0031667	response to nutrient levels	Il15	IEP		Rat	PMID:19396981|RGD:5013833
Biological Process	GO:0014732	skeletal muscle atrophy	Il15	IEP		Rat	PMID:17135303|RGD:1626613
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	IL15	IDA		Human	PMID:12244150

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern