Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IL16
  • Mouse genes Il16
  • Rat genes Il16
  • Zfish genes il16
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il16

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042609	CD4 receptor binding	IL16	IPI	UniProtKB:P01730	Human	PMID:24942581
Molecular Function	GO:0005125	cytokine activity	Il16	IDA		Mouse	PMID:9637508
Molecular Function	GO:0005515	protein binding	Il16	IPI	UniProtKB:Q7TS72	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Il16	IPI	PR:P08505	Mouse	PMID:9637508
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Il16	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0005829	cytosol	IL16	IDA		Human	GO_REF:0000052
Cellular Component	GO:0090543	Flemming body	IL16	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	IL16	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005622	intracellular anatomical structure	Il16	IDA		Mouse	PMID:9598300
Cellular Component	GO:0016607	nuclear speck	IL16	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	IL16	IDA		Human	GO_REF:0000052
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Il16	IDA		Mouse	MGI:MGI:6414686|PMID:30089723
Biological Process	GO:0050930	induction of positive chemotaxis	Il16	IDA		Mouse	PMID:9637508
Biological Process	GO:0030595	leukocyte chemotaxis	Il16	IDA		Mouse	PMID:9637508
Biological Process	GO:0032722	positive regulation of chemokine production	Il16	IDA		Mouse	MGI:MGI:6414686|PMID:30089723
Biological Process	GO:0010628	positive regulation of gene expression	Il16	IDA		Mouse	MGI:MGI:6414686|PMID:30089723
Biological Process	GO:0050729	positive regulation of inflammatory response	IL16	IDA		Human	PMID:30634164
Biological Process	GO:0032730	positive regulation of interleukin-1 alpha production	IL16	IDA		Human	PMID:30634164
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IL16	IDA		Human	PMID:30634164
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IL16	IDA		Human	PMID:30634164
Biological Process	GO:1902565	positive regulation of neutrophil activation	Il16	IDA		Mouse	MGI:MGI:6414686|PMID:30089723
Biological Process	GO:0051924	regulation of calcium ion transport	IL16	IDA		Human	PMID:24942581

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern